2008
N-acylphosphatidylethanolamine, a Gut- Derived Circulating Factor Induced by Fat Ingestion, Inhibits Food Intake
Gillum MP, Zhang D, Zhang XM, Erion DM, Jamison RA, Choi C, Dong J, Shanabrough M, Duenas HR, Frederick DW, Hsiao JJ, Horvath TL, Lo CM, Tso P, Cline GW, Shulman GI. N-acylphosphatidylethanolamine, a Gut- Derived Circulating Factor Induced by Fat Ingestion, Inhibits Food Intake. Cell 2008, 135: 813-824. PMID: 19041747, PMCID: PMC2643061, DOI: 10.1016/j.cell.2008.10.043.Peer-Reviewed Original ResearchConceptsFood intakeInhibits food intakeTreatment of obesityNovel therapeutic targetCentral nervous systemUnknown physiological significanceFat ingestionCirculating factorsN-acylphosphatidylethanolaminePlasma lipidsIntracerebroventricular infusionPhysiologic dosesSystemic administrationTherapeutic targetBody weightNervous systemIngested fatSmall intestineIntakeTaste aversionInfusionPhysiological significanceNanomolar amountsObesityHypothalamus
2007
Neurobiology of Feeding and Energy Expenditure
Gao Q, Horvath TL. Neurobiology of Feeding and Energy Expenditure. Annual Review Of Neuroscience 2007, 30: 367-398. PMID: 17506645, DOI: 10.1146/annurev.neuro.30.051606.094324.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAppetite RegulationEnergy MetabolismFeeding BehaviorHormonesHumansHypothalamusLeptinMelanocortinsMotivationNeural PathwaysConceptsEnergy expenditureNeurobiology of feedingPeripheral metabolic signalsBrain homeostatic systemsMechanism of actionBrain involvementChronic regulationPharmacological techniquesNeuronal controlNeuronal mechanismsEnergy homeostasisComplex feeding behaviorHomeostatic systemMetabolic signalsFeeding behaviorInvolvementCurrent understandingBrain
2006
Thoughts for Food: Brain Mechanisms and Peripheral Energy Balance
Abizaid A, Gao Q, Horvath TL. Thoughts for Food: Brain Mechanisms and Peripheral Energy Balance. Neuron 2006, 51: 691-702. PMID: 16982416, DOI: 10.1016/j.neuron.2006.08.025.Peer-Reviewed Original ResearchThe unfolding cannabinoid story on energy homeostasis: central or peripheral site of action?
Horvath TL. The unfolding cannabinoid story on energy homeostasis: central or peripheral site of action? International Journal Of Obesity 2006, 30: s30-s32. PMID: 16570102, DOI: 10.1038/sj.ijo.0803275.Peer-Reviewed Original ResearchConceptsBlood-brain barrierCB1 receptor antagonistCentral endocannabinoid systemBody weight regulationWhite adipose tissueCentral nervous systemMesolimbic reward circuitryObserved beneficial effectsEnergy metabolism regulationAnorectic effectPeripheral actionsReceptor antagonistEndocannabinoid systemCB1 antagonistCB1 receptorsBrain sitesCannabinoid actionFood intakeHuman trialsPeripheral tissuesMetabolic disordersWeight regulationAdipose tissueNervous systemPharmaceutical approaches
2005
The hardship of obesity: a soft-wired hypothalamus
Horvath TL. The hardship of obesity: a soft-wired hypothalamus. Nature Neuroscience 2005, 8: 561-565. PMID: 15856063, DOI: 10.1038/nn1453.Peer-Reviewed Original ResearchConceptsFood intakeMetabolic disordersEnergy expenditureHumoral responseHomeostatic feedback loopSynaptic plasticityBrain circuitryObesityCentral therapyMetabolic phenotypeCellular mechanismsBrain anatomyMetabolic cuesIntakeDisordersCurrent knowledgeMajor advancesHeavy tollMorbidityDiabetesHypothalamusTherapyCNSMortalityMetabolic processes
2000
Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats
Dube M, Horvath T, Kalra P, Kalra S. Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats. Peptides 2000, 21: 1557-1560. PMID: 11068104, DOI: 10.1016/s0196-9781(00)00311-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAppetite DepressantsAppetite RegulationCarrier ProteinsEatingFeeding BehaviorInjections, IntraventricularIntracellular Signaling Peptides and ProteinsMaleNaphthalenesNerve Tissue ProteinsNeuronsNeuropeptidesOrexin ReceptorsOrexinsPyrimidinesRatsRats, Sprague-DawleyReceptors, G-Protein-CoupledReceptors, NeuropeptideReceptors, Neuropeptide YSignal TransductionWeight GainConceptsOrexigenic peptideReceptor antagonistSated ratsNPY Y1 receptor antagonistNPY-producing neuronsPotent orexigenic peptideNPY Y5 receptor antagonistsY1 receptor antagonistY5 receptor antagonistsOrexin AIntracerebroventricular injectionY5 receptorsNeuropeptide YReceptor involvementFood intakeStimulate feedingNeuronsAntagonistRatsFeedingOrexinCurrent resultsFunctional linkHypothalamusNPY
1999
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*
Kalra S, Dube M, Pu S, Xu B, Horvath T, Kalra P. Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*. Endocrine Reviews 1999, 20: 68-100. PMID: 10047974, DOI: 10.1210/edrv.20.1.0357.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAppetite RegulationBody WeightHomeostasisHumansHypothalamusLeptinPeptidesProteinsConceptsOrexigenic signalsAppetite-regulating pathwaysInfluence of GABAHypothalamic regulation of body weightNeural timing mechanismNPY-induced feedingCirculating levels of leptinDevelopment of leptin resistanceRegulation of body weightManagement of energy homeostasisCirculating leptin levelsSCN of rodentsLevels of leptinTiming mechanismInterruption of neurotransmissionExpression of NPYNeural mechanismsLeptin gene expressionNeural eventsNeural sitesGene expressionDaily pattern of feedingIngestive behaviorPattern of feedingPostsynaptic level