https://medicine.yale.edu/y-weight/news-rss/?title=Latest%20News&orgId=122395 A selection of the latest research, academic, and other newsworthy developments at Yale Obesity Research Center (Y-Weight) en-us Copyright 2026 Yale School of Medicine Mon, 10 Aug 2026 01:50:58 Z https://medicine.yale.edu/ysm/yale-medicine-magazine/article/what-mitochondria-really-do/ https://medicine.yale.edu/ysm/yale-medicine-magazine/article/what-mitochondria-really-do/ Yale School of Medicine researchers explore the many functions of mitochondria—and how their malfunction can contribute to a broad range of diseases. Mon, 25 May 2026 04:00:00 Z https://www.nytimes.com/2026/05/21/science/retatrutide-weight-loss-drug.html https://www.nytimes.com/2026/05/21/science/retatrutide-weight-loss-drug.html People who got the injection, retatrutide, lost 28 percent of their body weight on average after 80 weeks, Eli Lilly said. Fri, 22 May 2026 04:00:00 Z https://people.com/eli-lilly-retatrutide-new-drug-dramatic-weight-loss-results-11981402 https://people.com/eli-lilly-retatrutide-new-drug-dramatic-weight-loss-results-11981402 In a clinical trial, the new weight-loss medication retatrutide led to "clinically meaningful weight reduction," with the highest dose linked to a 30% reduction in average body weight. Thu, 21 May 2026 04:00:00 Z https://www.dailymail.co.uk/news/article-15838447/New-drug-curbs-appetite-burns-calories-powerful-weight-loss-treatment-like-exercise-jab.html https://www.dailymail.co.uk/news/article-15838447/New-drug-curbs-appetite-burns-calories-powerful-weight-loss-treatment-like-exercise-jab.html A new drug that curbs appetite and helps users burn more calories is the most powerful weight-loss treatment ever, a major trial reveals. Thu, 21 May 2026 04:00:00 Z https://www.nytimes.com/2026/04/27/health/food-noise-obesity-drugs-glp-1.html https://www.nytimes.com/2026/04/27/health/food-noise-obesity-drugs-glp-1.html Before the new obesity drugs came on the market, almost no one used the term food noise. If researchers can clarify the source of this inner buzz and what makes it go away, that could lead to a clearer understanding of what causes obesity in the first place. Mon, 27 Apr 2026 04:00:00 Z https://www.oprahdaily.com/life/health/a70791946/retatrutide-triple-agonist-medications/ https://www.oprahdaily.com/life/health/a70791946/retatrutide-triple-agonist-medications/ “We’ve never seen weight loss at this level before,” says Ania Jastreboff, MD, PhD, the director of the Yale Obesity Research Center at the Yale School of Medicine, who has been involved in research on the drug. Fri, 27 Mar 2026 04:00:00 Z https://www.sciencedaily.com/releases/2026/03/260307213228.htm https://www.sciencedaily.com/releases/2026/03/260307213228.htm In a recent study, researchers found that lowering parent stress can help protect young children from obesity. When parents practiced mindfulness and stress-management skills, their children showed healthier eating patterns and avoided the weight gain seen in families that only focused on diet and exercise. The study was led by Yale Child Study Center faculty members Rajita Sinha, PhD, and Wendy Silverman, PhD, with Professor of Medicine Ania Jastreboff, MD, PhD. Jastrebroff also serves as the medical director at Yale Stress Center. Sun, 08 Mar 2026 05:00:00 Z https://news.yale.edu/2026/03/04/enough-blame-and-shame-science-behind-obesity-and-glp-1s https://news.yale.edu/2026/03/04/enough-blame-and-shame-science-behind-obesity-and-glp-1s In a new book, Yale endocrinologist Ania Jastreboff teams up with Oprah Winfrey to transform how we think about health, weight, and obesity. Wed, 04 Mar 2026 20:00:00 Z https://medicine.yale.edu/y-weight/news-article/stigma-to-science/ https://medicine.yale.edu/y-weight/news-article/stigma-to-science/ Yale research helped redefine obesity as a chronic metabolic disease and advanced next-generation treatments. Tue, 24 Feb 2026 05:00:00 Z https://people.com/people-best-books-of-january-2026-11882394:// https://people.com/people-best-books-of-january-2026-11882394:// In a new book (Enough) co-written with endocrinologist Ania M. Jastreboff, Oprah Winfrey reflects on her weight loss journey, using conversations with Jastreboff as a launching point to teach readers how to navigate their own. Sun, 01 Feb 2026 05:00:00 Z https://www.youtube.com/watch?v=aFCaYyKUUKQ https://www.youtube.com/watch?v=aFCaYyKUUKQ Winfrey discusses her biggest regret from her many years on television and shares the message behind her new book with Dr. Ania Jastreboff, 'Enough: Your Health, Your Weight, and What It's Like To Be Free.' Wed, 14 Jan 2026 05:00:00 Z https://www.today.com/video/oprah-winfrey-on-how-she-found-new-freedom-after-weight-loss-255869509965 https://www.today.com/video/oprah-winfrey-on-how-she-found-new-freedom-after-weight-loss-255869509965 Oprah Winfrey sits down with TODAY’s Jenna Bush Hager and Sheinelle Jones to talk about her new book “Enough: Your Health, Your Weight, and What It’s Like to Be Free” about her weight loss, the lifestyle changes she experienced, why the journey gave her a new sense of freedom, and how she proved her dad wrong about obesity when she learned it is not the fault of people who suffer from it. Then, her co-author Dr. Ania M. Jastreboff, endocrinologist and associate professor at the Yale School of Medicine, joins the conversation to discuss how GLP-1s work. Tue, 13 Jan 2026 05:00:00 Z https://www.today.com/video/glp-1-drug-myths-debunked-side-effects-microdosing-more-255872069531 https://www.today.com/video/glp-1-drug-myths-debunked-side-effects-microdosing-more-255872069531 Dr. Ania Jastreboff, endocrinologist and co-author with Oprah Winfrey of their new book “Enough: Your Health, Your Weight, and What It’s Like to Be Free,” joins TODAY’s Jenna Bush Hager and Sheinelle Jones to debunk some common myths about weight loss medications. Myths include whether weight loss continues indefinitely, if the medications cure obesity altogether, whether microdosing is effective for people who do not have obesity and more. Tue, 13 Jan 2026 05:00:00 Z https://www.youtube.com/watch?v=g7pw3MJ7QVE https://www.youtube.com/watch?v=g7pw3MJ7QVE For her most of her adult life, Oprah has struggled with her weight. She never dreamed in her lifetime, there would be medications that could help her as well as millions of others. On this episode of The Oprah Podcast, Oprah is joined by Dr. Ania Jastreboff, leading endocrinologist and associate professor at Yale School of Medicine in front of a live audience in New York City. Tue, 13 Jan 2026 05:00:00 Z https://www.youtube.com/watch?v=ST3mnAcOrvw https://www.youtube.com/watch?v=ST3mnAcOrvw Oprah Winfrey is one of the best-known, most-admired and successful people on the planet. But for years she seemed powerless to conquer her fluctuating weight problem … until new medications, and a new attitude about her weight, gave her a breakthrough, which she describes in "Enough," a new book she has co-written with Dr. Ania Jastreboff. They talk with Jane Pauley about an individual's genetically-influenced weight range, and how to reset it. Winfrey also relates the long road she traveled since she began her TV career in Nashville, facing sexism, racism, and comments about her weight. Tue, 13 Jan 2026 05:00:00 Z https://people.com/oprah-opens-up-about-obesity-glp-1s-and-her-new-life-exclusive-11877105 https://people.com/oprah-opens-up-about-obesity-glp-1s-and-her-new-life-exclusive-11877105 In People's new cover story, Oprah Winfrey, who has cowritten a new