2023
Impaired Ghrelin Signaling Does Not Lead to Alterations of Anxiety-like Behaviors in Adult Mice Chronically Exposed to THC during Adolescence
Sestan-Pesa M, Shanabrough M, Horvath T, Miletta M. Impaired Ghrelin Signaling Does Not Lead to Alterations of Anxiety-like Behaviors in Adult Mice Chronically Exposed to THC during Adolescence. Biomedicines 2023, 11: 144. PMID: 36672651, PMCID: PMC9855766, DOI: 10.3390/biomedicines11010144.Peer-Reviewed Original ResearchAnxiety-like behaviorGrowth hormone secretagogue receptorTHC exposureAdult miceGHSR knockout miceDepression-like behaviorLate adolescenceWild-type littermatesLong-term useGHSR signalingGhrelin signalingSecretagogue receptorKnockout miceAnimal modelsTetrahydrocannabinol (THC) administrationMental illnessMiceSignificant alterationsGhrelinMarijuana useAdolescenceReceptorsProlonged periodExposureLong-term impact
2015
Ghrelin
Müller T, Nogueiras R, Andermann M, Andrews Z, Anker S, Argente J, Batterham R, Benoit S, Bowers C, Broglio F, Casanueva F, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole P, Cowley M, Cummings D, Dagher A, Diano S, Dickson S, Diéguez C, Granata R, Grill H, Grove K, Habegger K, Heppner K, Heiman M, Holsen L, Holst B, Inui A, Jansson J, Kirchner H, Korbonits M, Laferrère B, LeRoux C, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger P, Schwartz T, Seeley R, Sleeman M, Sun Y, Sussel L, Tong J, Thorner M, van der Lely A, van der Ploeg L, Zigman J, Kojima M, Kangawa K, Smith R, Horvath T, Tschöp M. Ghrelin. Molecular Metabolism 2015, 4: 437-460. PMID: 26042199, PMCID: PMC4443295, DOI: 10.1016/j.molmet.2015.03.005.Peer-Reviewed Original ResearchGastrointestinal peptide hormone ghrelinGrowth hormone secretagogue receptorSleep/wake rhythmGastric acid secretionSystemic energy metabolismPeptide hormone ghrelinPeripheral actionsGut motilitySecretagogue receptorHormone ghrelinAcid secretionGlucose metabolismGhrelinEndogenous ligandTaste sensationEnergy metabolismSecretionMetabolismDiverse biological functionsYearsHormone
2008
Ghrelin: an orexigenic signal from the stomach
Horvath T. Ghrelin: an orexigenic signal from the stomach. 2008, 266-284. DOI: 10.1017/cbo9780511541643.010.Peer-Reviewed Original ResearchEffects of ghrelinGrowth hormone secretagoguesFood intakeGrowth hormoneGrowth hormone secretagogue receptorDiscovery of ghrelinAmino acid peptide hormoneAnorectic hormonesOrexigenic signalsGhrelin actionPeripheral mechanismsSecretagogue receptorMetabolic effectsHormone secretagoguesBody fatGhrelinPeripheral signalsEndogenous ligandStimulatory effectEnergy expenditurePeptide hormonesCell proliferationIntakeHormoneHormonal regulation
2004
Novel analogs of ghrelin: physiological and clinical implications
Halem H, Taylor J, Dong J, Shen Y, Datta R, Abizaid A, Diano S, Horvath T, Zizzari P, Bluet-Pajot M, Epelbaum J, Culler M. Novel analogs of ghrelin: physiological and clinical implications. European Journal Of Endocrinology 2004, 151: s71-s75. PMID: 15339248, DOI: 10.1530/eje.0.151s071.Peer-Reviewed Original ResearchConceptsBIM-28163GH secretionGHS receptorWeight gainNeuronal activationGrowth hormone secretagogue receptorAntagonist of ghrelinAction of ghrelinNormal GH secretionRole of ghrelinStimulation of feedingActivity of ghrelinPotential therapeutic benefitAnalogues of ghrelinNative ghrelinEndogenous ghrelinGhrelin actionGH levelsHypothalamic GHHypothalamic sitesSecretagogue receptorGhrelin receptorFood intakeNormal ratsGhrelin analogs