2024
Cellular therapeutics and immunotherapies in wound healing – on the pulse of time?
Huelsboemer L, Knoedler L, Kochen A, Yu C, Hosseini H, Hollmann K, Choi A, Stögner V, Knoedler S, Hsia H, Pomahac B, Kauke-Navarro M. Cellular therapeutics and immunotherapies in wound healing – on the pulse of time? Military Medical Research 2024, 11: 23. PMID: 38637905, PMCID: PMC11025282, DOI: 10.1186/s40779-024-00528-5.Peer-Reviewed Original ResearchConceptsStandard of careChronic wound healing disordersLocal wound irrigationWound healingChronic inflammatory microenvironmentFree flap techniqueWound healing disordersChronic woundsGenetic risk profilesPhysiological wound healingAdequate blood supplySurgical debridementFlap techniqueCellular therapyCurrent therapiesHealing disordersInflammatory microenvironmentWound irrigationNon-healing woundsCellular therapeuticsGeneral anesthesiaFormation of biofilmsWound debridementSkin graftsImmunotherapy
2014
Functional Outcomes of Face Transplantation
Fischer S, Kueckelhaus M, Pauzenberger R, Bueno E, Pomahac B. Functional Outcomes of Face Transplantation. American Journal Of Transplantation 2014, 15: 220-233. PMID: 25359281, DOI: 10.1111/ajt.12956.Peer-Reviewed Original ResearchWound healing in acutely injured fascia
Lau F, Pomahac B. Wound healing in acutely injured fascia. Wound Repair And Regeneration 2014, 22: 14-17. PMID: 24813359, DOI: 10.1111/wrr.12165.Peer-Reviewed Original ResearchConceptsFascial healingIncisional herniaApparent functional deficitsSpecific surgical methodsFascial wound healingPaucity of dataHealing failureAcute injuryFunctional deficitsSurgical methodsSurgical proceduresSuch herniasMedical costsClinical settingHerniaClinical methodsFasciaWound healingHealingUnexpected findingRecent studiesSuch healingFailureCeliotomyPatients
2012
Predictors for Major Wound Complications Following Preoperative Radiotherapy and Surgery for Soft-Tissue Sarcoma of the Extremities and Trunk: Importance of Tumor Proximity to Skin Surface
Baldini E, Lapidus M, Wang Q, Manola J, Orgill D, Pomahac B, Marcus K, Bertagnolli M, Devlin P, George S, Abraham J, Ferrone M, Ready J, Raut C. Predictors for Major Wound Complications Following Preoperative Radiotherapy and Surgery for Soft-Tissue Sarcoma of the Extremities and Trunk: Importance of Tumor Proximity to Skin Surface. Annals Of Surgical Oncology 2012, 20: 1494-1499. PMID: 23242820, DOI: 10.1245/s10434-012-2797-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overDiabetes ComplicationsDisease-Free SurvivalFemaleHumansLower ExtremityMaleMiddle AgedNeoadjuvant TherapyNeoplasm Recurrence, LocalPostoperative ComplicationsRadiotherapy, AdjuvantSarcomaSkinSkin TransplantationSoft Tissue NeoplasmsSurgical FlapsTorsoUpper ExtremityWound HealingYoung AdultConceptsMajor wound complicationsSoft tissue sarcomasSplit-thickness skin graftPreoperative radiotherapyWound complicationsPostoperative radiotherapyMultivariable analysisTumor proximityExact testResultsMedian tumor sizeSimilar local controlOverall survival rateLong-term fibrosisSignificant predictorsFisher's exact testHigh rateNonoperative managementIndependent predictorsRadical resectionTumor sizeSkin surfaceUnivariate analysisSkin graftsComplicationsLocal controlEpidermal Regeneration by Micrograft Transplantation with Immediate 100-Fold Expansion
