2024
The Italian experience on liver transplantation for unresectable peri-hilar cholangiocarcinoma: a national survey and future perspectives
Gringeri E, Furlanetto A, Billato I, Cescon M, De Carlis L, Mazzaferro V, Romagnoli R, De Simone P, Vivarelli M, Di Benedetto F, Ravaioli M, Lauterio A, Sposito C, Patrono D, Ghinolfi D, Moccheggiani F, Di Sandro S, D’Amico F, Lanari J, Gambato M, Trapani S, Bergamo F, Cardillo M, Burra P, Cillo U. The Italian experience on liver transplantation for unresectable peri-hilar cholangiocarcinoma: a national survey and future perspectives. Updates In Surgery 2024, 1-9. PMID: 39210194, DOI: 10.1007/s13304-024-01889-1.Peer-Reviewed Original ResearchAdvocating for a “shift-to-left” in transplant oncology: left grafts, RAPID and dual graft
Cillo U, Furlanetto A, Gringeri E, Bertacco A, Marchini A, Rosso E, Bassi D, D’Amico F, Line P. Advocating for a “shift-to-left” in transplant oncology: left grafts, RAPID and dual graft. Updates In Surgery 2024, 1-14. PMID: 39120859, DOI: 10.1007/s13304-024-01919-y.Peer-Reviewed Original ResearchLiving donor liver transplantationRisk of small-for-size syndromeSmall-for-size syndromeDual-graft living donor liver transplantationHigh-volume transplant centerDonor liver transplantationDonor-recipient matchingShortage of graftsLeft-lobeLiver transplantationRight-lobeOncological indicationsTransplant oncologyDonor hepatectomyDual graftsTransplant centersHigh riskLeft graftGraftFull-left/Full-right Liver Splitting With Middle Hepatic Vein and Caval Partition During Dual Hypothermic Oxygenated Machine Perfusion
Cillo U, Lauterio A, Furlanetto A, Canitano N, Polacco M, Buscemi V, De Carlis R, Boetto R, D’Amico F, Bassi D, De Carlis L, Gringeri E. Full-left/Full-right Liver Splitting With Middle Hepatic Vein and Caval Partition During Dual Hypothermic Oxygenated Machine Perfusion. Transplantation 2024, 108: 1417-1421. PMID: 38755751, DOI: 10.1097/tp.0000000000005039.Peer-Reviewed Original ResearchMiddle hepatic veinHypothermic oxygenated machine perfusionOxygenated machine perfusionHepatic veinVena cavaMachine perfusionEffects of ischemia-reperfusion injuryLiver splittingDual hypothermic oxygenated machine perfusionIschemia-reperfusion injuryProlonged cold ischemiaSplit liver transplantationEx situ splittingPediatric patientsVenous reconstructionParenchymal transectionAdult patientsLiver transplantationHepatocellular carcinomaVenous congestionRight graftCold ischemiaVenous outflowProlonged ischemiaImprove outcomesRecurrence and tumor-related death after resection of hepatocellular carcinoma in patients with metabolic syndrome
Berardi G, Cucchetti A, Sposito C, Ratti F, Nebbia M, D’Souza D, Pascual F, Dogeas E, Tohme S, Vitale A, D’Amico F, Alessandris R, Panetta V, Simonelli I, Colasanti M, Russolillo N, Moro A, Fiorentini G, Serenari M, Rotellar F, Zimitti G, Famularo S, Ivanics T, Donando F, Hoffman D, Onkendi E, Essaji Y, Giuliani T, Ben S, Caula C, Rompianesi G, Chopra A, Abu Hilal M, Sapisochin G, Torzilli G, Corvera C, Alseidi A, Helton S, Troisi R, Simo K, Conrad C, Cescon M, Cleary S, Kwon D, Ferrero A, Ettorre G, Cillo U, Geller D, Cherqui D, Serrano P, Ferrone C, Aldrighetti L, Kingham T, Mazzaferro V. Recurrence and tumor-related death after resection of hepatocellular carcinoma in patients with metabolic syndrome. JHEP Reports 2024, 6: 101075. PMID: 38961853, PMCID: PMC11220535, DOI: 10.1016/j.jhepr.2024.101075.Peer-Reviewed Original ResearchLong-term outcomes of liver resectionRecurrence-free survivalTime of recurrenceCancer-specific survivalTumor-related factorsDevelopment of hepatocellular carcinomaHepatocellular carcinomaMetabolic syndromeLong-term survivalRisk factorsOverall survivalImpact survivalResection of hepatocellular carcinomaOutcomes of liver resectionCurative intent approachPost-recurrence survivalPredictors of recurrenceHazard of recurrenceTreatment of recurrenceRisk of recurrenceTumor-related deathLong-term outcomesDesigning future trialsAssociated with deathMedian OSLIVING DONOR LIVER DONATION IN THE ONCOLOGICAL FIELD: WHAT’S NEW
Gringeri E, Furlanetto A, Lanari J, Marchini A, Dolcet A, Bassi D, Boetto R, D’Amico F, Bertacco A, Perin L, Nieddu E, Ballo M, Rosso E, Nardi C, Canitano N, Cillo U. LIVING DONOR LIVER DONATION IN THE ONCOLOGICAL FIELD: WHAT’S NEW. European Journal Of Transplantation 2024, 2: 22-28. DOI: 10.57603/ejt-434.Peer-Reviewed Original ResearchWhat Is the Role of Minimally Invasive Liver Surgery in Treating Patients with Hepatocellular Carcinoma on Cirrhosis?
