2023
Evaluating bone marrow dosimetry with the addition of bone marrow structures to the medical internal radiation dose phantom
Ferrone K, Willis C, Guan F, Ma J, Peterson L, Kry S. Evaluating bone marrow dosimetry with the addition of bone marrow structures to the medical internal radiation dose phantom. Precision Radiation Oncology 2023, 7: 27-35. DOI: 10.1002/pro6.1189.Peer-Reviewed Original ResearchBone marrow doseBone marrowBone marrow structureMarrow doseMedical Internal Radiation Dose (MIRD) methodMarrow structureRadiation-induced cancerRadiation exposure scenariosBone marrow dosimetryAverage doseDoseSoft tissueMarrowMarrow dosimetryRadiation doseDose methodExposure scenariosDose estimation
2020
Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns
Ma D, Bronk L, Kerr M, Sobieski M, Chen M, Geng C, Yiu J, Wang X, Sahoo N, Cao W, Zhang X, Stephan C, Mohan R, Grosshans DR, Guan F. Exploring the advantages of intensity-modulated proton therapy: experimental validation of biological effects using two different beam intensity-modulation patterns. Scientific Reports 2020, 10: 3199. PMID: 32081928, PMCID: PMC7035246, DOI: 10.1038/s41598-020-60246-5.Peer-Reviewed Original ResearchConceptsIntensity-modulated proton therapyLow-energy beamsIntensity modulation patternCurrent treatment planProton therapyBiological effectsDelivery strategiesTarget doseTherapeutic indexTreatment planHigh-energy beamsEffective doseEnhanced biological effectClinical potentialTherapyCancer cellsDoseBragg peak
2017
Radiobiological issues in proton therapy
Mohan R, Peeler CR, Guan F, Bronk L, Cao W, Grosshans DR. Radiobiological issues in proton therapy. Acta Oncologica 2017, 56: 1367-1373. PMID: 28826292, PMCID: PMC5842809, DOI: 10.1080/0284186x.2017.1348621.Peer-Reviewed Original ResearchConceptsClinical practiceClinical evidenceProton therapyProton relative biological effectivenessClear clinical evidenceCurrent clinical practiceRelative biological effectivenessIntensity-modulated proton therapyMore patientsTherapeutic ratioUnforeseen toxicityTreatment planTherapyVariable relative biological effectivenessEffective dose distributionRadiation dosePatientsDoseCell typesEstimation of doseDose distributionParticle therapyRadiobiological issuesRBE variabilityEvidence