Trial Purpose and Description
The aim of this project is to determine the role of genetic variation in the diversity of human immune response by testing DNA polymorphisms for association with immunological phenotypes in individuals with no clinical evidence of inflammatory or infectious diseases. In the subject population of this study, immunophenotypes will be characterized from serum and from peripheral blood mononuclear cells (PBMCs). Cytometric, RNA profiling and proteomic platforms will be used in these serological and cellular analyses. This study will genetically dissect human immune gene expression in a cohort of individuals with no clinical evidence of disease, yielding a wealth of data with which to guide the investigation of inflammatory and infectious diseases.
Ages: 18 - 54 years
Healthy individuals (greater than 18 years of age and less than 55 years of age at enrollment) who are willing to donate blood up to 8 times a year for up to five years or a shorter period of time
Subjects who are unable or unwilling to donate blood samples
Individuals with self-reported chronic metabolic diseases (Diabetes Mellitus type II, hypothyroidism, pituitary abnormality), chronic infectious diseases (Hepatitis B Virus, Hepatitis C Virus, Human Immunodeficiency Virus, Human T-Lymphotrophic Virus, Tuberculosis), or immune mediated diseases (Ankylosing Spondylitis, Asthma, Diabetes Mellitus type I, Inflammatory Bowel Disease, Multiple Sclerosis, Psoriasis, Rheumatoid Arthritis, Sarcoidosis, Systemic Lupus Erythematosus, Systemic Sclerosis, Thyroiditis), current or prior history of malignancy (solid organ or leukemia/lymphoma), transplant recipients (solid organ or bone marrow) or if currently pregnant.
National Multiple Sclerosis Society
Start Date: 10/12/2010
End Date: 12/31/2025
Last Updated: 06/22/2018
Study HIC#: 1008007275REG