Hackl F, Bergmann J, Granter S, Koyama T, Kiwanuka E, Zuhaili B, Pomahac B, Caterson E, Junker J, Eriksson E. Epidermal Regeneration by Micrograft Transplantation with Immediate 100-Fold Expansion. Plastic & Reconstructive Surgery 2012, 129: 443e-452e. PMID: 22373992, DOI: 10.1097/prs.0b013e318241289c.Peer-Reviewed Original ResearchConceptsSplit-thickness skin graftSkin graftsDermal sideEarly clinical resultsCorresponding time pointsFull-thickness woundsMicrograft transplantationDiabetic pigsClinical resultsMajor burnsCurrent treatmentSkin micrograftsComplete epithelializationDiabetic woundsWound chambersPercent reepithelializationGraftChronic woundsHealthy pigsTime pointsWound repairWoundsTransplantationMicrograftsEpidermal regeneration
2010
Meshed Skin Grafts Placed Upside Down Can Take If Desiccation Is Prevented
Zuhaili B, Aflaki P, Koyama T, Fossum M, Reish R, Schmidt B, Pomahac B, Eriksson E. Meshed Skin Grafts Placed Upside Down Can Take If Desiccation Is Prevented. Plastic & Reconstructive Surgery 2010, 125: 855-865. PMID: 20195112, PMCID: PMC2848958, DOI: 10.1097/prs.0b013e3181ccdc42.Peer-Reviewed Original ResearchConceptsSkin graftsMeshed graftReepithelialization rateSplit-thickness skin graftMeshed skin graftAutologous split-thickness skin graftWound environmentFull-thickness woundsHistologic specimensAccelerated reepithelializationDay 4GraftHigh contraction rateWound contractionSheet graftsWound healingWoundsYorkshire pigsSignificant differencesSurvivalHealingRegular graftsReepithelializationContraction rateCurrent study
2009
Use of a non–cross-linked porcine dermal scaffold in abdominal wall reconstruction
Pomahac B, Aflaki P. Use of a non–cross-linked porcine dermal scaffold in abdominal wall reconstruction. The American Journal Of Surgery 2009, 199: 22-27. PMID: 19427629, DOI: 10.1016/j.amjsurg.2008.12.033.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal WallAdultAgedAged, 80 and overAnimalsBiocompatible MaterialsCohort StudiesCollagenFemaleFollow-Up StudiesHernia, AbdominalHernia, VentralHumansMaleMiddle AgedPlastic Surgery ProceduresRetrospective StudiesSeverity of Illness IndexSurgical Wound DehiscenceSuture TechniquesSwineTensile StrengthTreatment OutcomeWound HealingYoung AdultConceptsAbdominal wall reconstructionSuperficial wound dehiscenceAbdominal wallComplex abdominal wallWall reconstructionWound dehiscencePorcine dermalProsthetic meshRetrospective chart reviewIntra-abdominal catastropheSurgical site infectionLarge incisional herniasGiant ventral herniasComplicated abdominal wallMean followMultiorgan failureAbdominal traumaEmergency surgeryOpen abdomenChart reviewSite infectionAbdominal closureFistula formationWound infectionIncisional hernia
2007
Safety Evaluation of Topically Applied Amitriptyline in Porcine Full-Thickness Wounds
Pomahac B, Zuhaili B, Kudsi Y, Bleiziffer O, Velander P, Eriksson E, Gerner P. Safety Evaluation of Topically Applied Amitriptyline in Porcine Full-Thickness Wounds. Regional Anesthesia & Pain Medicine 2007, 32: 377-381. PMID: 17961834, DOI: 10.1016/j.rapm.2007.06.003.Peer-Reviewed Original ResearchConceptsFull-thickness woundsPorcine full-thickness woundsSerum levelsWound chambersTopical applicationWound contractionEffects of amitriptylineManagement of painDaily topical applicationHigher serum levelsExcised burn woundsFull-thickness skin biopsiesOvert toxic effectsLevels of amitriptylineTricyclic antidepressant amitriptylineNeuropathic painPain clinicHistopathological findingsNormal salineSkin biopsiesHistological assessmentAntidepressant amitriptylineDay 2Control groupAmitriptyline
2006
Fourth-Degree Burns to the Lower Extremity with Exposed Tendon and Bone: A Ten-Year Experience
