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Leigh Goedeke, PhD


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Leigh Goedeke, PhD



Dr. Leigh Goedeke is an Instructor in the Department of Medicine (Endocrinology) at Yale University School of Medicine. With extensive experience in multiple metabolic disease indications, Dr. Goedeke specializes in the interplay between hepatic steatosis, insulin resistance, type 2 diabetes, and cardiovascular disease. During her graduate studies, under the mentorship of Dr. Carlos Fernandez-Hernando, Dr. Goedeke identified and characterized novel genes and miRNAs involved in lipid metabolism using functional genomic screens. As part of her postdoctoral training in the laboratory of Dr. Gerald Shulman, Dr. Goedeke used stable isotope tracer methods to understand how alterations in metabolic fluxes contribute to the pathogenesis of insulin resistance and is currently investigating the therapeutic potential of liver-targeted mitochondrial uncoupling agents to reverse metabolic syndrome.

Dr. Goedeke holds a Ph.D. in Biomedical Sciences from New York University School of Medicine and a B.S. in Biology from Gettysburg College. She has authored over 30 publications, and holds a patent in specialized anti-microRNA oligonucleotides as therapeutic tools for treating dyslipidemias and cardiovascular diseases.

Education & Training

  • Postdoctoral Fellow
    Yale School of Medicine (2019)
  • PhD
    Sackler Institute of Biomedical Sciences, NYU School of Medicine (2015)
  • BS (Hon)
    Gettysburg College, Biology (2009)

Honors & Recognition

AwardAwarding OrganizationDate
Pathway to Independence AwardNIH (NHLBI)2019

Departments & Organizations