2020
Local immunosuppression in vascularized composite allotransplantation (VCA): A systematic review
Safi AF, Kauke M, Nelms L, Palmer WJ, Tchiloemba B, Kollar B, Haug V, Pomahač B. Local immunosuppression in vascularized composite allotransplantation (VCA): A systematic review. Journal Of Plastic Reconstructive & Aesthetic Surgery 2020, 74: 327-335. PMID: 33229219, DOI: 10.1016/j.bjps.2020.10.003.Peer-Reviewed Original ResearchConceptsLocal immunosuppressionSystematic reviewAllograft survivalComposite allotransplantationAllograft survival dataCell-based therapy strategiesImproved allograft survivalMain immunosuppressive agentMeta-Analyses (PRISMA) guidelinesPreclinical animal studiesPreferred Reporting ItemsMalignant side effectsImmunosuppressive agentsPreclinical dataSignificant prolongationRat modelHuman trialsExclusion criteriaImmunosuppressionSide effectsAnimal studiesReporting ItemsPubMed databaseSystemic toxicityTherapy strategiesIndications for and Outcomes of Endoscopic Sinus Surgery and Other Rhinologic Surgery After Facial Transplant
Haug V, Yamasaki A, Fullerton Z, Maxfield A, Pomahac B, Bergmark R, Annino D. Indications for and Outcomes of Endoscopic Sinus Surgery and Other Rhinologic Surgery After Facial Transplant. JAMA Otolaryngology - Head & Neck Surgery 2020, 146: 669-671. PMID: 32525516, PMCID: PMC7290693, DOI: 10.1001/jamaoto.2020.0774.Peer-Reviewed Original Research
2018
Face transplantation—current status and future developments
Tasigiorgos S, Kollar B, Krezdorn N, Bueno E, Tullius S, Pomahac B. Face transplantation—current status and future developments. Transplant International 2018, 31: 677-688. PMID: 29421860, DOI: 10.1111/tri.13130.Peer-Reviewed Original Research
2017
Seasonal Variability Precipitating Hand Transplant Rejection?
Lopdrup R, Turk M, Win T, Marty F, Molway D, Tullius S, Pomahac B, Talbot S. Seasonal Variability Precipitating Hand Transplant Rejection? Transplantation 2017, 101: e313. PMID: 28930103, DOI: 10.1097/tp.0000000000001877.Peer-Reviewed Original ResearchThe Effects of Lip-Closure Exercise on Lip Strength and Function Following Full Facial Transplantation: A Case Report
Perry B, Richburg B, Pomahac B, Bueno E, Green J. The Effects of Lip-Closure Exercise on Lip Strength and Function Following Full Facial Transplantation: A Case Report. American Journal Of Speech-Language Pathology 2017, 26: 682-686. PMID: 28654949, DOI: 10.1044/2017_ajslp-16-0101.Peer-Reviewed Original ResearchConceptsLip strengthFacial transplantationPatient-reported outcomesFull facial transplantationRange of motionStrength training exercisesSevere facial disfigurementPreliminary findingsExercise programAdditional researchCase reportOutcome measuresClinical measuresSingle patientMotor impairmentTransplantationClinical casesPatientsFacial disfigurementExerciseEfficacyNew optionsSpeech intelligibilityExpressionSwallowingOutcomes of Solid Organ Transplants After Simultaneous Solid Organ and Vascularized Composite Allograft Procurements
Aycart M, Alhefzi M, Sharma G, Krezdorn N, Bueno E, Talbot S, Carty M, Tullius S, Pomahac B. Outcomes of Solid Organ Transplants After Simultaneous Solid Organ and Vascularized Composite Allograft Procurements. Transplantation 2017, 101: 1381-1386. PMID: 27140518, PMCID: PMC6347371, DOI: 10.1097/tp.0000000000001262.Peer-Reviewed Original ResearchMeSH KeywordsAdultComposite Tissue AllograftsFacial TransplantationFemaleGraft SurvivalHumansMaleMiddle AgedOperative TimeOrgan TransplantationPostoperative ComplicationsRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTissue and Organ HarvestingTissue DonorsTreatment OutcomeUnited StatesYoung AdultConceptsGraft survival ratesSolid organsSurvival rateLiver recipientsTransplant recipientsAllograft procurementSolid organ allograftsSolid organ transplantsBrain-dead donorsLong-term outcomesShort-term resultsHeart recipientsIntraoperative parametersDonor surgeryOperative durationOrgan allograftsPostoperative outcomesScientific RegistryTransplantation outcomesPopulation of subjectsCase reportOperative characteristicsUnknown causeNationwide analysisOrgan transplantsFirst Lower Two-Thirds Osteomyocutaneous Facial Allograft Perfused by a Unilateral Facial Artery
