2023
Impaired Ghrelin Signaling Does Not Lead to Alterations of Anxiety-like Behaviors in Adult Mice Chronically Exposed to THC during Adolescence
Sestan-Pesa M, Shanabrough M, Horvath T, Miletta M. Impaired Ghrelin Signaling Does Not Lead to Alterations of Anxiety-like Behaviors in Adult Mice Chronically Exposed to THC during Adolescence. Biomedicines 2023, 11: 144. PMID: 36672651, PMCID: PMC9855766, DOI: 10.3390/biomedicines11010144.Peer-Reviewed Original ResearchAnxiety-like behaviorGrowth hormone secretagogue receptorTHC exposureAdult miceGHSR knockout miceDepression-like behaviorLate adolescenceWild-type littermatesLong-term useGHSR signalingGhrelin signalingSecretagogue receptorKnockout miceAnimal modelsTetrahydrocannabinol (THC) administrationMental illnessMiceSignificant alterationsGhrelinMarijuana useAdolescenceReceptorsProlonged periodExposureLong-term impact
2013
Natural birth-induced UCP2 in brain development
Seli E, Horvath TL. Natural birth-induced UCP2 in brain development. Reviews In Endocrine And Metabolic Disorders 2013, 14: 347-350. PMID: 23979530, DOI: 10.1007/s11154-013-9262-8.Peer-Reviewed Original ResearchConceptsVaginal birthPost-operative surgical careLong-term outcomesEarly postnatal periodWild-type littermatesAdult brain structureUCP2 mRNA expressionTerm outcomesSurgical techniqueSurgical carePostnatal periodSurgical meansHippocampal formationMore deliveriesSynapse formationAxonal outgrowthC-sectionKnockout animalsMRNA expressionUCP2 expressionBrain developmentBrain structuresNeuronal differentiationBirthHippocampus
2011
Reduced locomotor responses to cocaine in ghrelin-deficient mice
Abizaid A, Mineur YS, Roth RH, Elsworth JD, Sleeman MW, Picciotto MR, Horvath TL. Reduced locomotor responses to cocaine in ghrelin-deficient mice. Neuroscience 2011, 192: 500-506. PMID: 21699961, DOI: 10.1016/j.neuroscience.2011.06.001.Peer-Reviewed Original ResearchConceptsGhrelin KO miceWT miceDopamine releaseLocomotor activityBehavioral effectsDopamine metabolite concentrationsGhrelin-deficient miceLocomotor-stimulating effectsDopamine cell activityEffects of cocaineMesolimbic dopaminergic systemWild-type littermatesOrexigenic hormoneChronic injectionsDopamine utilizationDaily injectionsStriatal dopamineMesolimbic systemWT littermatesDopaminergic systemDaily cocaineFood intakeRewarding effectsPsychostimulant effectsLocomotor response
2009
Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice
Blum ID, Patterson Z, Khazall R, Lamont EW, Sleeman MW, Horvath TL, Abizaid A. Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice. Neuroscience 2009, 164: 351-359. PMID: 19666088, PMCID: PMC2996828, DOI: 10.1016/j.neuroscience.2009.08.009.Peer-Reviewed Original ResearchConceptsAnticipatory locomotor activityGHSR KO miceLocomotor activityKO miceGhrelin receptor deficient miceReceptor-deficient miceFeeding scheduleFos expression patternsWild-type littermatesRestricted feeding scheduleGhrelin receptor geneGhrelin injectionOrexigenic hormoneFos immunoreactivityHypothalamic nucleiDeficient miceLocomotor responseGhrelinH dailyMiceReceptor geneMealH patternTargeted mutationsBehavioral measures
2008
Overexpression of UCP2 Protects Thalamic Neurons following Global Ischemia in the Mouse
Olsson T, Wieloch T, Diano S, Warden CH, Horvath TL, Mattiasson G. Overexpression of UCP2 Protects Thalamic Neurons following Global Ischemia in the Mouse. Cerebrovascular And Brain Metabolism Reviews 2008, 28: 1186-1195. PMID: 18301432, PMCID: PMC2642535, DOI: 10.1038/jcbfm.2008.8.Peer-Reviewed Original ResearchConceptsGlobal ischemiaHistologic damageNeurodegenerative diseasesDentate gyrus hippocampal subfieldGlobal brain ischemiaSelective neuronal deathWild-type littermatesDays of recoveryCell deathNeuronal damageOverexpression of UCP2Brain ischemiaHistopathological outcomeSublethal ischemiaThalamic neuronsNeuronal deathThalamic nucleiWT animalsThalamic regionsHippocampal subfieldsIschemiaExtensive cell deathUCP2 expressionThalamusLevels of UCP2
2003
Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice
Horvath TL, Diano S, Miyamoto S, Barry S, Gatti S, Alberati D, Livak F, Lombardi A, Moreno M, Goglia F, Mor G, Hamilton J, Kachinskas D, Horwitz B, Warden CH. Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice. International Journal Of Obesity 2003, 27: 433-442. PMID: 12664076, DOI: 10.1038/sj.ijo.0802257.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsBasal MetabolismBlotting, NorthernBlotting, WesternBody TemperatureCarrier ProteinsCholesterol, LDLEnergy IntakeGene Expression RegulationHeart RateInflammationIon ChannelsMaleMembrane Transport ProteinsMiceMice, Inbred C57BLMice, TransgenicMitochondriaMitochondrial ProteinsObesityProteinsUncoupling Protein 2Uncoupling Protein 3ConceptsTransgenic miceFat massLow-density lipoprotein cholesterol levelsHeterozygous miceAgouti obese miceHypothalamic neuropeptide levelsSpontaneous physical activityLipoprotein cholesterol levelsNontransgenic littermate controlsFat pad weightEndotoxin-induced feverWild-type littermatesHuman UCP2Significant differencesMechanism of actionLDL cholesterolControl miceFemale transgenicsNontransgenic littermatesObese miceEndotoxin injectionCholesterol levelsPad weightNeuropeptide levelsFood intake