2018
The effect of preclinical Alzheimer's disease on age-related changes in intelligence in cognitively normal older adults
Harrington K, Dang C, Lim Y, Ames D, Laws S, Pietrzak R, Rainey-Smith S, Robertson J, Rowe C, Salvado O, Villemagne V, Masters C, Maruff P, Group F. The effect of preclinical Alzheimer's disease on age-related changes in intelligence in cognitively normal older adults. Intelligence 2018, 70: 22-29. DOI: 10.1016/j.intell.2018.07.004.Peer-Reviewed Original ResearchPreclinical Alzheimer's diseaseAge-related declineAlzheimer's diseaseNormal older adultsOlder adultsRisk of progressionClinical disease progressionRapid age-related declinesEarly Alzheimer's diseaseNormal age-related declineAge-related changesEffect of ageAβ groupProspective studyAβ statusDisease progressionSerial assessmentAbnormal amyloidPET neuroimagingLinear regression analysisNormal agingDiseaseIntellectual functionGreater age-related declineLinear mixed models
2015
Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease: A Multicenter, Prospective Cohort Study
Pietrzak RH, Lim YY, Neumeister A, Ames D, Ellis KA, Harrington K, Lautenschlager NT, Restrepo C, Martins RN, Masters CL, Villemagne VL, Rowe CC, Maruff P. Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease: A Multicenter, Prospective Cohort Study. JAMA Psychiatry 2015, 72: 284-291. PMID: 25629787, DOI: 10.1001/jamapsychiatry.2014.2476.Peer-Reviewed Original ResearchConceptsPreclinical Alzheimer's diseaseSubjective memory complaintsElevated anxiety symptomsVerbal memoryExecutive functionGlobal cognitionAnxiety symptomsCognitive declineCognitive changesMemory complaintsAβ statusDepressive symptomsLow anxiety groupComprehensive neuropsychological evaluationHigh anxiety groupRole of anxietyFlorbetapir F 18Visual memoryCognitive domainsVisuospatial abilitiesMild cognitive impairmentNeuropsychological evaluationCognitive functionProspective cohort studyMore rapid decline