Thomas L McCarthy PhD

Research Scientist in Pathology

Departments & Organizations

Pathology: Madri Lab | Yale Core Center for Musculoskeletal Disorders | Surgery

Research Interests

Hormonal and molecular control of IGF-I expression and TGF-b function in osteoblasts; osteoblast gene expression, including steroid hormone interactions with signaling pathways that control gene expression; native and synthetic sex steroid metabolism by osteoblasts, including synthesis of a selective estrogen receptor modulator by aging osteoblast cultures; interactions of protein kinases and steroid hormones as they affect gene expression more...


  • Ph.D., University of Rochester, 1980

Selected Publications

  • McCarthy, T. L., M. E. Clough, C. M. Gundberg, M. Centrella (2008) Expression of an estrogen receptor agonist in differentiating osteoblast cultures. Proc. Natl. Acad. Sci. USA 105:7022-7027.
  • McCarthy, T. L., R. B. Hochberg, D. C. Labaree, M. Centrella (2007) 3-ketosteroid reductase activity and expression by fetal rat osteoblasts. J. Biol. Chem. 282:34003-34012.
  • McCarthy, T. L., T. Pham, B. I. Knoll, M. Centrella (2007) Prostaglandin E2 increases TGF-b type III receptor expression through CAAT enhancer binding protein d in osteoblasts. Mol. Endocrinol. 21:2713-2724.



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