Yale researchers are working on a whole new type of vaccine, targeting the insects that carry pathogens
A group of Yale researchers is working on a new kind of vaccine they believe could change the world: instead of acting against a pathogen, the vaccine would reduce the risk of transmission for mosquito-and-tick-borne illnesses by targeting the insects themselves.Source: Stamford Advocate
Low mobility predicts hospital readmission in older heart attack patients
Close to 20% of elderly adults who have suffered a heart attack will be readmitted to the hospital within 30 days. Performance on a simple mobility test is the best predictor of whether an elderly heart attack patient will be readmitted, a Yale-led study reports.
Yale center dedicated to research on older adults receives renewed funding
For the fifth consecutive time, the Yale Claude D. Pepper Older Americans Independence Center (OAIC) has been renewed for funding from the National Institute on Aging (NIA). The Center is one of only two such programs nationwide to receive continuous NIA support since it was first funded in 1992, marking more than 25 years of excellence in geriatrics and aging research under the leadership of Geriatrics Section Chief Dr. Mary Tinetti, Dr. Thomas Gill, and Dr. Terri Fried.
Dr. Gerald Shulman wins American Diabetes Association’s highest honor
Dr. Gerald I. Shulman of the Yale School of Medicine has won the 2018 Banting Medal for Scientific Achievement, the highest honor of the American Diabetes Association (ADA). Shulman will be recognized for this honor and deliver his Banting Medal Lecture, “Mechanisms of Insulin Resistance: Implications for Obesity, Lipodystrophy and Type 2 Diabetes,” at the ADA’s 78th Scientific Sessions in Orlando, Florida, June 22-26.
Study: Topical antibiotic triggers unexpected antiviral response
A Yale-led research team made a startling discovery while investigating the effect of bacteria on viral infections. When they applied a common topical antibiotic to mice before or shortly after infection with herpes and other viruses, they found that the antibiotic triggered an antiviral resistance in the animals, the researchers said.
Yale Center for Biomedical Data Science is about ‘positive impact’
Big data is getting bigger. By 2025, genomics will have surpassed astronomy, Twitter, and YouTube to become the largest data-generating enterprise by far. What began 65 years ago when Watson, Crick, and Franklin unlocked the double helix of DNA has become, in just the past few years, an exponentially growing archive of individual genomes. Yale’s Center for Genome Analysis actually holds the ninth largest genomic library in the world.
Leptin hormone spurs body’s shift from burning carbs to fat
To keep the human brain supplied with energy when food was scarce, mammals evolved the ability to switch from burning carbohydrates to burning fat in order to preserve skeletal muscle that would otherwise be metabolized and converted to glucose. Scientists have long believed that the transition to fat metabolism was instigated solely by a drop in insulin. But a new study has identified leptin — a hormone made by fat cells — as a key mediator in this fundamental biological process.
Aging impairs innate immune response to flu
Aging impairs the immune system’s response to the flu virus in multiple ways, weakening resistance in older adults, according to a Yale study. The research reveals why older people are at increased risk of illness and death from flu, the researchers said.
Lifespan Research: Impact of Childhood Disease on Adult Health
YCCI’s renewed CTSA grant award allows Yale to continue its leadership in cutting-edge areas of research. One such novel initiative under the grant renewal is Diseases Across the Lifespan, which will explore the rising field of lifespan research — a new approach to examining the ways in which diseases that commonly strike adults have their roots in infancy and early childhood.
Thyroid hormone therapy heals lung fibrosis in animal study
Thyroid hormone therapy significantly resolves fibrosis, or scarring, in the lungs of mice, increasing their survival from disease, a Yale-led study shows. This provides a novel insight into the development of pulmonary fibrosis and could lead to alternative treatment for this serious condition, according to the researchers.
Study reveals how a very low calorie diet can reverse type 2 diabetes
In a new study, a Yale-led research team uncovers how a very low calorie diet can rapidly reverse type 2 diabetes in animal models. If confirmed in people, the insight provides potential new drug targets for treating this common chronic disease, said the researchers.
Battling belly fat: Specialized immune cells impair metabolism in aging
In a new study, Yale researchers have described how nervous systems and immune systems talk to each other to control metabolism and inflammation. Their finding furthers scientists’ understanding of why older adults fail to burn stored belly fat, which raises the risk of chronic disease. The study also points to potential therapeutic approaches to target the problem, the researchers said.
Yale Scientist Aiming To Reverse Spinal Cord Injuries
A Yale neurology and neuroscience professor who hopes to regrow neurons in patients with spinal cord injuries has secured enough funding for a human clinical trial. Stephen Strittmatter’s New Haven-based company, ReNetX, also has a new CEO, Erika Smith, who joined the biomedical venture in June after leaving her post as director of Yale University’s $10-million Blavatnik Fund for Innovation.Source: Hartford Courant