New Yale Initiative Looks Beyond Life Span to Increase Years of Health
Aging is a major risk factor for most chronic conditions, evidence shows, yet much of current research focuses on addressing specific diseases. The new Translational Geroscience Initiative at Yale School of Medicine (YSM) seeks to change that approach by studying the effects of aging on various ailments.
Platelet response to influenza vaccination reflects effects of aging
A paper whose authors include several Yale School of Medicine professors, researchers and scientists recently made the cover of Aging Cell. The cover design is by Hannah Wang, Academic Support Associate, Department of Pathology.Source: Aging Cell
Yale Researchers Awarded $12M NIH Grant to Study Impact of FGF21 Protein on Aging
Researchers from Yale University, and the University of Texas Southwestern Medical Center have been awarded a $12.4 million, five-year grant from the National Institute on Aging of the NIH to deploy their unique research models and expertise in a coordinated fashion to develop a novel course of gerontological research.
Calorie Reduction Lowers Protein Linked to the Aging Process
In a new study, Yale researchers show that moderate calorie restriction in people reduces the production of a protein called SPARC, which then reins in harmful inflammation and improves health in the aged. It could be a target for extending human health span, they report.
Biology of Aging Study Shows Why Curbing Calories Counts
The Director of the National Institutes of Health notes two recent studies, including one from the Yale Center for Research on Aging (Y-Age), that suggest that calorie restriction may improve immune function and reduce chronic inflammation.Source: National Institute of Health Director's Blog
Vishwa Deep Dixit Elected to Connecticut Academy of Science and Engineering
Vishwa Deep Dixit, DVM, PhD, Director of the Yale Center for Research on Aging (Y-Age), has been elected to the Connecticut Academy of Science and Engineering, a non-profit institution formed nearly 50 years ago to promote the application of science and technology to human welfare and economic well-being.
Vishwa Deep Dixit, DVM, PhD, Appointed Director of the Yale Center for Research on Aging (Y-Age) and Professor of Pathology at Yale Pathology
Vishwa Deep Dixit, DVM, PhD, the Waldemar Von Zedtwitz Professor of Comparative Medicine and Immunobiology at Yale School of Medicine, will be appointed as Director of the Yale Center for Research on Aging (Y-Age) and Professor of Pathology on January 1, 2022.
You have two ages, chronological and biological. Here's why it matters
Essentially, everyone has two ages: a chronological age, how old the calendar says you are, and a phenotypic or biological age, basically the age at which your body functions as it compares to average fitness or health levels. Levine and her team identified nine biomarkers taken in a simple blood test that seemed to be the most influential on lifespan. The biomarkers include blood sugar, kidney and liver measures, and immune and inflammatory measures. Levine plugs those numbers into the computer, and the algorithm does the rest. People with a biological age lower than their chronological age have a lower mortality risk, while those aging older from a biological standpoint have a higher mortality risk and are potentially more prone to developing the diseases associated with the higher age range.Source: CNN
Vishwa Deep Dixit appointed the Von Zedtwitz Professor of Comparative Medicine
Vishwa Deep Dixit, newly named as the Waldemar Von Zedtwitz Professor of Comparative Medicine, studies the interaction between immune and metabolic systems with the goal of revealing targets that can be harnessed to extend the healthspan — the period of life that is free of disabilities and disease.
Yale center dedicated to research on older adults receives renewed funding
For the fifth consecutive time, the Yale Claude D. Pepper Older Americans Independence Center (OAIC) has been renewed for funding from the National Institute on Aging (NIA). The Center is one of only two such programs nationwide to receive continuous NIA support since it was first funded in 1992, marking more than 25 years of excellence in geriatrics and aging research under the leadership of Geriatrics Section Chief Dr. Mary Tinetti, Dr. Thomas Gill, and Dr. Terri Fried.
Aging impairs innate immune response to flu
Aging impairs the immune system’s response to the flu virus in multiple ways, weakening resistance in older adults, according to a Yale study. The research reveals why older people are at increased risk of illness and death from flu, the researchers said.
Lifespan Research: Impact of Childhood Disease on Adult Health
YCCI’s renewed CTSA grant award allows Yale to continue its leadership in cutting-edge areas of research. One such novel initiative under the grant renewal is Diseases Across the Lifespan, which will explore the rising field of lifespan research — a new approach to examining the ways in which diseases that commonly strike adults have their roots in infancy and early childhood.
Battling belly fat: Specialized immune cells impair metabolism in aging
In a new study, Yale researchers have described how nervous systems and immune systems talk to each other to control metabolism and inflammation. Their finding furthers scientists’ understanding of why older adults fail to burn stored belly fat, which raises the risk of chronic disease. The study also points to potential therapeutic approaches to target the problem, the researchers said.
Earlier hospice care would improve quality of end of life
Older, terminally ill patients could improve the quality of their last days by accessing hospice services much sooner, according to a Yale School of Medicine-led study. The study found that, while Medicare covers hospice when a patient is given a prognosis of six months or less to live, most patients don’t turn to the services until the very end of life. The prognosis is made according to Medicare criteria for each condition. “I think the main message is that there are opportunities to improve care at the end of life in terms of addressing bothersome symptoms … through earlier referral to hospice,” said Dr. Thomas Gill, professor of geriatric medicine and director of the Yale Program on Aging, who is the study’s first author.Source: New Haven Register
Benefits of testosterone therapy in older men are mixed
Older men with low testosterone levels showed improved bone density and strength, as well as reduced anemia, after one year of testosterone therapy, according to a new study conducted at Yale and other sites. The therapy had no impact on cognitive function, however, and may worsen plaque in coronary arteries, said the researchers.
Seniors who go to emergency room at greater risk of decline
Senior citizens who are treated in the emergency department and sent home are at higher risk of disability and worsening health within the next six months, according to research published Friday by Yale physicians.Source: New Haven Register