2022
Regulatory T Cells: Liquid and Living Precision Medicine for the Future of VCA
Kauke-Navarro M, Knoedler S, Panayi AC, Knoedler L, Noel OF, Pomahac B. Regulatory T Cells: Liquid and Living Precision Medicine for the Future of VCA. Transplantation 2022, 107: 86-97. PMID: 36210500, DOI: 10.1097/tp.0000000000004342.Peer-Reviewed Original ResearchConceptsSolid organ transplantationOrgan transplantationSide effectsField of VCAMedication side effectsBeneficial clinical effectsChimeric antigen receptorSevere side effectsRisk of infectionT cell receptorMaintenance immunosupressionMetabolic complicationsClinical effectsTransplant rejectionLifelong immunosuppressionImmune cellsTregsComposite allotransplantationSpecific antigenTherapeutic efficacyAntigen receptorStable levelPrecision medicineImmune system mechanismsImmunotolerance
2018
Living Donation of Vascularized Composite Allografts
Pomahac B, Alhefzi M, Bueno E, McDiarmid S, Levin L. Living Donation of Vascularized Composite Allografts. Plastic & Reconstructive Surgery 2018, 142: 405e-411e. PMID: 29927830, DOI: 10.1097/prs.0000000000004659.Peer-Reviewed Original ResearchConceptsComposite allotransplantationComposite allograftsOrgan procurementSolid organ transplantationVascularized Composite AllograftsKidney transplant communityCurrent guidelinesOrgan transplantationTransplant communityTransplantation SocietyClinical scenariosReconstructive strategiesAesthetic outcomeTransplantation NetworkReconstructive ladderReconstructive surgeonTransplant medicineOrgan donationAllotransplantationMedicaid ServicesEthics CommitteeAllograftsDonationSpecific recommendationsExtensive typeExtracorporeal Perfusion in Vascularized Composite Allotransplantation
Kueckelhaus M, Puscz F, Dermietzel A, Dadras M, Fischer S, Krezdorn N, Pomahac B, Hirsch T. Extracorporeal Perfusion in Vascularized Composite Allotransplantation. Annals Of Plastic Surgery 2018, 80: 669-678. PMID: 29746324, DOI: 10.1097/sap.0000000000001477.Peer-Reviewed Original ResearchConceptsVascularized Composite AllotransplantationSolid organ transplantationIschemia timeMachine perfusionOrgan transplantationReconstructive surgeryComposite allotransplantationClinical solid organ transplantationMachine perfusion systemImmunosuppressive treatmentGraft immunogenicityBroad clinical applicationLifelong monitoringTherapeutic measuresPerfusion strategyClinical successSevere injuriesPerfusion solutionPreclinical trialsClinical settingPlastic surgeryPerfusionImmunogenicityPerfusion systemClinical applicationFacial restoration by transplantation
Kollar B, Pomahac B. Facial restoration by transplantation. The Surgeon 2018, 16: 245-249. PMID: 29490887, DOI: 10.1016/j.surge.2018.01.003.Peer-Reviewed Original ResearchConceptsWorld War I.World War IIModern plastic surgerySir Harold GilliesPeter Bent Brigham HospitalWar IIFace transplantationFirst successful kidney transplantationJoseph MurraySuccessful kidney transplantationNobel PrizeWorldFacial restorationKidney transplantationTransplant cohortUnique patientsWomen's HospitalSkin graftsOrgan transplantationTransplantationHospitalPlastic surgeonsPlastic surgerySoldiersBattlefield
2017
Chronic Allograft Deterioration: A Clinical Reality in Vascularized Composite Allotransplantation
Krezdorn N, Pomahac B. Chronic Allograft Deterioration: A Clinical Reality in Vascularized Composite Allotransplantation. American Journal Of Transplantation 2017, 17: 1703-1704. PMID: 28371193, DOI: 10.1111/ajt.14291.Peer-Reviewed Original Research
2016
Facial Transplantation
Aycart M, Alhefzi M, Kueckelhaus M, Fischer S, Dermietzel A, Wo L, Bueno E, Pribaz J, Pomahac B. Facial Transplantation. 2016, 5: 93-102. DOI: 10.1159/000444969.Peer-Reviewed Original ResearchAcute rejectionFacial transplantationDevastating facial injuriesPulse-dose corticosteroidsSolid organ transplantationThorough preoperative planningDonor pool expansionShort-term resultsPowerful clinical toolChronic rejectionDose corticosteroidsHost diseaseImmunomodulatory approachesGraft preservationCertain patientsFunctional outcomeOrgan transplantationFacial injuriesMultidisciplinary teamSensory functionClinical toolPatient safetyPreoperative planningPsychosocial outcomesTransplantation
2015
Initial Experience of Dual Maintenance Immunosuppression With Steroid Withdrawal in Vascular Composite Tissue Allotransplantation
Diaz-Siso J, Fischer S, Sisk G, Bueno E, Kueckelhaus M, Talbot S, Carty M, Treister N, Marty F, Milford E, Pomahac B, Tullius S. Initial Experience of Dual Maintenance Immunosuppression With Steroid Withdrawal in Vascular Composite Tissue Allotransplantation. American Journal Of Transplantation 2015, 15: 1421-1431. PMID: 25777324, DOI: 10.1111/ajt.13103.Peer-Reviewed Original ResearchConceptsAcute rejectionVCA recipientsMaintenance immunosuppressionSteroid-resistant acute rejectionLate acute rejectionSolid organ transplantationComposite tissue allotransplantationMaintenance steroidsTopical immunosuppressionCurrent immunosuppressionSteroid withdrawalBolus treatmentOrgan transplantationLow doseImmunosuppressionTissue allotransplantationInitial experienceFurther experienceSteroidsRecipientsTacrolimusPatientsTreatmentMonthsLow levels
2014
Fortschritte in der Gesichtstransplantation
Kueckelhaus M, Lehnhardt M, Fischer S, Eriksson E, Pomahac B, Hirsch T. Fortschritte in der Gesichtstransplantation. Handchirurgie · Mikrochirurgie · Plastische Chirurgie 2014, 46: 206-213. PMID: 25162238, DOI: 10.1055/s-0034-1385850.Peer-Reviewed Original ResearchConceptsVascularised composite allotransplantationFace transplantationLife-threatening side effectsSolid organ transplantationDifferent transplant centersImmunosuppressive regimensMaintenance immunosuppressionVCA proceduresImmunosuppressive strategiesTransplant centersPatients' qualityLifelong immunosuppressionOrgan preservationSurgical techniqueOrgan transplantationComposite allograftsComposite allotransplantationSide effectsTransplantationFunctional reintegrationImmunosuppressionAnatomic structuresImmunogenic partFirst caseDifferent protocols