Vitale A, Angelico R, Sensi B, Lai Q, Kauffmann E, Scalera I, Serenari M, Ginesini M, Romano P, Furlanetto A, D’Amico F. What Is the Role of Minimally Invasive Liver Surgery in Treating Patients with Hepatocellular Carcinoma on Cirrhosis? Cancers 2024, 16: 966. PMID: 38473327, PMCID: PMC10930835, DOI: 10.3390/cancers16050966.Peer-Reviewed Original ResearchMinimally invasive liver surgeryOpen surgeryLiver surgerySignificant cardiovascular riskTrans-arterial approachResection outcomesLaparoscopic ablationResected casesLiver transplantationTreated patientsHepatocellular carcinomaEfficacious therapyCardiovascular riskSurgeryPatientsNarrative reviewTreatment hierarchyCurative techniqueHCCResectionCarcinomaCirrhosisTransplantationTherapyEx situ liver resection for intrahepatic cholangiocarcinoma: survival analysis and comparison to systemic chemotherapy
Nieddu E, Billato I, Peluso C, Furlanetto A, Lazzari S, D'Amico F, Cillo U, Gringeri E. Ex situ liver resection for intrahepatic cholangiocarcinoma: survival analysis and comparison to systemic chemotherapy. Digestive And Liver Disease 2024, 56: s42. DOI: 10.1016/j.dld.2024.01.067.Peer-Reviewed Original ResearchProgression-free survivalCA19-9 levelsEx situ liver resectionOverall survivalIntrahepatic cholangiocarcinomaEx situ surgeryStage of diseasePerformance statusSystemic chemotherapySurgical resectionLiver resectionLiver functionHigh-volume hepatobiliary centersLower stage of diseaseMedian progression-free survivalTreated with surgical resectionEvaluate long-term outcomesSurvival analysisEx situ resectionNon-parametric log-rank testTreated with chemotherapyLog-rank testLiver function testsCox regression analysisLong-term outcomesLiver resection versus radiofrequency ablation or trans-arterial chemoembolization for early-stage (BCLC A) oligo-nodular hepatocellular carcinoma: meta-analysis
Romano P, Busti M, Billato I, D’Amico F, Marchegiani G, Pelizzaro F, Vitale A, Cillo U. Liver resection versus radiofrequency ablation or trans-arterial chemoembolization for early-stage (BCLC A) oligo-nodular hepatocellular carcinoma: meta-analysis. BJS Open 2024, 8: zrad158. PMID: 38323881, PMCID: PMC10848305, DOI: 10.1093/bjsopen/zrad158.Peer-Reviewed Original ResearchConceptsBarcelona Clinic Liver CancerTrans-arterial chemoembolizationDisease-free survivalBarcelona Clinic Liver Cancer-A patientsBenefits of LRLiver resectionRadiofrequency ablationHepatocellular carcinomaOS benefitOverall survivalA patientsBarcelona Clinic Liver Cancer ABarcelona Clinic Liver Cancer stageDisease-free survival benefitRisk ratioOutcomes of LRMeta-analysisComparative cohort studyCase-control studyChina Biological Medicine DatabaseHCC patientsCohort studyPrimary outcomeNewcastle-OttawaQuality of studiesThe crucial role of abdominal procurement surgery as a prerequisite for pancreatoduodenectomy: an overview
Bassi D, Caregari S, D'Amico F, Marchegiani G, Cillo U. The crucial role of abdominal procurement surgery as a prerequisite for pancreatoduodenectomy: an overview. Hepato Pancreato Biliary 2024, 26: s501. DOI: 10.1016/j.hpb.2024.03.1059.Peer-Reviewed Original ResearchUpfront surgery vs. upfront chemotherapy for multiple, centimetric, resectable colorectal liver metastasis: a single institution study
D'Amico F, Alessandris R, Castigliego R, Della Libera M, Bassi D, Marchini A, Lanari J, Gringeri E, Cillo U. Upfront surgery vs. upfront chemotherapy for multiple, centimetric, resectable colorectal liver metastasis: a single institution study. Hepato Pancreato Biliary 2024, 26: s180-s181. DOI: 10.1016/j.hpb.2024.03.337.Peer-Reviewed Original ResearchAblation and resection in the surgical treatment of liver metastases from colorectal cancer: analysis of procedure-related recurrence patterns
