2019
Results of a pilot/phase II study of gamma knife radiosurgery for brain metastases and implications for future prospective clinical trials
Yu J, Singh C, Bindra R, Contessa J, Husain Z, Hansen J, Park H, Roberts K, Bond J, Tien C, Guo F, Colaco R, Housri N, Magnuson W, Mahajan A, Omay S, Chiang V. Results of a pilot/phase II study of gamma knife radiosurgery for brain metastases and implications for future prospective clinical trials. Journal Of Radiation Oncology 2019, 8: 39-46. DOI: 10.1007/s13566-018-0370-7.Peer-Reviewed Original ResearchYale-New Haven HospitalPhase II studyBrain metastasesClinical trialsII studyKnife radiosurgeryLocal controlPre-defined primary endpointWhole-brain radiation treatmentFuture prospective clinical trialsEvaluable brain metastasesSymptomatic radiation necrosisMedian patient ageLocal control ratePhase 2 studyGood local controlProspective clinical trialsNumber of metastasesLarge clinical trialsProportional hazards regressionFuture clinical trialsGamma knife radiosurgeryImportant clinical variablesStandard clinical practiceNew Haven Hospital
2018
A Pilot/Phase II Study of Stereotactic Radiosurgery for Brain Metastases Using Rational Dose Selection
Yu J, Singh C, Bindra R, Contessa J, Husain Z, Hansen J, Park H, Roberts K, Bond J, Tien C, Guo F, Colaco R, Housri N, Magnuson W, Omay B, Chiang V. A Pilot/Phase II Study of Stereotactic Radiosurgery for Brain Metastases Using Rational Dose Selection. International Journal Of Radiation Oncology • Biology • Physics 2018, 102: e372-e373. DOI: 10.1016/j.ijrobp.2018.07.1113.Peer-Reviewed Original Research
2017
Annual Facility Treatment Volume and Patient Survival for Mycosis Fungoides and Sézary Syndrome
Kann B, Park H, Yeboa D, Aneja S, Girardi M, Foss F, Roberts K, Wilson L. Annual Facility Treatment Volume and Patient Survival for Mycosis Fungoides and Sézary Syndrome. International Journal Of Radiation Oncology • Biology • Physics 2017, 99: e430. DOI: 10.1016/j.ijrobp.2017.06.1632.Peer-Reviewed Original ResearchAnnual Facility Treatment Volume and Patient Survival for Mycosis Fungoides and Sézary Syndrome
Kann BH, Park HS, Yeboa DN, Aneja S, Girardi M, Foss FM, Roberts KB, Wilson LD. Annual Facility Treatment Volume and Patient Survival for Mycosis Fungoides and Sézary Syndrome. Clinical Lymphoma Myeloma & Leukemia 2017, 17: 520-526.e2. PMID: 28655598, DOI: 10.1016/j.clml.2017.05.017.Peer-Reviewed Original ResearchConceptsMF/SSOverall survivalSézary syndromeHazard ratioImproved survivalMycosis fungoidesPatient survivalHighest quintileLowest quintileTreatment volumeImproved overall survivalMultivariable Cox regressionNational Cancer DatabaseKaplan-Meier methodAnnual patient volumeNational database analysisLog-rank testContinuous variablesMedian followMultivariable analysisCox regressionOS survivalCancer DatabasePatientsPatient volume
2016
A Novel Prognostic Index for Ocular Adnexal Lymphoma
Meeks M, Park H, Yu J, Roberts K, Foss F, Wilson L. A Novel Prognostic Index for Ocular Adnexal Lymphoma. Blood 2016, 128: 3597. DOI: 10.1182/blood.v128.22.3597.3597.Peer-Reviewed Original ResearchOcular adnexal lymphomaNovel prognostic indexOverall survivalIndolent histologiesPrognostic indexRelative survivalAdnexal lymphomaGroup IIGroup IGroup I. Group IEnd Results (SEER) databaseSuperior overall survivalCohort of patientsProportional hazards analysisKaplan-Meier estimatesLacrimal gland tumorsHeterogeneous patient populationLarge national databaseAggressive histologyDistant diseaseConjunctival tumorsHazard ratioPrognostic factorsRare malignancyIndependent predictorsPostoperative Radiotherapy Patterns of Care and Survival Implications for Medulloblastoma in Young Children
