2021
Brief report: Cannabis and opioid use disorder among heart failure admissions, 2008–2018
Chouairi F, Mullan CW, Ravindra N, Clark KAA, Jaffe EM, Bhinder J, Fuery M, Guha A, Ahmad T, Desai NR. Brief report: Cannabis and opioid use disorder among heart failure admissions, 2008–2018. PLOS ONE 2021, 16: e0255514. PMID: 34591847, PMCID: PMC8483306, DOI: 10.1371/journal.pone.0255514.Peer-Reviewed Original ResearchVariants of the aortic arch in adult general population and their association with thoracic aortic aneurysm disease
Yousef S, Singh S, Alkukhun A, Alturkmani B, Mori M, Chen J, Mullan CW, Brooks CW, Assi R, Gruber PJ, Cortopassi I, Geirsson A, Vallabhajosyula P. Variants of the aortic arch in adult general population and their association with thoracic aortic aneurysm disease. Journal Of Cardiac Surgery 2021, 36: 2348-2354. PMID: 33855754, DOI: 10.1111/jocs.15563.Peer-Reviewed Original ResearchConceptsAortic arch anomaliesArch anomaliesAneurysm diseaseBovine archAberrant right subclavian arteryAdult populationThoracic aortic aneurysm diseasePrevalence of TAAsRight-sided archRight subclavian arteryCharacteristics of patientsIndependent risk factorAortic valve pathologyAdult general populationGeneral adult populationAortic aneurysm diseaseLogistic regression analysisSingle health systemFisher's exact testOlder adult populationBinary logistic regressionThoracic aortopathiesSubclavian arteryCommon diagnosisThoracic aneurysm
2020
Combined Valve Operations in the Aortic and Mitral Positions With or Without Added Tricuspid Valve Repair
Faggion Vinholo T, Mori M, Mahmood SUB, Mullan CW, Weininger G, Yousef S, Geirsson A. Combined Valve Operations in the Aortic and Mitral Positions With or Without Added Tricuspid Valve Repair. Seminars In Thoracic And Cardiovascular Surgery 2020, 32: 665-672. PMID: 32060011, DOI: 10.1053/j.semtcvs.2020.02.010.Peer-Reviewed Original ResearchConceptsDouble valve surgeryPerioperative adverse eventsTricuspid valve repairTricuspid regurgitationValve surgeryAdverse eventsValve repairMitral valveMitral positionValve functionTriple valve surgeryMid-term survivalLimited clinical evidenceSingle-institution seriesSubpopulation of patientsTricuspid valve functionMitral valve diseaseValve operationsLogistic regression modelsSignificant additional riskMultivalve surgeryPostoperative echocardiogramsPatient comorbiditiesMultivariable analysisClinical evidence
2015
Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial
Lindesmith LC, Ferris MT, Mullan CW, Ferreira J, Debbink K, Swanstrom J, Richardson C, Goodwin RR, Baehner F, Mendelman PM, Bargatze RF, Baric RS. Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial. PLOS Medicine 2015, 12: e1001807. PMID: 25803642, PMCID: PMC4371888, DOI: 10.1371/journal.pmed.1001807.Peer-Reviewed Original ResearchConceptsTime of vaccinationAb responsesVLP vaccineHuman volunteersProtective immunityAb titersCandidate vaccinesEffective NoV vaccinesPhase I ClinicalCross-strain protectionSurrogate neutralization assayBlockade antibodiesAb blockadeNoV infectionBlockade assayAcute gastroenteritisImmune responseNeutralization assaysNoV vaccinesVaccine componentsPredominant GIIMultiple epitopesVaccinationPrevious exposure historyAntigenic drift