2023
Case Report: MR-LINAC-guided adaptive radiotherapy for gastric cancer
Song Y, Zhang Y, Wang H, Zhao M, Guan F, Li Z, Yue J. Case Report: MR-LINAC-guided adaptive radiotherapy for gastric cancer. Frontiers In Oncology 2023, 13: 1159197. PMID: 37746250, PMCID: PMC10514477, DOI: 10.3389/fonc.2023.1159197.Peer-Reviewed Original ResearchGastric cancerUpper abdomenGastric cancer patientsCourse of treatmentGastric cancer biopsiesDaily MR imageAdaptive radiotherapyMR-linacAdaptive treatment plansCT simulation imagesBlack stoolCancer patientsCase reportGastroscopy resultsInoperable tumorsPancreatic cancerImage-guided radiotherapyPatientsCancer biopsiesClinical experienceRadiotherapyTreatment planApparent causeCancerStomach
2020
Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns
Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Scientific Reports 2020, 10: 3199. PMID: 32081928, PMCID: PMC7035246, DOI: 10.1038/s41598-020-60246-5.Peer-Reviewed Original ResearchConceptsIntensity-modulated proton therapyLow-energy beamsIntensity modulation patternCurrent treatment planProton therapyBiological effectsDelivery strategiesTarget doseTherapeutic indexTreatment planHigh-energy beamsEffective doseEnhanced biological effectClinical potentialTherapyCancer cellsDoseBragg peak
2019
Potential for Improvements in Robustness and Optimality of Intensity-Modulated Proton Therapy for Lung Cancer with 4-Dimensional Robust Optimization
Ge S, Wang X, Liao Z, Zhang L, Sahoo N, Yang J, Guan F, Mohan R. Potential for Improvements in Robustness and Optimality of Intensity-Modulated Proton Therapy for Lung Cancer with 4-Dimensional Robust Optimization. Cancers 2019, 11: 35. PMID: 30609652, PMCID: PMC6356681, DOI: 10.3390/cancers11010035.Peer-Reviewed Original ResearchLung cancer patientsIntensity-modulated proton therapyCancer patientsIMPT dose distributionsClinical target volume coverageNormal tissue dose distributionsTarget volume coveragePlanning target volumeTarget dose coverageConventional planning target volumeRespiratory motionDose distributionDifferent tumor sizesTarget dose distributionProton therapyTumor sizeLung cancerDose coverageTreatment planIMPT plansTarget volumeNormal tissuesVolume coverageRespiratory phasesPatients
2017
Radiobiological issues in proton therapy
Mohan R, Peeler CR, Guan F, Bronk L, Cao W, Grosshans DR. Radiobiological issues in proton therapy. Acta Oncologica 2017, 56: 1367-1373. PMID: 28826292, PMCID: PMC5842809, DOI: 10.1080/0284186x.2017.1348621.Peer-Reviewed Original ResearchConceptsClinical practiceClinical evidenceProton therapyProton relative biological effectivenessClear clinical evidenceCurrent clinical practiceRelative biological effectivenessIntensity-modulated proton therapyMore patientsTherapeutic ratioUnforeseen toxicityTreatment planTherapyVariable relative biological effectivenessEffective dose distributionRadiation dosePatientsDoseCell typesEstimation of doseDose distributionParticle therapyRadiobiological issuesRBE variabilityEvidence