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Arya Mani

Professor of Medicine (Cardiology) and of Genetics; Director, Cardiovascular Genetics Program; Director, Cardiovascular Module

Contact Information

Arya Mani, MD, FACC, FAHA

Patient Care Locations

Lab Location

Mailing Address

  • Cardiovascular Medicine

    PO Box 208056, 333 Cedar Street

    New Haven, CT 06520-8056

    United States



My laboratory’s major focus is the identification of genetic causes of major cardiovascular disorders and the elucidation of their pathophysiology. Through collaborative efforts with physicians and scientist across the world we have recruited large populations of patients and families with early onset coronary artery disease and metabolic syndrome and have successfully mapped and identified number of genes for these diseases. An ongoing effort in the laboratory is to understand the function of these genes and how the mutations affect the phenotype, using mouse and zebrafish models.

Having unique access to the genetic study population, we have had the opportunity to carry out clinical studies to investigate the disease mechanisms and have made numerous novel discoveries. We are actively investigating pathways that regulate insulin signaling, glucose metabolism, VLDL and LDL syntheis and clearance and atherosclerosis.

In addition, my laboratory studies the genetic causes of adult congenital heart disease, such as bicuspid aortic valve, atrial fibrillation and patent ductus arteriosus.

Education & Training

  • Fellow
    Yale University School of Medicine (2001)
  • Resident
    Yale-New Haven Hospital (1996)
  • Fellow
    University of Erlangen-Nuernberg (1992)
  • MD
    Johannes-Gutenberg-University of Mainz (1991)


  • The genetic etiology of coronary artery disease
    Mumbai, India 2001
    Identification of genetic causes of premature coronary artery disease in South Asians
  • Genetics of Cardiovascular Diseases
    Isfahan, Iran; Shiraz, Iran; Tehran, Iran 1998
    Study of genetic causes of coronary artery disease and congenital heart defect

Departments & Organizations