Trial Purpose and Description
Type 2 Diabetes in obese youth is often preceded by a prediabetic state called: Impaired Glucose Tolerance (IGT), which is associated with a pre-existing defect in insulin secretion. We will determine here if genetic factors are associated with defects in insulin secretion and incretin system and hepatic insulin resistance in obese adolescents. Our long term goal is to generate information on both the genetics as well as the pathophysiology of Type 2 Diabetes in Youth, which ultimately might guide us towards better preventive and treatment avenues.
Ages: 12 - 18 years
- Both males and females are eligible between the ages of 12 and 18. They must be overweight or obese but have no other significant medical conditions (no kidney, liver or cardiac issues). Prediabetes is ok.
- We do not accept healthy volunteers. Participants must be overweight or obese with risk for prediabetes.
Robert Leet and Clara Guthrie Patterson Trust
Start Date: 02/22/2017
End Date: 10/01/2022
Last Updated: 06/22/2018
Study HIC#: 2000020183