Kann BH, Park HS, Lester-Coll NH, Yeboa DN, Benitez V, Khan AJ, Bindra RS, Marks AM, Roberts KB. Postoperative Radiotherapy Patterns of Care and Survival Implications for Medulloblastoma in Young Children. JAMA Oncology 2016, 2: 1574-1581. PMID: 27491009, DOI: 10.1001/jamaoncol.2016.2547.Peer-Reviewed Original ResearchConceptsPostoperative radiotherapyOverall survivalMultivariable logistic regressionNational Cancer Data BaseLogistic regressionAdjuvant chemotherapy strategyLow facility volumeNational treatment patternsMultivariable Cox regressionLong-term morbidityYear of diagnosisDay of surgeryKaplan-Meier analysisNational database analysisPoor overall survivalLog-rank testYoung childrenAge 3Adjuvant chemotherapyRadiotherapy patternsRadiotherapy utilizationWorse survivalDistant metastasisMultivariable analysisTreatment patternsAdjuvant Radiation Therapy Patterns and Survival Implications for Medulloblastoma in Young Children
Kann B, Park H, Lester-Coll N, Yeboa D, Benitez V, Bindra R, Khan A, Marks A, Roberts K. Adjuvant Radiation Therapy Patterns and Survival Implications for Medulloblastoma in Young Children. International Journal Of Radiation Oncology • Biology • Physics 2016, 96: s230-s231. DOI: 10.1016/j.ijrobp.2016.06.573.Peer-Reviewed Original ResearchAddition of Chemotherapy to Adjuvant Radiation Therapy is Associated With Improved Overall Survival in Adult Medulloblastoma
Kann B, Lester-Coll N, Park H, Yeboa D, Bindra R, Becker K, Baehring J, Roberts K. Addition of Chemotherapy to Adjuvant Radiation Therapy is Associated With Improved Overall Survival in Adult Medulloblastoma. International Journal Of Radiation Oncology • Biology • Physics 2016, 96: s27-s28. DOI: 10.1016/j.ijrobp.2016.06.080.Peer-Reviewed Original ResearchAdjuvant chemotherapy and overall survival in adult medulloblastoma
Kann BH, Lester-Coll NH, Park HS, Yeboa DN, Kelly JR, Baehring JM, Becker KP, Yu JB, Bindra RS, Roberts KB. Adjuvant chemotherapy and overall survival in adult medulloblastoma. Neuro-Oncology 2016, 19: 259-269. PMID: 27540083, PMCID: PMC5464064, DOI: 10.1093/neuonc/now150.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCerebellar NeoplasmsChemoradiotherapy, AdjuvantChemotherapy, AdjuvantCraniospinal IrradiationFemaleFollow-Up StudiesHumansMaleMedulloblastomaMiddle AgedNeoplasm StagingPrognosisRadiotherapy, AdjuvantSurvival RateYoung AdultConceptsGy craniospinal irradiationCraniospinal irradiationOverall survivalM0 patientsAdjuvant chemotherapyAdult MBMultivariable Cox proportional hazard modelingHigh-dose craniospinal irradiationNational Cancer Data BaseCox proportional hazard modelingSuperior overall survivalPlanned subgroup analysisMultivariable logistic regressionNational database analysisLog-rank testProportional hazard modelingPediatric medulloblastoma patientsCSI dosesPostoperative chemotherapySurgical resectionSurvival impactYear OSMultivariable analysisSubgroup analysisRisk factorsMB-38ADJUVANT RADIOTHERAPY PATTERNS OF CARE AND SURVIVAL IMPLICATIONS FOR MEDULLOBLASTOMA IN YOUNG CHILDREN
