2024
Incorporating boron distribution variations in microdosimetric kinetic model-based relative biological effectiveness calculations for boron neutron capture therapy
Li M, Geng C, Han Y, Guan F, Liu Y, Shu D, Tang X. Incorporating boron distribution variations in microdosimetric kinetic model-based relative biological effectiveness calculations for boron neutron capture therapy. Radiation Protection Dosimetry 2024, ncae158. PMID: 39010755, DOI: 10.1093/rpd/ncae158.Peer-Reviewed Original ResearchBiological effects of boron neutron capture therapyCompound biological effectivenessBoron neutron capture therapyCBE valuesNeutron capture therapyBoron distributionRelative biological effectiveness calculationsEnergy spectra of particlesLineal energy spectraSpectrum of particlesEffectiveness of boron neutron capture therapyNucleus radiusBoronMKM modelSurviving fractionRadiusCalculationsDistribution variationBiological effectsImpact of setup errors on the robustness of linac‐based single‐isocenter coplanar and non‐coplanar VMAT plans for multiple brain metastases
Sun X, Guan F, Yun Q, Jennings M, Biggs S, Wang Z, Wang W, Zhang T, Shi M, Zhao L. Impact of setup errors on the robustness of linac‐based single‐isocenter coplanar and non‐coplanar VMAT plans for multiple brain metastases. Journal Of Applied Clinical Medical Physics 2024, 25: e14317. PMID: 38439583, PMCID: PMC11244668, DOI: 10.1002/acm2.14317.Peer-Reviewed Original ResearchNon-coplanar plansPlanning target volumeGross tumor volumePatient setup errorsPlan evaluation metricsSetup errorsMultiple brain metastasesImpact of setup errorsNon-coplanar VMAT plansDose delivery accuracyGamma passing ratesRobust treatment plansModified plansSingle-isocenterVMAT plansGamma analysisRotation errorBrain metastasesDose coverageLinac-basedTreatment planningDelivery accuracyTarget volumePrescribed doseNon-coplanarMulti-omics approaches for biomarker discovery in predicting the response of esophageal cancer to neoadjuvant therapy: A multidimensional perspective
Yang Z, Guan F, Bronk L, Zhao L. Multi-omics approaches for biomarker discovery in predicting the response of esophageal cancer to neoadjuvant therapy: A multidimensional perspective. Pharmacology & Therapeutics 2024, 254: 108591. PMID: 38286161, DOI: 10.1016/j.pharmthera.2024.108591.Peer-Reviewed Original ResearchConceptsPathological complete responseNeoadjuvant chemoradiotherapyEsophageal cancerLocally advanced esophageal cancerPathological complete response patientsAdvanced esophageal cancerStandard treatment strategyPredicting treatment responsePredicting nCRT responseMulti-omics dataMulti-omicsComplete responseNeoadjuvant therapyChemoradiation responseNCRT responsePredictive biomarkersSurvival outcomesActive surveillanceTreatment responsePlanned surgeryEC patientsTreatment strategiesMulti-omics approachImproved biomarkersOrgan preservationEditorial: Advances in the biological effects of ionizing radiation
Guan F, Zhao L, Bronk J, Maletic-Savatic M, Grosshans D, Carlson D. Editorial: Advances in the biological effects of ionizing radiation. Frontiers In Oncology 2024, 13: 1352771. PMID: 38234403, PMCID: PMC10793655, DOI: 10.3389/fonc.2023.1352771.Peer-Reviewed Original Research
2023
Editorial: Innovations, advances, and challenges in precision radiation oncology physics
Guan F, Bronk L, Yue J, Mohan R, Chen Z. Editorial: Innovations, advances, and challenges in precision radiation oncology physics. Precision Radiation Oncology 2023, 7: 222-224. DOI: 10.1002/pro6.1216.Peer-Reviewed Original ResearchCase Report: MR-LINAC-guided adaptive radiotherapy for gastric cancer
Song Y, Zhang Y, Wang H, Zhao M, Guan F, Li Z, Yue J. Case Report: MR-LINAC-guided adaptive radiotherapy for gastric cancer. Frontiers In Oncology 2023, 13: 1159197. PMID: 37746250, PMCID: PMC10514477, DOI: 10.3389/fonc.2023.1159197.Peer-Reviewed Original ResearchGastric cancerUpper abdomenGastric cancer patientsCourse of treatmentGastric cancer biopsiesDaily MR imageAdaptive radiotherapyMR-linacAdaptive treatment plansCT simulation imagesBlack stoolCancer patientsCase reportGastroscopy resultsInoperable tumorsPancreatic cancerImage-guided radiotherapyPatientsCancer biopsiesClinical experienceRadiotherapyTreatment planApparent causeCancerStomachPO61 Can Current Monotherapy High-Dose-Rate Prostate Brachytherapy Prescriptions Overcome Intrafractional DNA Damage Repair and 192Ir Source Decay?