Fischer S, Lee T, Krezdorn N, Alhefzi M, Kueckelhaus M, Bueno E, Pomahac B. First Lower Two-Thirds Osteomyocutaneous Facial Allograft Perfused by a Unilateral Facial Artery. Plastic & Reconstructive Surgery 2017, 139: 1175e-1183e. PMID: 28445377, DOI: 10.1097/prs.0000000000003288.Peer-Reviewed Original ResearchConceptsFacial arteryFacial allograftImmunosuppressive therapyRejection episodesAirway volumeVenous outflowCLINICAL QUESTION/LEVELDual immunosuppressive therapyFacial allotransplantationTwo-thirdsMaintenance therapyMycophenolate mofetilSteroid pulseArtery anastomosisSurgical durationFacial functionTracheostomy tubeContralateral sideVascular anastomosisSubmental arteryTransplantationArteryAllograftsVascularization patternFacial form
2016
Long-Term Effects of the Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis After Silicone Implants
Fischer S, Diehm Y, Henzler T, Berger M, Kolbenschlag J, Latz A, Bueno E, Hirche C, Kneser U, Pomahac B. Long-Term Effects of the Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis After Silicone Implants. Aesthetic Plastic Surgery 2016, 41: 211-220. PMID: 28008464, DOI: 10.1007/s00266-016-0724-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiopsy, NeedleBreast ImplantationBreast ImplantsClostridium histolyticumDisease Models, AnimalFemaleFibrosisHumansImmunohistochemistryImplant Capsular ContractureInjections, IntralesionalMagnetic Resonance ImagingMicrobial CollagenasePregnancyRandom AllocationRatsRats, Inbred LewReal-Time Polymerase Chain ReactionReference ValuesSilicone GelsTreatment OutcomeUltrasonography, DopplerConceptsMagnetic resonance imagingBacterium Clostridium histolyticumSilicone implantsCapsular fibrosisCollagenase injectionTreatment groupsSkin perforationFrequent long-term complicationMethodsForty-eight ratsMiniature silicone implantsLong-term complicationsClostridium histolyticumViable treatment optionLevel of evidenceHigh-resolution ultrasoundCapsule thicknessInjection of collagenaseExpression levelsDays post injectionLevel AssignedThis journalLong-term effectivenessBackgroundCapsular contractureAnti-fibrotic genesTreatment optionsImplant pocketA Retrospective Analysis of Secondary Revisions after Face Transplantation
Aycart M, Alhefzi M, Kueckelhaus M, Krezdorn N, Bueno E, Caterson E, Pribaz J, Pomahac B. A Retrospective Analysis of Secondary Revisions after Face Transplantation. Plastic & Reconstructive Surgery 2016, 138: 690e-701e. PMID: 27673540, DOI: 10.1097/prs.0000000000002605.Peer-Reviewed Original ResearchConceptsFree tissue transferSecondary revisionFace transplantationMedical recordsRetrospective analysisTissue transferCLINICAL QUESTION/LEVELA Retrospective AnalysisDevastating facial injuriesSkin flap lossMedian time intervalAutologous free tissue transferPatients' medical recordsLocal tissue rearrangementAcute rejectionMaintenance immunosuppressionPulse steroidsPostoperative complicationsMajor infectionSuperficial musculoaponeurotic system plicationCertain patientsOperative reportsRevision surgeryFlap lossRevision proceduresThe role of face transplantation in the self-inflicted gunshot wound
Kiwanuka H, Aycart M, Gitlin D, Devine E, Perry B, Win T, Bueno E, Alhefzi M, Krezdorn N, Pomahac B. The role of face transplantation in the self-inflicted gunshot wound. Journal Of Plastic Reconstructive & Aesthetic Surgery 2016, 69: 1636-1647. PMID: 27720683, DOI: 10.1016/j.bjps.2016.08.014.Peer-Reviewed Original ResearchMeSH KeywordsAdultBone TransplantationDecision Making, Computer-AssistedFacial InjuriesFacial TransplantationFemaleHumansMaleMass ScreeningMiddle AgedPatient SatisfactionPlastic Surgery ProceduresPsychological TechniquesRetrospective StudiesSelf-Injurious BehaviorSurgical FlapsTreatment OutcomeUnited StatesWounds, GunshotConceptsSelf-inflicted gunshot woundsFace transplantationGunshot woundsFT recipientsPsychosocial outcomesSubset of patientsPartial face transplantationFree tissue transferLoco-regional flapsSerial debridementConventional reconstructionWomen's HospitalMultidisciplinary evaluationRetrospective analysisAesthetic deficitsNormal restorationSoft tissue repairMental illnessTissue transferReconstructive surgeonPsychosocial componentsSuicidal behaviorScreening processMidfacial defectsRecipientsPatient Recruitment and Referral Patterns in Face Transplantation