book on obesity with Yale School of Medicine's Ania Jastreboff, MD, PhD,shares her past struggles — and what life is like now on weight loss drugs. Wed, 31 Dec 2025 05:00:00 Z https://people.com/oprah-s-co-author-says-the-icon-turned-blame-and-shame-she-faced-into-a-gift-for-people-with-obesity-11877236 https://people.com/oprah-s-co-author-says-the-icon-turned-blame-and-shame-she-faced-into-a-gift-for-people-with-obesity-11877236 Oprah Winfrey calls her new book with Yale School of Medicine's Ania Jastreboff, MD, PhD, a "public service." Wed, 31 Dec 2025 05:00:00 Z https://medicine.yale.edu/y-weight/news-article/meet-alexandra-tavakoli-yale-endocrinology-metabolism/ https://medicine.yale.edu/y-weight/news-article/meet-alexandra-tavakoli-yale-endocrinology-metabolism/ Meet Alexandra Tavakoli, an associate director of operations, who finds purpose in advancing research in obesity medicine within Yale Endocrinology & Metabolism. Thu, 04 Dec 2025 11:00:00 Z https://medicine.yale.edu/ysm/yale-medicine-magazine/article/the-glp-1-revolution/ https://medicine.yale.edu/ysm/yale-medicine-magazine/article/the-glp-1-revolution/ Glucagon-like peptide-1 (GLP-1) agonists are showing promise for reducing both cardiometabolic disease prevalence and obesity stigma. Mon, 01 Dec 2025 05:00:00 Z https://www.washingtonpost.com/health/2025/11/27/weight-loss-drugs-ozempic-pills-shots/ https://www.washingtonpost.com/health/2025/11/27/weight-loss-drugs-ozempic-pills-shots/ A new weight loss pill could come within months, with Ania Jastreboff, MD, PhD. Thu, 27 Nov 2025 05:00:00 Z https://www.wsj.com/health/thanksgiving-weight-loss-drugs-664dfd33 https://www.wsj.com/health/thanksgiving-weight-loss-drugs-664dfd33 Some people taking weight-loss drugs are delaying doses to eat a lot, while others are adjusting menus. With Ania Jastreboff, MD, PhD. Wed, 26 Nov 2025 05:00:00 Z https://medicine.yale.edu/y-weight/news-article/once-monthly-obesity-medication-shows-promise-for-those-with-and-without-type-2-diabetes/ https://medicine.yale.edu/y-weight/news-article/once-monthly-obesity-medication-shows-promise-for-those-with-and-without-type-2-diabetes/ A novel, dual-action anti-obesity medication is effective with less frequent dosing than currently available medications that target GLP-1. Thu, 17 Jul 2025 14:00:00 Z https://medicine.yale.edu/y-weight/news-article/new-professors-department-of-internal-medicine-june-2025/ https://medicine.yale.edu/y-weight/news-article/new-professors-department-of-internal-medicine-june-2025/ Congratulations to the new professors in the Department of Internal Medicine! Mon, 02 Jun 2025 04:00:00 Z https://medicine.yale.edu/y-weight/news-article/why-arent-people-who-need-weight-loss-drugs-getting-them/ https://medicine.yale.edu/y-weight/news-article/why-arent-people-who-need-weight-loss-drugs-getting-them/ Only 3% of eligible U.S. adults receive prescriptions for weight loss medications, according to research from Yale School of Medicine. Mon, 05 May 2025 14:00:00 Z https://www.wtnh.com/news/health/weight-loss-revolution-part-1-the-pros-and-cons-of-weight-loss-drugs/#:~:text=%E2%80%9CThey're%20a%20highly%20effective,include%20nausea%2C%20diarrhea%20and%20constipation. https://www.wtnh.com/news/health/weight-loss-revolution-part-1-the-pros-and-cons-of-weight-loss-drugs/#:~:text=%E2%80%9CThey're%20a%20highly%20effective,include%20nausea%2C%20diarrhea%20and%20constipation. Obesity is an epidemic in the United States, but more people are shedding pounds with the help of weight loss drugs. Wed, 12 Feb 2025 05:00:00 Z https://www.youtube.com/watch?v=_GEe8EUTfRk https://www.youtube.com/watch?v=_GEe8EUTfRk In this episode of The Oprah Podcast, Oprah sits down with Dr. Ania Jastreboff, an endocrinologist and associate professor at the