Guan F, Draeger E, Carlson D, Chen Z, Tien C. PO61 Can Current Monotherapy High-Dose-Rate Prostate Brachytherapy Prescriptions Overcome Intrafractional DNA Damage Repair and 192Ir Source Decay? Brachytherapy 2023, 22: s97-s98. DOI: 10.1016/j.brachy.2023.06.162.Peer-Reviewed Original ResearchPO83 Utilization of a Virtual Clinical Trial to Characterize Sensitivity of the Linear-Quadratic Model
Tien C, Draeger E, Guan F, Carlson D, Chen Z. PO83 Utilization of a Virtual Clinical Trial to Characterize Sensitivity of the Linear-Quadratic Model. Brachytherapy 2023, 22: s110. DOI: 10.1016/j.brachy.2023.06.184.Peer-Reviewed Original ResearchTumor control probabilityClinical trialsLinear-quadratic modelNumber of patientsPatient cohort sizeTCP curvesRadiobiological parametersVirtual clinical trialsGy-1Cohort sizeRange of dosesPatient outcomesReference cohortPatientsHeterogeneous cohortVirtual patientsNew trialsRadiobiological parameter valuesClonogenic populationPatient ordersControl probabilityGyInput model parametersTrialsCohortCharacterization of GafchromicTM EBT4 film with clinical kV/MV photons and MeV electrons
Guan F, Chen H, Draeger E, Li Y, Aydin R, Tien C, Chen Z. Characterization of GafchromicTM EBT4 film with clinical kV/MV photons and MeV electrons. Precision Radiation Oncology 2023, 7: 84-91. DOI: 10.1002/pro6.1204.Peer-Reviewed Original ResearchX-ray beamMeV electron beamMV photon beamElectron beamMV photonsBeam energyMeV electronsPhoton beamsEnergy dependenceKilovoltage x-ray beamsMinimal energy dependenceClinical photonPhotonsBeamRadiation typesMeVElectronsDependence experimentsFilmsDose-response dependenceResponse dependenceDependenceEnergyNoise ratioEBT3Evaluating bone marrow dosimetry with the addition of bone marrow structures to the medical internal radiation dose phantom
Ferrone K, Willis C, Guan F, Ma J, Peterson L, Kry S. Evaluating bone marrow dosimetry with the addition of bone marrow structures to the medical internal radiation dose phantom. Precision Radiation Oncology 2023, 7: 27-35. DOI: 10.1002/pro6.1189.Peer-Reviewed Original ResearchBone marrow doseBone marrowBone marrow structureMarrow doseMedical Internal Radiation Dose (MIRD) methodMarrow structureRadiation-induced cancerRadiation exposure scenariosBone marrow dosimetryAverage doseDoseSoft tissueMarrowMarrow dosimetryRadiation doseDose methodExposure scenariosDose estimationDosimetric response of Gafchromic™ EBT‐XD film to therapeutic protons
Guan F, Wang X, Yang M, Draeger E, Han D, Iga K, Guo F, Perles L, Li Y, Sahoo N, Mohan R, Chen Z. Dosimetric response of Gafchromic™ EBT‐XD film to therapeutic protons. Precision Radiation Oncology 2023, 7: 15-26. PMID: 37868341, PMCID: PMC10586355, DOI: 10.1002/pro6.1187.Peer-Reviewed Original ResearchLinear energy transferEBT-XD filmsTherapeutic protonsFilm calibrationProton linear energy transferUltra-high Dose Rate FLASH RadiotherapyDynamic dose rangeMV photon beamDose-averaged LET valuesDose rate dependenceProton beamlineProton beamPhoton beamsFLASH beamSpot scanning proton beamsDosimetric responseLET dependenceFLASH radiotherapyHigh-dose applicationFilm responseLET valuesEnergy transferBeamProtonsGafchromicA Review of Magnetic Shielding Technology for Space Radiation
