2023
Case Report: MR-LINAC-guided adaptive radiotherapy for gastric cancer
Song Y, Zhang Y, Wang H, Zhao M, Guan F, Li Z, Yue J. Case Report: MR-LINAC-guided adaptive radiotherapy for gastric cancer. Frontiers In Oncology 2023, 13: 1159197. PMID: 37746250, PMCID: PMC10514477, DOI: 10.3389/fonc.2023.1159197.Peer-Reviewed Original ResearchGastric cancerUpper abdomenGastric cancer patientsCourse of treatmentGastric cancer biopsiesDaily MR imageAdaptive radiotherapyMR-linacAdaptive treatment plansCT simulation imagesBlack stoolCancer patientsCase reportGastroscopy resultsInoperable tumorsPancreatic cancerImage-guided radiotherapyPatientsCancer biopsiesClinical experienceRadiotherapyTreatment planApparent causeCancerStomachPO83 Utilization of a Virtual Clinical Trial to Characterize Sensitivity of the Linear-Quadratic Model
Tien C, Draeger E, Guan F, Carlson D, Chen Z. PO83 Utilization of a Virtual Clinical Trial to Characterize Sensitivity of the Linear-Quadratic Model. Brachytherapy 2023, 22: s110. DOI: 10.1016/j.brachy.2023.06.184.Peer-Reviewed Original ResearchTumor control probabilityClinical trialsLinear-quadratic modelNumber of patientsPatient cohort sizeTCP curvesRadiobiological parametersVirtual clinical trialsGy-1Cohort sizeRange of dosesPatient outcomesReference cohortPatientsHeterogeneous cohortVirtual patientsNew trialsRadiobiological parameter valuesClonogenic populationPatient ordersControl probabilityGyInput model parametersTrialsCohort
2019
Potential for Improvements in Robustness and Optimality of Intensity-Modulated Proton Therapy for Lung Cancer with 4-Dimensional Robust Optimization
Ge S, Wang X, Liao Z, Zhang L, Sahoo N, Yang J, Guan F, Mohan R. Potential for Improvements in Robustness and Optimality of Intensity-Modulated Proton Therapy for Lung Cancer with 4-Dimensional Robust Optimization. Cancers 2019, 11: 35. PMID: 30609652, PMCID: PMC6356681, DOI: 10.3390/cancers11010035.Peer-Reviewed Original ResearchLung cancer patientsIntensity-modulated proton therapyCancer patientsIMPT dose distributionsClinical target volume coverageNormal tissue dose distributionsTarget volume coveragePlanning target volumeTarget dose coverageConventional planning target volumeRespiratory motionDose distributionDifferent tumor sizesTarget dose distributionProton therapyTumor sizeLung cancerDose coverageTreatment planIMPT plansTarget volumeNormal tissuesVolume coverageRespiratory phasesPatients
2017
Radiobiological issues in proton therapy
Mohan R, Peeler CR, Guan F, Bronk L, Cao W, Grosshans DR. Radiobiological issues in proton therapy. Acta Oncologica 2017, 56: 1367-1373. PMID: 28826292, PMCID: PMC5842809, DOI: 10.1080/0284186x.2017.1348621.Peer-Reviewed Original ResearchConceptsClinical practiceClinical evidenceProton therapyProton relative biological effectivenessClear clinical evidenceCurrent clinical practiceRelative biological effectivenessIntensity-modulated proton therapyMore patientsTherapeutic ratioUnforeseen toxicityTreatment planTherapyVariable relative biological effectivenessEffective dose distributionRadiation dosePatientsDoseCell typesEstimation of doseDose distributionParticle therapyRadiobiological issuesRBE variabilityEvidence