SIMCAP (Surgery in Metastatic Carcinoma of Prostate): Phase 2.5 Multi-Institution Randomized Prospective Clinical Trial Evaluating the Impact of Cytoreductive Radical Prostatectomy Combined With Best Systemic Therapy on Oncologic and Quality of Life Outcomes in Men With Newly Diagnosed Metastatic Prostate Cancer
Volunteers
Health Professionals
What is the purpose of this trial?
This randomized phase II trial studies how well surgical removal of the prostate and antiandrogen therapy with or without docetaxel work in treating men with newly diagnosed prostate cancer that has spread to other places in the body. Androgens can cause the growth of prostate cancer cells. Antiandrogen therapy may lessen the amount of androgens made by the body. Drugs used in chemotherapy, such as docetaxel work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Surgery, antiandrogen therapy and docetaxel may work better in treating participants with prostate cancer.
- Trial withYale Cancer Center
- Ages18 years and older
- GenderMale only
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Principal Investigator
Sub-Investigators
- Agatha Hecht
- Alessia Donadio, MD
- Andrea Brennan
- Armand Russo, MD
- Ashita Talsania, MRCP, MBBS
- Benjamin Newton, MD
- Beverly Drucker, MD, PhD
- Brooke Chaves
- D. Barry Boyd, MD, MS
- Daniel P. Petrylak, MD
- David Witt, MD
- Elan Gorshein, DO, JD, MPH
- Emily Collier, MD
- Emily Kopas, APRN, OCN
- Hari Deshpande, MD
- Harold Tara Jr, MD
- Jade Vanacore
- Jane Kanowitz, MD
- Jason Haldas, MD
- Jeremy Kortmansky, MD
- Johanna LaSala, MD
- John Glendening
- Joseph Kim, MD
- Joseph Renzulli, MD, FACS
- Justin Persico, MD
- Karishma Mehra, MBBS
- Katherine Harvey, MD, MPH
- Kathleen Fenn, MD
- Kelsey Martin, MD
- Kert Sabbath, MD, FACP
- Kristen Hoxie
- Lynn Mastrianni
- M. Sung Lee, MD
- Madeline Santiago
- Matthew Austin, MD
- Michael Cohenuram, MD
- Michael Hurwitz, MD, PhD
- Michael S. Leapman, MD, MHS
- Michelle Laspino
- Neal Fischbach, MD
- Pawan Karanam, MD
- Preston C. Sprenkle, MD
- Robert Legare, MD
- Sara Anastasio, RN
- Sarah Carlson
- Stephanie Paine, APRN
- Stephen Lattanzi, MD
- Syed Ali
- Vanna Dest
- Vidya Kesavan
- Virginia Syombathy
- Wajih Kidwai, MD, FACP
- Xuanthao Thi Nguyen
- Zia Rahman, MD
- Last Updated08/15/2023
- Study HIC#2000031290