Kiwanuka H, Aycart M, Bueno E, Alhefzi M, Krezdorn N, Pomahac B. Patient Recruitment and Referral Patterns in Face Transplantation. Plastic & Reconstructive Surgery 2016, 138: 224-231. PMID: 27348655, DOI: 10.1097/prs.0000000000002268.Peer-Reviewed Original ResearchConceptsReferral patternsPhysician referralPatient recruitmentFace transplantationDemographic characteristicsShort-term resultsClinical trial statusPatient characteristicsTransplantation centersRetrospective reviewAuthors' centerClinical trialsImmediate exclusionAesthetic deficitsPhysician educationAverage ageBurn communityTrial statusProtocol approvalRelationship of characteristicsTransplantationReferralUnited StatesAreas of improvementInjuryA Mobile Extracorporeal Extremity Salvage System for Replantation and Transplantation
Kueckelhaus M, Fischer S, Sisk G, Kiwanuka H, Bueno E, Dermietzel A, Alhefzi M, Aycart M, Diehm Y, Pomahac B. A Mobile Extracorporeal Extremity Salvage System for Replantation and Transplantation. Annals Of Plastic Surgery 2016, 76: 355-360. PMID: 26808757, DOI: 10.1097/sap.0000000000000681.Peer-Reviewed Original ResearchConceptsMuscle damageLimb lossPerfusion deviceDeceased organ donorsIschemic muscle damageBilateral hind limbsPreferred treatmentBilateral limbsMuscle biopsyOrgan donorsTraumatic amputationHealthy limbPerfusion solutionReplantationArterial systemTransplantationHypoxic cellsPerfusate compositionHind limbPorcine limbsLimbSignificant differencesYorkshire pigsSalvage systemSimilar changes
2015
The Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis after Silicone Implants
Fischer S, Hirsch T, Diehm Y, Kiefer J, Bueno E, Kueckelhaus M, Kremer T, Hirche C, Kneser U, Pomahac B. The Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis after Silicone Implants. Plastic & Reconstructive Surgery 2015, 136: 981-989. PMID: 26171751, DOI: 10.1097/prs.0000000000001698.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiopsy, NeedleBreast ImplantsClostridium histolyticumDisease Models, AnimalFemaleFibrosisImmunohistochemistryImplant Capsular ContractureMagnetic Resonance ImagingMicrobial CollagenaseRandom AllocationRatsReal-Time Polymerase Chain ReactionReference ValuesSilicone GelsTreatment OutcomeConceptsBacterium Clostridium histolyticumSilicone implantsSkin perforationFibrotic capsuleMiniature silicone implantsClostridium histolyticumMagnetic resonance imagingInflammatory markersDosage-dependent decreasePolymerase chain reaction analysisCapsular fibrosisSafe clinical applicationCapsular contractureDupuytren's contractureMechanical irritationChain reaction analysisControl groupDrug AdministrationResonance imagingHistologic measurementsU.S. FoodThin capsuleVivo studiesSkin digestionCollagen densityReconstructive Management of Devastating Electrical Injuries to the Face
Janis J, Khansa I, Lehrman C, Orgill D, Pomahac B. Reconstructive Management of Devastating Electrical Injuries to the Face. Plastic & Reconstructive Surgery 2015, 136: 839-847. PMID: 26090762, DOI: 10.1097/prs.0000000000001619.Peer-Reviewed Original ResearchConceptsElectrical injuryFace transplantationCase seriesTrauma centerReconstructive challengeLevel 1 trauma centerCLINICAL QUESTION/LEVELRetrospective case seriesLarge case seriesCare of patientsLife-threatening injuriesComposite tissue allotransplantationSignificant reconstructive challengePotential recipient vesselsReconstructive managementRenal impairmentAntigen sensitizationInitial managementElectrical burnsReconstructive proceduresMicrosurgical reconstructionPatient injuryRecipient vesselsCardiac arrhythmiasTissue allotransplantation
2014
Airway Recovery after Face Transplantation
Fischer S, Wallins J, Bueno E, Kueckelhaus M, Chandawarkar A, Diaz-Siso J, Larson A, Murphy G, Annino D, Caterson E, Pomahac B. Airway Recovery after Face Transplantation. Plastic & Reconstructive Surgery 2014, 134: 946e-954e. PMID: 25415117, DOI: 10.1097/prs.0000000000000752.Peer-Reviewed Original ResearchMeSH KeywordsAirway ObstructionFacial InjuriesFacial TransplantationHumansMaleNasal MucosaTomography, X-Ray ComputedTreatment OutcomeConceptsAirway volumeUpper airwayFace transplantationRespiratory mucosaNasal passagesIncidence of sinusitisUpper airway infectionsUpper airway impairmentSevere facial injuriesQuality of lifeLife-altering consequencesAirway recoveryTracheostomy decannulationChronic coughAirway infectionFunctional airwayAirway impairmentNasal breathingTracheostomy tubeNasal mucosaSurgical correctionTomographic scanWomen's HospitalMucin productionFacial injuriesFacial and Hand Allotransplantation
