Pathogenesis of Youth and Type 2 Diabetes and Prediabetes

Trial Purpose and Description

Type 2 Diabetes in obese youth is often preceded by a prediabetic state called: Impaired Glucose Tolerance (IGT), which is associated with a pre-existing defect in insulin secretion. We will determine here if genetic factors are associated with defects in insulin secretion and incretin system and hepatic insulin resistance in obese adolescents. Our long term goal is to generate information on both the genetics as well as the pathophysiology of Type 2 Diabetes in Youth, which ultimately might guide us towards better preventive and treatment avenues.

Ages: 12 - 18 years

Gender: Both

Eligibility Criteria

  • Inclusion
  • Both males and females are eligible between the ages of 12 and 18. They must be overweight or obese but have no other significant medical conditions (no kidney, liver or cardiac issues). Prediabetes is ok.
  • Exclusion:
  • We do not accept healthy volunteers. Participants must be overweight or obese with risk for prediabetes.

Robert Leet and Clara Guthrie Patterson Trust

Start Date: 02/22/2017

End Date: 10/01/2022

Last Updated: 06/22/2018

Study HIC#: 2000020183

Get Involved

For more information about this study, contact:
Bridget Pierpont
+1 203-785-2942

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email or call 1-877-978-8348.

Trial Image


Sonia Caprio

Principal Investigator