Kann B, Park H, Lester-Coll N, Yeboa D, Benitez V, Bindra R, Khan A, Marks A, Roberts K. MB-38ADJUVANT RADIOTHERAPY PATTERNS OF CARE AND SURVIVAL IMPLICATIONS FOR MEDULLOBLASTOMA IN YOUNG CHILDREN. Neuro-Oncology 2016, 18: iii105-iii105. PMCID: PMC4903595, DOI: 10.1093/neuonc/now076.36.Peer-Reviewed Original ResearchThe effect of microscopic margin status on survival in adult retroperitoneal soft tissue sarcomas
Stahl JM, Corso CD, Park HS, An Y, Rutter CE, Han D, Roberts KB. The effect of microscopic margin status on survival in adult retroperitoneal soft tissue sarcomas. European Journal Of Surgical Oncology 2016, 43: 168-174. PMID: 27335080, DOI: 10.1016/j.ejso.2016.05.031.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasOverall survivalR1 resectionR0 resectionMargin statusNational Cancer Data BaseRetroperitoneal soft tissue sarcomaCox proportional hazards regressionPropensity scoreMultivariable logistic regression modelMedian overall survivalMicroscopic margin statusPre-operative RTReceipt of RTUnderwent R0 resectionSuperior overall survivalSmaller tumor sizeLow tumor gradeProportional hazards regressionLog-rank testRetroperitoneal soft tissueLogistic regression modelsLiposarcoma histologyR1 patientsRadiotherapy receipt
2015
Pediatric Brainstem Glioma Survival After Definitive Radiation Therapy With or Without Concurrent Chemotherapy: A Nationwide Comparison
Park H, Yeboa D, Lester-Coll N, Corso C, Mancini B, Bindra R, Roberts K, Yu J, Rutter C. Pediatric Brainstem Glioma Survival After Definitive Radiation Therapy With or Without Concurrent Chemotherapy: A Nationwide Comparison. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e504-e505. DOI: 10.1016/j.ijrobp.2015.07.1836.Peer-Reviewed Original ResearchThe Effect of Margin Status and Radiation Therapy on Survival in Adult Retroperitoneal Soft Tissue Sarcomas
Stahl J, Corso C, An Y, Aneja S, Rutter C, Park H, Mancini B, Yeboa D, Lester-Coll N, Han D, Roberts K. The Effect of Margin Status and Radiation Therapy on Survival in Adult Retroperitoneal Soft Tissue Sarcomas. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e638. DOI: 10.1016/j.ijrobp.2015.07.2175.Peer-Reviewed Original Research
2012
Skull Base Chordoma and Chondrosarcoma: An Update of National Radiation Therapy Patterns and Survival Outcomes in the Modern Era
Park H, Roberts K, Yu J. Skull Base Chordoma and Chondrosarcoma: An Update of National Radiation Therapy Patterns and Survival Outcomes in the Modern Era. International Journal Of Radiation Oncology • Biology • Physics 2012, 84: s286-s287. DOI: 10.1016/j.ijrobp.2012.07.748.Peer-Reviewed Original Research
2011
Survival outcomes in atypical teratoid rhabdoid tumor for patients undergoing radiotherapy in a Surveillance, Epidemiology, and End Results analysis
Buscariollo DL, Park HS, Roberts KB, Yu JB. Survival outcomes in atypical teratoid rhabdoid tumor for patients undergoing radiotherapy in a Surveillance, Epidemiology, and End Results analysis. Cancer 2011, 118: 4212-4219. PMID: 22213196, DOI: 10.1002/cncr.27373.Peer-Reviewed Original ResearchConceptsAtypical teratoid rhabdoid tumorMedian overall survivalOverall survivalRT useLandmark analysisRhabdoid tumorRare central nervous system malignanciesNational Cancer Institute's SurveillanceCentral nervous system malignanciesCox proportional hazards modelRole of radiotherapyEnd Results (SEER) databaseEnd Results analysisSignificant survival benefitProspective clinical trialsGross total resectionPatients ages 4Nervous system malignanciesImmortal time biasProportional hazards modelLong-term survivorshipAdjuvant radiotherapyInitial radiotherapyPrimary endpointInitial management