Pomahac B, Gobble R, Schneeberger S. Facial and Hand Allotransplantation. Cold Spring Harbor Perspectives In Medicine 2014, 4: a015651. PMID: 24478387, PMCID: PMC3935393, DOI: 10.1101/cshperspect.a015651.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationFacial transplantationLong-term immunosuppressionMinimization of immunosuppressionGood functional outcomeTreatment of patientsMultidisciplinary team approachNovel therapeutic optionsSevere facial disfigurementAllograft survivalHand allotransplantationSkin rejectionTherapeutic optionsFunctional outcomeLimb lossComposite allotransplantationSide effectsTeam approachTransplantationSurgical planningFacial disfigurementImmunosuppressionAllotransplantationComplex proceduresPatients
2013
The Case for Lower Extremity Allotransplantation
Carty M, Zuker R, Cavadas P, Pribaz J, Talbot S, Pomahac B. The Case for Lower Extremity Allotransplantation. Plastic & Reconstructive Surgery 2013, 131: 1272-1277. PMID: 23416434, DOI: 10.1097/prs.0b013e31828bd1a5.Peer-Reviewed Original Research
2011
Evolution of indications for facial transplantation
Pomahac B, Diaz-Siso J, Bueno E. Evolution of indications for facial transplantation. Journal Of Plastic Reconstructive & Aesthetic Surgery 2011, 64: 1410-1416. PMID: 21843979, DOI: 10.1016/j.bjps.2011.06.024.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlast InjuriesBurnsFacial InjuriesFacial TransplantationFemaleHumansMaleMiddle AgedPatient SelectionTreatment OutcomeWounds, GunshotConceptsLong-term outcomesFace transplantationUnknown long-term outcomesAbsolute exclusion criteriaInstitutional review board approvalExpansion of indicationsReview board approvalPartial face transplantationFacial transplantationFacial defectsEvolution of indicationsSevere facial defectsFacial functionLifelong immunosuppressionCurrent indicationsExclusion criteriaBoard approvalTransplantationSafe reductionSensory functionPatientsPotential patientsTransplantation studiesImmunosuppressionIndications
2009
Use of a non–cross-linked porcine dermal scaffold in abdominal wall reconstruction
Pomahac B, Aflaki P. Use of a non–cross-linked porcine dermal scaffold in abdominal wall reconstruction. The American Journal Of Surgery 2009, 199: 22-27. PMID: 19427629, DOI: 10.1016/j.amjsurg.2008.12.033.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal WallAdultAgedAged, 80 and overAnimalsBiocompatible MaterialsCohort StudiesCollagenFemaleFollow-Up StudiesHernia, AbdominalHernia, VentralHumansMaleMiddle AgedPlastic Surgery ProceduresRetrospective StudiesSeverity of Illness IndexSurgical Wound DehiscenceSuture TechniquesSwineTensile StrengthTreatment OutcomeWound HealingYoung AdultConceptsAbdominal wall reconstructionSuperficial wound dehiscenceAbdominal wallComplex abdominal wallWall reconstructionWound dehiscencePorcine dermalProsthetic meshRetrospective chart reviewIntra-abdominal catastropheSurgical site infectionLarge incisional herniasGiant ventral herniasComplicated abdominal wallMean followMultiorgan failureAbdominal traumaEmergency surgeryOpen abdomenChart reviewSite infectionAbdominal closureFistula formationWound infectionIncisional hernia
2006
Fourth-Degree Burns to the Lower Extremity with Exposed Tendon and Bone: A Ten-Year Experience
Parrett B, Pomahac B, Demling R, Orgill D. Fourth-Degree Burns to the Lower Extremity with Exposed Tendon and Bone: A Ten-Year Experience. Journal Of Burn Care & Research 2006, 27: 34-39. PMID: 16566535, DOI: 10.1097/01.bcr.0000192265.20514.c5.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAmputation, SurgicalAtmospheric PressureBacteremiaBurn UnitsBurnsCellulitisDebridementFemaleGranulation TissueHumansLength of StayLimb SalvageLower ExtremityMaleMiddle AgedRetrospective StudiesSurgical FlapsTreatment OutcomeUrban Health ServicesVacuumVenous ThrombosisWound HealingConceptsLower extremity burnsLimb salvageBurn sizeMultistage reconstructive proceduresMean hospital stayDeep vein thrombosisMultiple skin graftsSignificant functional impairmentTen-year experienceUrban burn centerFree tissue transferFourth-degree burnsMajority of casesHospital stayVein thrombosisMean ageFillet flapBurn centerFunctional impairmentLower extremitiesSkin graftsExtremity burnsFlap closureReconstructive proceduresLimb amputation