2021
Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes
Ravindra NG, Alfajaro MM, Gasque V, Huston NC, Wan H, Szigeti-Buck K, Yasumoto Y, Greaney AM, Habet V, Chow RD, Chen JS, Wei J, Filler RB, Wang B, Wang G, Niklason LE, Montgomery RR, Eisenbarth SC, Chen S, Williams A, Iwasaki A, Horvath TL, Foxman EF, Pierce RW, Pyle AM, van Dijk D, Wilen CB. Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes. PLOS Biology 2021, 19: e3001143. PMID: 33730024, PMCID: PMC8007021, DOI: 10.1371/journal.pbio.3001143.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionSARS-CoV-2Human bronchial epithelial cellsInterferon-stimulated genesCell state changesAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSyndrome coronavirus 2 infectionCell tropismCoronavirus 2 infectionCoronavirus disease 2019Onset of infectionCell-intrinsic expressionCourse of infectionAir-liquid interface culturesHost-viral interactionsBronchial epithelial cellsSingle-cell RNA sequencingCell typesIL-1Disease 2019Human airwaysDevelopment of therapeuticsDrug AdministrationViral replication
2017
Molecular and cellular reorganization of neural circuits in the human lineage
Sousa AMM, Zhu Y, Raghanti MA, Kitchen RR, Onorati M, Tebbenkamp ATN, Stutz B, Meyer KA, Li M, Kawasawa YI, Liu F, Perez RG, Mele M, Carvalho T, Skarica M, Gulden FO, Pletikos M, Shibata A, Stephenson AR, Edler MK, Ely JJ, Elsworth JD, Horvath TL, Hof PR, Hyde TM, Kleinman JE, Weinberger DR, Reimers M, Lifton RP, Mane SM, Noonan JP, State MW, Lein ES, Knowles JA, Marques-Bonet T, Sherwood CC, Gerstein MB, Sestan N. Molecular and cellular reorganization of neural circuits in the human lineage. Science 2017, 358: 1027-1032. PMID: 29170230, PMCID: PMC5776074, DOI: 10.1126/science.aan3456.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptomic dataDistinct functional categoriesDistinct cell typesBiosynthesis genesTranscriptome sequencingHuman lineageTranscriptomic dataFunctional categoriesCellular reorganizationExpression differencesPhylogenetic reorganizationFunctional analysisCell typesGenesCellular featuresCellular differencesHuman specificityNeural circuitsLineagesMultiple levelsReorganizationSequencingHumansChimpanzeesAdult humans
2012
Phosphoribosomes for Fingerprinting Neurons
Dietrich MO, Horvath TL. Phosphoribosomes for Fingerprinting Neurons. Cell 2012, 151: 934-936. PMID: 23178116, DOI: 10.1016/j.cell.2012.11.006.Peer-Reviewed Original Research
2003
Mitochondrial Uncoupling Proteins: Regulators of Retinal Cell Death
Barnstable CJ, Li M, Reddy R, Horvath TL. Mitochondrial Uncoupling Proteins: Regulators of Retinal Cell Death. Advances In Experimental Medicine And Biology 2003, 533: 269-275. PMID: 15180273, DOI: 10.1007/978-1-4615-0067-4_33.Peer-Reviewed Original ResearchConceptsOxidative stressElevated levelsOptic nerve disordersGanglion cell deathCell deathRetinal cell deathSuch elevated levelsNerve disordersInner retinaNeuronal degenerationReactive oxygen radicalsMetabolic conditionsNeural componentsApoptotic cell deathOxygen radicalsIntracellular metabolismDeathSpecific mutationsCell typesExtensive evidenceIrreversible cascadeGlaucomaDegenerationRetina
1999
Estrogen and microglia: A regulatory system that affects the brain
Mor G, Nilsen J, Horvath T, Bechmann I, Brown S, Garcia‐Segura L, Naftolin F. Estrogen and microglia: A regulatory system that affects the brain. Developmental Neurobiology 1999, 40: 484-496. PMID: 10453051, DOI: 10.1002/(sici)1097-4695(19990915)40:4<484::aid-neu6>3.0.co;2-c.Peer-Reviewed Original ResearchConceptsSex hormonesRat microglial cellsSecretion of cytokinesPresence of estrogenGlial cell typesMicroglial functionEstrogen actionMicroglial cellsGonadal steroidsGlial cellsSteroid actionNeuroendocrine eventsMicrogliaPresent review detailsGrowth factorEstrogenBrainPhysiological regulationHormoneCell typesReview detailsNew studiesRegulatory actionCellsRegulatory functions