Yale School of Medicine, to talk about the new GLP-1 medications like Ozempic, Wegovy, Mounjaro and Zepbound. Dr. Ania, who has been on the forefront of GLP-1 medication research for the past 20 years, will talk through why it is biologically difficult for some people to lose weight, maintain weight loss, and why obesity is a disease. She explains how the new GLP-1 medications work, how they can facilitate weight loss, and if they are safe. Dr. Ania answers questions from people around the country who are taking the GLP-medications and have lost a significant amount of weight. We will also share an update from Amy Kane who told her story of losing 160 pounds on weight loss medications last year on Oprah’s ABC Special: Shame, Blame and the Weight Loss Revolution. Tue, 14 Jan 2025 05:00:00 Z https://youtu.be/_GEe8EUTfRk?feature=shared https://youtu.be/_GEe8EUTfRk?feature=shared In this episode of The Oprah Podcast, Oprah sits down with Dr. Ania Jastreboff, an endocrinologist and associate professor at the Yale School of Medicine, to talk about the new GLP-1 medications like Ozempic, Wegovy, Mounjaro and Zepbound. Dr. Ania, who has been on the forefront of GLP-1 medication research for the past 20 years, will talk through why it is biologically difficult for some people to lose weight, maintain weight loss, and why obesity is a disease. She explains how the new GLP-1 medications work, how they can facilitate weight loss, and if they are safe. Dr. Ania answers questions from people around the country who are taking the GLP-medications and have lost a significant amount of weight. We will also share an update from Amy Kane who told her story of losing 160 pounds on weight loss medications last year on Oprah’s ABC Special: Shame, Blame and the Weight Loss Revolution. Tue, 14 Jan 2025 05:00:00 Z https://www.yahoo.com/news/health-headlines-glp-1-drugs-144523562.html https://www.yahoo.com/news/health-headlines-glp-1-drugs-144523562.html NEW HAVEN, Conn. (WTNH) In today's health headlines, can GLP-1 drugs reverse prediabetes? Plus, how to reduce food noise and stick to weight loss goals during Thanksgiving week. Dr. Ania Jastreboff, Yale Medicine endocrinologist and obesity medicine physician-scientist and director of the Yale Obesity Research Center at Yale School of Medicine, discussed these topics. Fri, 22 Nov 2024 05:00:00 Z https://www.healthday.com/healthpro-news/weight-loss/tirzepatide-yields-sustained-weight-reduction-in-obesity-prediabetes https://www.healthday.com/healthpro-news/weight-loss/tirzepatide-yields-sustained-weight-reduction-in-obesity-prediabetes MONDAY, Nov. 18, 2024 (HealthDay News) -- For patients with obesity and prediabetes, three years of tirzepatide yields substantial and sustained weight reductio Mon, 18 Nov 2024 05:00:00 Z https://insights.som.yale.edu/podcasts/health-veritas/ania-jastreboff-the-transformative-obesity-drugs?utm_source=YaleToday&utm_medium=email&utm_campaign=YT_YaleToday-Staff_9-25-2024 https://insights.som.yale.edu/podcasts/health-veritas/ania-jastreboff-the-transformative-obesity-drugs?utm_source=YaleToday&utm_medium=email&utm_campaign=YT_YaleToday-Staff_9-25-2024 Ania Jastreboff, MD, PhD, associate professor of medicine (endocrinology) at Yale School of Medicine, discusses the range of diseases treated by novel weight-loss drugs such as Ozempic, Mounjaro, and Wegovy. Thu, 19 Sep 2024 04:00:00 Z https://www.youtube.com/watch?v=kMI9b3_TWt0 https://www.youtube.com/watch?v=kMI9b3_TWt0 After more than 60 years of watching weight, we think it’s time to shift the role weight plays in our society. Dr. Ania Jastreboff is an endocrinologist and associate professor at the Yale School of Medicine. In this video, recorded during Oprah’s “Making the Shift: A New Way to Think About Weight,” she