Parrett B, Pomahac B, Demling R, Orgill D. Fourth-Degree Burns to the Lower Extremity with Exposed Tendon and Bone: A Ten-Year Experience. Journal Of Burn Care & Research 2006, 27: 34-39. PMID: 16566535, DOI: 10.1097/01.bcr.0000192265.20514.c5.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAmputation, SurgicalAtmospheric PressureBacteremiaBurn UnitsBurnsCellulitisDebridementFemaleGranulation TissueHumansLength of StayLimb SalvageLower ExtremityMaleMiddle AgedRetrospective StudiesSurgical FlapsTreatment OutcomeUrban Health ServicesVacuumVenous ThrombosisWound HealingConceptsLower extremity burnsLimb salvageBurn sizeMultistage reconstructive proceduresMean hospital stayDeep vein thrombosisMultiple skin graftsSignificant functional impairmentTen-year experienceUrban burn centerFree tissue transferFourth-degree burnsMajority of casesHospital stayVein thrombosisMean ageFillet flapBurn centerFunctional impairmentLower extremitiesSkin graftsExtremity burnsFlap closureReconstructive proceduresLimb amputation
2002
Cultured autologous fibroblasts augment epidermal repair1
Svensjo T, Yao F, Pomahac B, Winkler T, Eriksson E. Cultured autologous fibroblasts augment epidermal repair1. Transplantation 2002, 73: 1033-1041. PMID: 11965028, DOI: 10.1097/00007890-200204150-00004.Peer-Reviewed Original ResearchAutologous Skin Transplantation: Comparison of Minced Skin to Other Techniques
Svensjö T, Pomahac B, Yao F, Slama J, Wasif N, Eriksson E. Autologous Skin Transplantation: Comparison of Minced Skin to Other Techniques. Journal Of Surgical Research 2002, 103: 19-29. PMID: 11855913, DOI: 10.1006/jsre.2001.6331.Peer-Reviewed Original Research
2001
Autologous Keratinocyte Suspensions Accelerate Epidermal Wound Healing in Pigs
Svensjö T, Yao F, Pomahac B, Eriksson E. Autologous Keratinocyte Suspensions Accelerate Epidermal Wound Healing in Pigs. Journal Of Surgical Research 2001, 99: 211-221. PMID: 11469889, DOI: 10.1006/jsre.2001.6197.Peer-Reviewed Original Research
2000
Accelerated Healing of Full-Thickness Skin Wounds in a Wet Environment
Svensjö T, Pomahac B, Yao F, Slama J, Eriksson E. Accelerated Healing of Full-Thickness Skin Wounds in a Wet Environment. Plastic & Reconstructive Surgery 2000, 106: 602-612. PMID: 10987467, DOI: 10.1097/00006534-200009010-00012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEpidermal CellsEpidermisEpitheliumGranulation TissueHumiditySkinSwineWound HealingConceptsFull-thickness skin woundsSkin woundsAccelerated healingSaline-treated woundsGranulation tissue formationYoung Yorkshire pigsSecondary intentionTreatment modalitiesWound healing processSkin wound repairGranulation tissueWound healing modelWound contractionStandardized fashionPorcine wound healing modelFast contractionHealing processWound repairWoundsCell layerYorkshire pigsMoist woundSkin repairHealing modelHealing
1998
Dermatan Sulfate Released after Injury Is a Potent Promoter of Fibroblast Growth Factor-2 Function*
Penc S, Pomahac B, Winkler T, Dorschner R, Eriksson E, Herndon M, Gallo R. Dermatan Sulfate Released after Injury Is a Potent Promoter of Fibroblast Growth Factor-2 Function*. Journal Of Biological Chemistry 1998, 273: 28116-28121. PMID: 9774430, DOI: 10.1074/jbc.273.43.28116.Peer-Reviewed Original ResearchConceptsWound fluidDermatan sulfateFactor 2 activityFibroblast growth factor-2Growth factor 2Factor 2 functionHuman wound fluidPotent mediatorSulfated glycosaminoglycan concentrationsSyndecan-1Fibroblast growth factor‐2 activityWound repairWound healingCell proliferationFGF-2Glycosaminoglycan concentrationSoluble proteoglycanFactor 2Immunoblot analysisVivo sourceHeparan sulfatePotent promoterFirst evidenceSyndecan-4Proteoglycans