D'Amico F, Alessandris R, Della Libera M, Castigliego R, Bassi D, Marchini A, Lanari J, Gringeri E, Cillo U. Ablation and resection in the surgical treatment of liver metastases from colorectal cancer: analysis of procedure-related recurrence patterns. Hepato Pancreato Biliary 2024, 26: s181. DOI: 10.1016/j.hpb.2024.03.338.Peer-Reviewed Original Research
2023
Anatomic Versus Nonanatomic Resection
Cillo U, Marchini A, D’Amico F, Gringeri E. Anatomic Versus Nonanatomic Resection. 2023, 55-58. DOI: 10.1007/978-3-031-35295-9_6.Peer-Reviewed Original ResearchTarget lesionsNonanatomical liver resectionColorectal liver metastasesInvasive liver surgeryViable liver tissueLiver pedicleNonanatomic resectionAnatomical resectionOncological outcomesLiver metastasesLiver resectionNonanatomical resectionLiver surgeryResectionLiver tissueAnatomical regionsLesionsSurgeryMetastasisHCCPedicleParenchyma
2022
L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL
Finotti M, Barahona M, Maina R, Lysyy T, Agarwal R, Schmitt P, Caturegli G, Di Renzo C, Anselmo A, Mulligan D, Geibel J, D'Amico F. L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL. Transplantation Reports 2022, 7: 100096. DOI: 10.1016/j.tpr.2022.100096.Peer-Reviewed Original ResearchIschemic injuryIntestinal segmentsIschemic damageIntraluminal perfusionNitric oxide-arginine pathwayMale Sprague-Dawley ratsN-nitroarginine methyl esterSprague-Dawley ratsEx vivo perfusion modelVivo perfusion modelNon-ischemic conditionsSmall intestinal segmentsFITC-inulinExtraluminal sideL-NAMEReperfusion injuryProtective effectL-arginineSmall intestinePerfusion modelInjuryIntestinal regionsFluid secretionReduced susceptibilityPerfusion
2012
Use of N‐acetylcysteine during liver procurement: A prospective randomized controlled study
D'Amico F, Vitale A, Piovan D, Bertacco A, Morales R, Frigo A, Bassi D, Bonsignore P, Gringeri E, Valmasoni M, Garbo G, Lodo E, D'Amico FE, Scopelliti M, Carraro A, Gambato M, Brolese A, Zanus G, Neri D, Cillo U. Use of N‐acetylcysteine during liver procurement: A prospective randomized controlled study. Liver Transplantation 2012, 19: 135-144. PMID: 22859317, DOI: 10.1002/lt.23527.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAdolescentAdultAgedAntioxidantsChi-Square DistributionFemaleGraft SurvivalHumansInfusions, IntravenousItalyKaplan-Meier EstimateLiver TransplantationMaleMiddle AgedPortal VeinPrimary Graft DysfunctionProportional Hazards ModelsProspective StudiesSingle-Blind MethodTime FactorsTissue and Organ HarvestingTreatment OutcomeYoung AdultConceptsGraft survivalLiver transplantationNAC groupLiver procurementN-acetylcysteineControl groupSuboptimal graftsEffect of NACNAC protocolIschemia/reperfusion damageFirst liver transplantationEarly graft functionGraft survival ratesChronic liver diseaseSingle-blinded procedureGraft functionLT outcomesPostoperative complicationsPrimary endpointCox analysisNAC infusionRandomized studyLiver diseaseAdult candidatesPrimary dysfunction
2010
FIRST REPORT OF COMPLETE REMISSION, AFTER VISCERAL KAPOSI'I SARCOMA, IN AN ISOLATED INTESTINAL TRANSPLANT RECIPIENT; INCLUDING A SYSTEMATIC LITERATURE REVIEW
D'Amico F, Fuxman C, Vitale A, Nachman F, Bitetti L, Fauda M, Cabanne A, Gondolesi G. FIRST REPORT OF COMPLETE REMISSION, AFTER VISCERAL KAPOSI'I SARCOMA, IN AN ISOLATED INTESTINAL TRANSPLANT RECIPIENT; INCLUDING A SYSTEMATIC LITERATURE REVIEW. Transplantation 2010, 90: 1027. DOI: 10.1097/00007890-201007272-02017.Peer-Reviewed Original Research
2009
842 ACTIVATED SRC FAMILY KINASE LYN AS SIGNALING MOLECULE FOR MITOCHONDRIA IN EARLY LIVER REGENERATION