explains why obesity is defined as “a disease” (a neurometabolic disease, to be specific) and why that’s important for addressing its causes and treatments. She also discusses the facts and fiction about weight loss medications and why the option might be (or might not be) explored for some of her patients - and how you, and only you, can make the decision about what’s best for your health. Thu, 09 May 2024 09:00:00 Z https://www.nytimes.com/2024/03/18/well/live/oprah-ozempic-weight-loss.html https://www.nytimes.com/2024/03/18/well/live/oprah-ozempic-weight-loss.html Shame has become a focal point in that conversation as new drugs like Ozempic and Mounjaro, which are widely used for weight loss, shift how people think about treating obesity. Tue, 19 Mar 2024 04:00:00 Z https://medicine.yale.edu/y-weight/news-article/new-frontiers-in-obesity-research-at-yale/ https://medicine.yale.edu/y-weight/news-article/new-frontiers-in-obesity-research-at-yale/ Newly emerging, highly effective treatments and new discoveries regarding the pathophysiology of obesity provide promise for combating this growing epidemic. Wed, 06 Mar 2024 05:00:00 Z https://www.washingtonpost.com/washington-post-live/2024/02/13/improving-womens-heart-health-cardiovascular-care/ https://www.washingtonpost.com/washington-post-live/2024/02/13/improving-womens-heart-health-cardiovascular-care/ Alexandra Lansky, MD, professor of medicine (cardiovascular medicine), discusses how the new obesity medications can improve women's cardiovascular health. Tue, 13 Feb 2024 05:00:00 Z https://amp.cnn.com/cnn/2024/02/05/health/weight-loss-blood-pressure/index.html https://amp.cnn.com/cnn/2024/02/05/health/weight-loss-blood-pressure/index.html Harlan Krumholz, MD, Harold H. Hines, Jr. Professor of Medicine (Cardiology), discusses two new studies that show treatment of obesity may be instrumental in improving heart health. Mon, 05 Feb 2024 17:00:00 Z https://medicine.yale.edu/y-weight/news-article/obesity-is-not-a-choice-ania-jastreboff/ https://medicine.yale.edu/y-weight/news-article/obesity-is-not-a-choice-ania-jastreboff/ In a Q&A, Ania Jastreboff, MD, PhD, discusses the barriers to treating obesity, benefits of clinical trials, and the new era of obesity medicine. Mon, 05 Feb 2024 16:22:00 Z https://www.wtnh.com/video/health-headlines-what-to-know-about-muscle-loss-while-losing-weight/9325134/?ipid=promo-link-block1 https://www.wtnh.com/video/health-headlines-what-to-know-about-muscle-loss-while-losing-weight/9325134/?ipid=promo-link-block1 Ania Jastreboff, MD, PhD, Director, Yale Obesity Research Center (Y-Weight); Co-Director, Yale Center for Weight Management, is interviewed by WTNH-TV on muscle loss while losing weight. Fri, 12 Jan 2024 17:00:00 Z https://medicine.yale.edu/ysm/yale-medicine-magazine/article/the-next-era-of-obesity/ https://medicine.yale.edu/ysm/yale-medicine-magazine/article/the-next-era-of-obesity/ The next era of obesity medicine Wed, 01 Nov 2023 04:00:00 Z https://medicine.yale.edu/ysm/yale-medicine-magazine/article/new-anti-obesity-medications/ https://medicine.yale.edu/ysm/yale-medicine-magazine/article/new-anti-obesity-medications/ New anti-obesity medications are transforming the treatment of obesity. Wed, 01 Nov 2023 04:00:00 Z https://medicine.yale.edu/y-weight/news-article/beyond-ozempic-trials-hold-promise-for-highly-effective-obesity-drugs/ https://medicine.yale.edu/y-weight/news-article/beyond-ozempic-trials-hold-promise-for-highly-effective-obesity-drugs/ Yale researchers are seeing significant results in clinical trials involving the newest generation of anti-obesity medications. Fri, 30 Jun 2023 04:00:00 Z https://www.nature.com/articles/d41586-023-02092-9 https://www.nature.com/articles/d41586-023-02092-9 Two new drugs for treating