2021
Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles
Wu XS, Subramanian S, Zhang Y, Shi B, Xia J, Li T, Guo X, El-Hassar L, Szigeti-Buck K, Henao-Mejia J, Flavell RA, Horvath TL, Jonas EA, Kaczmarek LK, Wu LG. Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles. Neuron 2021, 109: 938-946.e5. PMID: 33508244, PMCID: PMC7979485, DOI: 10.1016/j.neuron.2021.01.006.Peer-Reviewed Original ResearchConceptsSlow endocytosisVesicle mobilizationF-actin cytoskeletonChannel mutationsPotassium channelsKv3.3 proteinsInhibits endocytosisRapid endocytosisNovel functionF-actinEndocytosisCrucial functionSynaptic vesiclesFamily channelsSynaptic transmissionDiscovery decadesMembrane potentialNeurotransmitter releaseDiverse neurological disordersIon conductanceMutationsReleasable poolMouse nerve terminalsPotassium channel mutationsPathological effects
2020
Impaired hypocretin/orexin system alters responses to salient stimuli in obese male mice
Tan Y, Hang F, Liu ZW, Stoiljkovic M, Wu M, Tu Y, Han W, Lee AM, Kelley C, Hajos M, Lu L, de Lecea L, de Araujo I, Picciotto M, Horvath TL, Gao XB. Impaired hypocretin/orexin system alters responses to salient stimuli in obese male mice. Journal Of Clinical Investigation 2020, 130: 4985-4998. PMID: 32516139, PMCID: PMC7456212, DOI: 10.1172/jci130889.Peer-Reviewed Original ResearchConceptsHcrt cellsObese miceDiet-induced obese miceObese male miceExcessive energy intakeNeuropeptide hypocretin/orexinHypocretin/orexinHcrt neuronsMale miceHcrt systemClinical studiesCommon causeSynaptic transmissionObese animalsEnergy intakeAcute stressCognitive functionSalient stimuliAlters responsesExact mechanismMiceHomeostatic regulationNeuronal networksBehavioral changesNeurons
2016
The role of astrocytes in the hypothalamic response and adaptation to metabolic signals
Chowen JA, Argente-Arizón P, Freire-Regatillo A, Frago LM, Horvath TL, Argente J. The role of astrocytes in the hypothalamic response and adaptation to metabolic signals. Progress In Neurobiology 2016, 144: 68-87. PMID: 27000556, DOI: 10.1016/j.pneurobio.2016.03.001.Peer-Reviewed Original ResearchConceptsHypothalamic responseMetabolic signalsRole of astrocytesIncidence of obesityAnorexigenic hormone leptinType 2 diabetesHypothalamic adaptationsImportant metabolic signalsDiabetes mellitusHypothalamic circuitsSecondary complicationsChronic conditionsHormone leptinGlial cellsSynaptic transmissionAdequate treatmentMetabolic diseasesSynaptic plasticityNeuroendocrine controlHomeostatic functionsNeighboring neuronsMetabolic homeostasisHormonal inputsObesityHypothalamus
2010
A Sympathetic View on Free Radicals in Diabetes
Diano S, Horvath TL. A Sympathetic View on Free Radicals in Diabetes. Neuron 2010, 66: 809-811. PMID: 20620864, DOI: 10.1016/j.neuron.2010.06.011.Peer-Reviewed Original ResearchPotential novel therapeutic approachHyperglycemia-induced elevationImpairs synaptic transmissionNovel therapeutic approachesSevere complicationsDiabetic complicationsSympathetic neuronsSynaptic transmissionTherapeutic approachesIssue of NeuronNeuropathyComplicationsDiabetesNeuronsFree radicalsDysautonomiaEtiology
2005
Mitochondrial uncoupling proteins in the cns: in support of function and survival
Andrews ZB, Diano S, Horvath TL. Mitochondrial uncoupling proteins in the cns: in support of function and survival. Nature Reviews Neuroscience 2005, 6: 829-840. PMID: 16224498, DOI: 10.1038/nrn1767.Peer-Reviewed Original ResearchConceptsNeuronal functionNeurological disordersTraumatic brain injuryAmyotrophic lateral sclerosisClinical treatment strategiesMitochondrial calcium influxModels of neurodegenerationMitochondrial uncouplingFree radical productionReactive oxygen species productionNeuronal deteriorationNeuronal deathSubstantia nigraBrain injurySpinal cordVentral tegmentumTreatment strategiesOxygen species productionNeuronal microenvironmentSynaptic transmissionCalcium influxLimbic systemNeurological conditionsLateral sclerosisParkinson's disease