2023
Phototherapy Restores Deficient Type I IFN Production and Enhances Antitumor Responses in Mycosis Fungoides
Yu Z, Vieyra-Garcia P, Benezeder T, Crouch J, Kim I, O'Malley J, Devlin P, Gehad A, Zhan Q, Gudjonsson J, Sarkar M, Kahlenberg J, Gerard N, Teague J, Kupper T, LeBoeuf N, Larocca C, Tawa M, Pomahac B, Talbot S, Orgill D, Wolf P, Clark R. Phototherapy Restores Deficient Type I IFN Production and Enhances Antitumor Responses in Mycosis Fungoides. Journal Of Investigative Dermatology 2023, 144: 621-632.e1. PMID: 37716650, PMCID: PMC10922223, DOI: 10.1016/j.jid.2023.06.212.Peer-Reviewed Original ResearchType I IFNType I IFN productionI IFN expressionI IFN productionI IFNUVA therapyAntitumor responseSkin lesionsIFN productionIFN expressionMycosis fungoides skin lesionsType I IFN expressionAntigen-specific T cell activationEffective tumor clearanceType I interferon productionEnhanced antitumor responseSun-protected skinIFN response genesI interferon productionT cell activationType I IFN gene expressionIFN gene expressionTumor clearanceMycosis fungoidesEffective therapy
2021
CD1a selectively captures endogenous cellular lipids that broadly block T cell response
Cotton R, Wegrecki M, Cheng T, Chen Y, Veerapen N, Le Nours J, Orgill D, Pomahac B, Talbot S, Willis R, Altman J, de Jong A, Van Rhijn I, Clark R, Besra G, Ogg G, Rossjohn J, Moody D. CD1a selectively captures endogenous cellular lipids that broadly block T cell response. Journal Of Experimental Medicine 2021, 218: e20202699. PMID: 33961028, PMCID: PMC8111460, DOI: 10.1084/jem.20202699.Peer-Reviewed Original ResearchConceptsNatural endogenous inhibitorsEndogenous lipidsCD1a proteinCellular lipidsT cell activationMembrane phospholipidsLonger lipidsSurface residuesEndogenous inhibitorLipidomics methodDetailed chemical structureCell activationLipidsCellsNatural blockerSphingolipidsDisplay platformProteinCrystal structureResiduesCell responsesBindingTetramerC42Sphingomyelin