obesity are on course to become available in the next few years — and they offer advantages beyond those of the highly effective blockbuster drugs already on the market. Tue, 27 Jun 2023 04:00:00 Z https://www.wsj.com/articles/pill-for-obesity-has-wall-street-salivating-da541db?mod=lead_feature_below_a_pos1 https://www.wsj.com/articles/pill-for-obesity-has-wall-street-salivating-da541db?mod=lead_feature_below_a_pos1 Obesity treatments are currently limited to injections, but pills could expand the market and lower costs. Mon, 26 Jun 2023 04:00:00 Z https://www.healthline.com/health-news/how-obesity-can-change-your-brain-and-make-it-harder-to-lose-weight https://www.healthline.com/health-news/how-obesity-can-change-your-brain-and-make-it-harder-to-lose-weight Mireille Serlie, MD, PhD, professor of medicine (endocrinology), found that brain changes related to obesity may impact whether or not people feel full after eating. Thu, 15 Jun 2023 04:00:00 Z https://www.nature.com/articles/d41586-023-01712-8 https://www.nature.com/articles/d41586-023-01712-8 A new generation of drugs is revolutionizing the treatment of obesity and astonishing researchers with their potency. Despite their high effectiveness, researchers are learning that these drugs are not necessarily the solution for everyone living with obesity. Tue, 23 May 2023 04:00:00 Z https://www.washingtonpost.com/health/2023/05/18/weight-loss-wegovy-ozempic-semaglutide/ https://www.washingtonpost.com/health/2023/05/18/weight-loss-wegovy-ozempic-semaglutide/ Just under half of obese adolescents administered the latest in a new generation of recently approved weight-loss drugs were no longer considered to be clinically obese by the end of a 16-month trial, a study found. The findings support a small but growing body of evidence that the drug semaglutide, which goes by the brand names of Ozempic and Wegovy, can be an effective treatment option for chronic weight management for a range of ages. Thu, 18 May 2023 04:00:00 Z https://www.wsj.com/articles/ozempic-wegovy-mounjaro-obesity-lilly-novo-nordisk-blockbuster-9b285303?mod=lead_feature_below_a_pos1 https://www.wsj.com/articles/ozempic-wegovy-mounjaro-obesity-lilly-novo-nordisk-blockbuster-9b285303?mod=lead_feature_below_a_pos1 Medications like Ozempic and Mounjaro are about to create one of the biggest drug categories of all time. Here’s why. Fri, 05 May 2023 04:00:00 Z https://www.motherjones.com/politics/2023/04/should-insurers-cover-kids-obesity-drugs-experts-say-its-long-overdue/ https://www.motherjones.com/politics/2023/04/should-insurers-cover-kids-obesity-drugs-experts-say-its-long-overdue/ Treatments are largely out of reach for communities that need them most. Tue, 25 Apr 2023 04:00:00 Z https://beatrix.yale.edu/news/create https://beatrix.yale.edu/news/create Strong sales of obesity-diabetes drugs known as GLP-1s could affect insurance companies’ financial results. Mon, 17 Apr 2023 04:00:00 Z https://medicine.yale.edu/y-weight/news-article/ysm-announces-creation-of-obesity-research-center/ https://medicine.yale.edu/y-weight/news-article/ysm-announces-creation-of-obesity-research-center/ Yale School of Medicine is establishing a new obesity research center to improve the lives of individuals living with obesity through cutting-edge research and novel therapies. Mon, 27 Mar 2023 04:00:00 Z https://www.healthline.com/health-news/obesity-report-predicts-half-the-world-will-be-overweight-by-2035 https://www.healthline.com/health-news/obesity-report-predicts-half-the-world-will-be-overweight-by-2035 Getting quality nutritious foods is vital to a healthier life, according to Wajahat Mehal, MD, PhD, professor of medicine (digestive diseases), but often these are expensive or difficult to obtain. Mon, 06 Mar 2023 04:00:00 Z