Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle Cell Proliferation and Arterial Restenosis by Regulating AKT and PKA-CREB Signaling
Cai Y, Wang XL, Lu J, Lin X, Dong J, Guzman RJ. Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle Cell Proliferation and Arterial Restenosis by Regulating AKT and PKA-CREB Signaling. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41: 2431-2451. PMID: 34196217, PMCID: PMC8411910, DOI: 10.1161/atvbaha.121.316219.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementCell ProliferationCells, CulturedConstriction, PathologicCREB-Binding ProteinCyclic AMP-Dependent Protein KinasesCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27Disease Models, AnimalFemaleFemoral ArteryMaleMice, Inbred C57BLMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaPhenylurea CompoundsProtein Kinase InhibitorsProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktPyrimidinesRats, Sprague-DawleySignal TransductionTranscription FactorsVascular System InjuriesConceptsSmooth muscle cellsArterial restenosisNeointima formationSMC proliferationSMC migrationSIK inhibitionVascular smooth muscle cell proliferationPeripheral arterial diseaseSmooth muscle cell proliferationVascular smooth muscle cellsAortic smooth muscle cellsPotential therapeutic strategyMuscle cell proliferation