Ferrone K, Willis C, Guan F, Ma J, Peterson L, Kry S. A Review of Magnetic Shielding Technology for Space Radiation. Radiation 2023, 3: 46-57. DOI: 10.3390/radiation3010005.Peer-Reviewed Original ResearchAdding the X‐ray Bragg reflection physical process in crystal to the Geant4 Monte Carlo simulation toolkit, part I: reflection from a crystal slab
Guan F, Asai M, Bartkoski D, Kleckner M, Harel Z, Salehpour M. Adding the X‐ray Bragg reflection physical process in crystal to the Geant4 Monte Carlo simulation toolkit, part I: reflection from a crystal slab. Precision Radiation Oncology 2023, 7: 59-66. DOI: 10.1002/pro6.1188.Peer-Reviewed Original ResearchMonte Carlo simulation toolkitCrystal slabX-ray diffractionPhysical processesGeant4 Monte Carlo simulation toolkitX-ray photonsIncident photon beamSimulation toolkitParticle physicsBragg diffractionPhysics processesPhoton trackingWave naturePhoton beamsBragg angleBragg reflectionsLaue diffractionBragg's lawModel classGeneral formPhotonsSpecial caseGeant4Specular reflectionDiffractionCase Report: MR-LINAC-guided adaptive radiotherapy for gastric cancer
Song Y, Zhang Y, Wang H, Zhao M, Guan F, Li Z, Yue J. Case Report: MR-LINAC-Guided Adaptive Radiotherapy for Gastric cancer. Frontiers in Oncology.;13:1159197.Peer-Reviewed Case Reports and Technical Notes
2022
Impact of dose calculation accuracy on inverse linear energy transfer optimization for intensity‐modulated proton therapy
Chen M, Cao W, Yepes P, Guan F, Poenisch F, Xu C, Chen J, Li Y, Vazquez I, Yang M, Zhu X, Zhang X. Impact of dose calculation accuracy on inverse linear energy transfer optimization for intensity‐modulated proton therapy. Precision Radiation Oncology 2022, 7: 36-44. DOI: 10.1002/pro6.1179.Peer-Reviewed Original ResearchIntensity-modulated proton therapyDose calculation accuracyMore beamsCalculation accuracyMC algorithmMonte Carlo algorithmDifferent dose calculation algorithmsTransfer optimizationProstate cancer patientsIntensity-modulated proton therapy (IMPT) plansProton therapyClinical target volumeNumber of beamsPencil beam algorithmDose calculation algorithmPlan robustnessDose calculation engineCarlo algorithmEnergy transfer optimizationFinal dose calculationInverse treatmentDose differenceCancer patientsProton therapy plansDose constraintsEnhanced Radiation-Sparing Effects of Ultra-High Dose Rate Proton Radiation (FLASH-RT) in a Human Induced Pluripotent Stem Cell-Derived Cerebral Organoid Model