Gringeri E, Carraro A, Tibladi E, D'Amico F, Mancon M, Toninello A, Pagano M, Brunati A, Cillo U. 842 ACTIVATED SRC FAMILY KINASE LYN AS SIGNALING MOLECULE FOR MITOCHONDRIA IN EARLY LIVER REGENERATION. Journal Of Hepatology 2009, 50: s307. DOI: 10.1016/s0168-8278(09)60844-8.Peer-Reviewed Original Research
2007
Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures
Brunati A, Tibaldi E, Carraro A, Gringeri E, D’Amico F, Toninello A, Massimino M, Pagano M, Nalesso G, Cillo U. Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures. Biochimica Et Biophysica Acta 2007, 1783: 347-359. PMID: 18157950, DOI: 10.1016/j.bbamcr.2007.11.008.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factorHepatic stellate cellsTyrosine phosphorylation of PDGF receptorsSignaling pathwayPlatelet-derived growth factor stimulationCross-talkPlatelet-derived growth factor signaling pathwaysPhosphorylation of PDGF receptorS1P signalingStimulation of chemotaxisPlasma membranePhosphorylated formSphingosine-1-phosphateEffect of FTY720Activation of hepatic stellate cellsReceptor-independent wayFTY720 phosphorylationDevelopment of hepatic fibrosisS1P signaling pathwayPDGF receptorsCell typesCell proliferationPhosphorylationAntifibrotic actionMechanism of actionA New Experimental Model of Isolated Perfused Pig Liver to Support Acute Hepatic Failure
Carraro A, Gringeri E, Calabrese F, Violi P, Brolese A, Zanus G, Boccagni P, Valente M, Bassi D, D’Amico F, D’Amico D, Cillo U. A New Experimental Model of Isolated Perfused Pig Liver to Support Acute Hepatic Failure. Transplantation Proceedings 2007, 39: 2028-2030. PMID: 17692683, DOI: 10.1016/j.transproceed.2007.05.070.Peer-Reviewed Original ResearchConceptsPerfused liver modelIsolated porcine liverLiver transplantationLiver failureAwaiting transplantationOrgan procurement ratesHepatic functionEffective treatmentEx vivo perfused liver modelPortal bloodHemodynamic homeostasisIsolated liverPerfused pig liverLiverLiver supportRecipient pigsTransplantationPatientsIsolated perfused pig liverLiver modelProcurement ratesMetabolic capacity
2005
Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatocellular carcinoma
Cillo U, Vitale A, Navaglia F, Basso D, Montin U, Bassanello M, D'Amico F, Ciarleglio F, Brolese A, Zanus G, De Pascale V, Plebani M, D'Amico D. Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatocellular carcinoma. World Journal Of Gastroenterology 2005, 11: 6920-6925. PMID: 16437593, PMCID: PMC4717031, DOI: 10.3748/wjg.v11.i44.6920.Peer-Reviewed Original ResearchConceptsTumor gradeHepatocellular carcinomaRadical therapyAFP mRNASurgical therapyMRNA statusPrognostic evaluation of HCC patientsAssessment of tumor gradePrognostic evaluation of patientsDiagnosis of hepatocellular carcinomaNodule sizeDetermination of tumor gradeEvaluation of HCC patientsPreoperative tumor gradeMedian follow-upPercutaneous ablative proceduresTumor-related variablesSignificant survival predictorsPotential prognostic roleCohort of patientsEvaluation of patientsSignificant prognosticatorsPrognostic rolePercutaneous biopsyPerformance status
2003
Thermal homeostasis and liver transplantation.
D'Amico D, Vitale A, Cillo U, Boccagni P, Brolese A, Zanus G, Bassanello M, Montin U, Gringeri E, D'Amico F, Ciarleglio F, Cappuzzo G, Carraro A. Thermal homeostasis and liver transplantation. Acta BioMedica 2003, 74 Suppl 2: 30-3. PMID: 15055030.Peer-Reviewed Original ResearchConceptsGraft ischemia-reperfusion injuryGraft function recoveryPostoperative graft functionIschemia-reperfusion injuryInfluence of hypothermiaIntraoperative heat lossGraft functionLiver transplantationSevere hypothermiaCoagulation systemNormothermic oxygenated perfusionFunctional recoveryExtracorporeal circuitDonor poolAngiogenic mechanismsHypothermiaActive warmingOxygenated perfusionThermal homeostasisClinical researchGraftCardiovascular activityLiverDeleterious effectsHomeostasis