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Innovative Research, Practical Results

How our studies are transforming science

Innovative research in a laboratory setting
Photo by Robert A. Lisak

Women’s Health Research at Yale improves medical research and practice in two ways. First, the center ensures the study of women. The center also examines health differences between and among women and men to improve the lives of everyone.

Research highlights from ongoing pilot projects

Why is colon cancer risk different between women and men?

Dr. Caroline Johnson

Dr. Caroline Johnson is investigating the sources of a type of colon cancer that is more common in women and more deadly than a type more often found in men. She is using a new method to investigate the products of hormones and beneficial bacteria in the colon to determine risk and protective factors in colon cancer.

Developing safer, less invasive monitoring for healthy pregnancy

Dr. Michelle Silasi

Dr. Michelle Silasi is testing markers of inflammation to determine the risk for infection and preterm birth. The patient can begin this test herself. This method can offer an easier and less expensive way to collect samples than by taking blood or using a needle to get amniotic fluid, which also presents a risk to pregnant women.

Using technology to break the cycle of intimate partner violence

Dr. Trace Kershaw

Dr. Trace Kershaw is developing a mobile app to improve decision-making for mothers and daughters exposed to violence in the home. The purpose of this project is to reduce high-risk behaviors and future intimate partner violence.

Understanding your brain on drugs

Dr. Kelly Cosgrove

Dr. Kelly Cosgrove is scanning the action of chemicals in the brain in “real time” and connecting these actions with drug addiction. She developed this technique and is now using it for the first time to understand how cannabis works in the brain. And whether there are sex differences in response to cannabis.

Research Highlights from completed pilot projects

Recognizing heart attacks in women

Dr. Erica Spatz

Dr. Erica Spatz developed a better way to describe and group heart attacks that accounts for the different ways they can develop in women. Previous systems that doctors use to identify the source of symptoms can obscure heart disease and its risk. This new system provides a more personalized, precision-based approach to ensure more informed medical decisions and better outcome for women.

First to test a behavioral therapy for girls with autism spectrum disorder

Dr. Pamela Ventola

Dr. Pamela Ventola tested a behavioral treatment for autism spectrum disorder on girls for the first time. She showed how the treatment not only works for girls but shows better results in girls than boys. Now applied in clinical use, this finding allows researchers and behavioral therapists to explore the specific, different needs of girls and boys with autism.

Breakthrough in using antibodies to treat BRCA-deficient cancers

Dr. Peter Glazer

Dr. Peter Glazer discovered that a product of the body’s immune system associated with the disease lupus can penetrate cancer cells. The cancer cells can then become sensitive to radiation and chemotherapy. Dr. Glazer continues to advance this method for treating cancer. He focuses on types of cancer that develop from inherited mutations to the tumor-suppressing BRCA2 gene.

How beneficial bacteria in the body can lead to autoimmune disease

Dr. Martin Kriegel

Dr. Martin Kriegel showed that bacteria in the small intestines can travel to other organs and confuse immune cells into attacking the body. He also found that targeting the bacteria can suppress this autoimmune response. Such findings provide new ways for treating autoimmune conditions, such as lupus, which occur at far greater rates in women.

From head to toe

Sex and gender differences exist in all areas of human health, not just reproductive sciences. We've funded studies in areas including:

  • Addictive Behaviors
  • Autoimmune Disorders
  • Bone Health
  • Cancer
  • Cardiovascular
  • Endocrine
  • Genetics
  • Health Policy
  • Hormones and Menopause
  • Infectious Disease
  • Mental Health
  • Neurobiology
  • Obesity
  • Reproductive Health
  • Trauma
  • Workplace Injuries