Bronk J, Bronk L, Singh S, Guan F, Wang X, Zhu X, Schueler E, Jiang D, Mohan R, Koong A, Lang F, Grosshans D. Enhanced Radiation-Sparing Effects of Ultra-High Dose Rate Proton Radiation (FLASH-RT) in a Human Induced Pluripotent Stem Cell-Derived Cerebral Organoid Model. International Journal Of Radiation Oncology • Biology • Physics 2022, 114: s66. DOI: 10.1016/j.ijrobp.2022.07.456.Peer-Reviewed Original ResearchGlioma stem-like cellsNeural progenitor cellsCerebral organoid modelFLASH-RTMature neuronsRadiation-related side effectsProgenitor cellsSpecific cell populationsOrganoid modelsPotential protective effectPreclinical animal modelsCell populationsAggressive brain tumorConventional dose ratesLactate dehydrogenase releaseDelivery of radiationTumor cell proliferationHuman brain tissueStem-like cellsChronic neuroinflammationTumor responseAntitumoral effectivenessProtective effectBrain tumorsSide effectsPyMedPhys: A community effort to develop an open,Python-based standard library for medical physics applications
Biggs S, Jennings M, Swerdloff S, Chlap P, Lane D, Rembish J, McAloney J, King P, Ayala R, Guan F, Lambri N, Crewson C, Sobolewski M. PyMedPhys: A community effort to develop an open,Python-based standard library for medical physics applications. The Journal Of Open Source Software 2022, 7: 4555. DOI: 10.21105/joss.04555.Peer-Reviewed Original ResearchOptimization of FLASH proton beams using a track‐repeating algorithm
Wang Q, Titt U, Mohan R, Guan F, Zhao Y, Yang M, Yepes P. Optimization of FLASH proton beams using a track‐repeating algorithm. Medical Physics 2022, 49: 6684-6698. PMID: 35900902, DOI: 10.1002/mp.15849.Peer-Reviewed Original ResearchLooking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel
Bokhari R, Beheshti A, Blutt S, Bowles D, Brenner D, Britton R, Bronk L, Cao X, Chatterjee A, Clay D, Courtney C, Fox D, Gaber M, Gerecht S, Grabham P, Grosshans D, Guan F, Jezuit E, Kirsch D, Liu Z, Maletic-Savatic M, Miller K, Montague R, Nagpal P, Osenberg S, Parkitny L, Pierce N, Porada C, Rosenberg S, Sargunas P, Sharma S, Spangler J, Tavakol D, Thomas D, Vunjak-Novakovic G, Wang C, Whitcomb L, Young D, Donoviel D. Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel. Life Sciences In Space Research 2022, 35: 105-112. PMID: 36336356, DOI: 10.1016/j.lssr.2022.08.003.Peer-Reviewed Original ResearchRoadmap: helium ion therapy
Mairani A, Mein S, Blakely E, Debus J, Durante M, Ferrari A, Fuchs H, Georg D, Grosshans DR, Guan F, Haberer T, Harrabi S, Horst F, Inaniwa T, Karger CP, Mohan R, Paganetti H, Parodi K, Sala P, Schuy C, Tessonnier T, Titt U, Weber U. Roadmap: helium ion therapy. Physics In Medicine And Biology 2022, 67: 15tr02. PMID: 35395649, DOI: 10.1088/1361-6560/ac65d3.Peer-Reviewed Original ResearchConceptsHelium ion beamHeavy ion therapyIon beam therapyHelium ionsIon beamIon therapyRelative biological effectivenessHeavy ion beamsLawrence Berkeley National LaboratoryCarbon ion beamsHelium ion therapyDifferent particle speciesBerkeley National LaboratoryClinical proton beamsCarbon ion therapyLinear energy transferHigh relative biological effectivenessSharp lateral penumbraHigh penetration depthLateral scatteringNeon ionsBeam therapyProton beamParticle speciesTerms of physics