Penile Injection Therapy

Penile injection therapy is one treatment option for Erectile Dysfunction (ED). This treatment has been available to men with ED for over 25 years and is FDA-approved, although many patients are not aware of this option.

You may consider penile injection therapy if you have had: 

  • Lack of improvement using oral medications such as Viagra or Cialis
  • Significant side effects to oral medications
  • Contraindications to oral medications such as use of nitroglycerin products for the heart

In our practice, over 70% of men with ED will have a good result with this treatment. The treatment protocol requires a trial injection in the office. The medication is placed directly into the side of the penis with a tiny needle, which is virtually painless. If you have a good response, you will be taught how to self-inject and then will receive a prescription to fill and use at home. You will be offered a compounded medication that may include prostaglandin E1, papaverine, and phentolamine.  These medications have been used to treat this condition for over 25 years and are considered very safe. 

Another way medication can be delivered locally is through a suppository or intraurethral agent. The man (or his partner) inserts the thin applicator a centimeter into the urethra and injects a pellet-sized bead of alprostadil. The medication dissolves and dilates blood vessels in the penis.

- How long until it takes effect? 5 to 15 minutes

- How long does an erection last? 60 minutes