2024
Evolution of Vascularized Composite Allotransplantation
Huelsboemer L, Pomahac B. Evolution of Vascularized Composite Allotransplantation. 2024, 15-27. DOI: 10.1007/978-3-031-57132-9_3.Peer-Reviewed Original ResearchVascularized composite allotransplantationSolid organ transplantationProlongation of ischemia timeReconstruction of complex tissue defectsContext of vascularized composite allotransplantationDevelopment of non-toxicTolerogenic strategiesChronic rejectionImmunosuppressive medicationsTolerance inductionComplex tissue defectsPatient selectionIschemia timeLetter in Reply to Comment on: Gynecomastia Surgery in 4996 Male Patients Over 14 Years: A Retrospective Analysis of Surgical Trends, Predictive Risk Factors, and Short-Term Outcomes
Kauke-Navarro M, Klimitz F, Pomahac B. Letter in Reply to Comment on: Gynecomastia Surgery in 4996 Male Patients Over 14 Years: A Retrospective Analysis of Surgical Trends, Predictive Risk Factors, and Short-Term Outcomes. Aesthetic Plastic Surgery 2024, 1-3. PMID: 39085527, DOI: 10.1007/s00266-024-04285-7.Peer-Reviewed Original ResearchC-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via subset-selective monocyte activation
Kiefer J, Zeller J, Schneider L, Thomé J, McFadyen J, Hoerbrand I, Lang F, Deiss E, Bogner B, Schaefer A, Chevalier N, Horner V, Kreuzaler S, Kneser U, Kauke-Navarro M, Braig D, Woollard K, Pomahac B, Peter K, Eisenhardt S. C-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via subset-selective monocyte activation. Journal Of Advanced Research 2024 PMID: 38992424, DOI: 10.1016/j.jare.2024.07.007.Peer-Reviewed Original ResearchAcute allograft rejectionC-reactive proteinVascularized composite allotransplantationAllograft rejectionAcute rejectionAllograft survivalGraft rejectionAttenuate acute allograft rejectionPreventing acute allograft rejectionImmune responseLong-term allograft survivalFacial vascularized composite allotransplantationClinical allograft rejectionReduced allograft survivalChronic allograft rejectionIntravital imagingNon-classical monocytesMarkers of inflammationAcute-phase reactantsImmune-inflammatory reactionPro-inflammatory propertiesMononuclear phagocyte systemAcute-phase responseGraft infiltrationInnate immune responseSurgical Management of Breast Capsular Contracture—A Multi-institutional Data Analysis of Risk Factors for Early Complications
Knoedler S, Knoedler L, Boroumand S, Alfertshofer M, Diatta F, Sofo G, Huelsboemer L, Hansen F, Könneker S, Kim B, Perozzo F, Ayyala H, Allam O, Pomahac B, Kauke-Navarro M. Surgical Management of Breast Capsular Contracture—A Multi-institutional Data Analysis of Risk Factors for Early Complications. Aesthetic Plastic Surgery 2024, 1-12. PMID: 38926252, DOI: 10.1007/s00266-024-04203-x.Peer-Reviewed Original ResearchRisk factorsPostoperative complicationsCC surgeryInpatient settingMedical complicationsAmerican College of Surgeons National Surgical Quality Improvement Program databaseRisk factors of postoperative complicationsSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseImplant-based breast surgeryMultivariate analysisPreoperative diagnosis of hypertensionFactors of postoperative complicationsQuality Improvement Program databaseLevel of Evidence IIIThis journalEvidence-Based Medicine ratingsAnalysis of risk factorsDay complication ratesDays follow-upEvidence IIIThis journalLevel of evidenceSurgical adverse eventsDiagnosis of hypertensionMulti-institutional dataTreatment of CCA Nationwide Analysis on Major Upper Extremity Amputations and Replantations.
Stögner V, Hauc S, Hosseini H, Williams M, Boroumand S, Huelsboemer L, Kauke-Navarro M, Pomahac B, Colen D. A Nationwide Analysis on Major Upper Extremity Amputations and Replantations. Hand 2024, 15589447241259189. PMID: 38907654, DOI: 10.1177/15589447241259189.Peer-Reviewed Original ResearchUpper extremity amputationExtremity amputationTraumatic upper extremity amputationsUtilization Project's National Inpatient SampleProportion of amputationsUrban teaching hospitalLevel of injuryNational Inpatient SampleNontraumatic amputationsUnited StatesHospital typeLength of stayInternational ClassificationTraumatic amputationHealthcare costsHighest burdenUpper extremityAlcohol useTeaching hospitalInpatient SamplePool of casesAmputationNational trendsNationwide analysisLow likelihoodQuality of life and satisfaction after breast augmentation: A systematic review and meta-analysis of Breast-Q patient-reported outcomes
Knoedler S, Knoedler L, Kauke-Navarro M, Alfertshofer M, Obed D, Broer N, Kim B, Könneker S, Panayi A, Hundeshagen G, Kneser U, Pomahac B, Haug V. Quality of life and satisfaction after breast augmentation: A systematic review and meta-analysis of Breast-Q patient-reported outcomes. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 95: 300-318. PMID: 38945110, DOI: 10.1016/j.bjps.2024.06.016.Peer-Reviewed Original ResearchPhysical well-beingSexual well-beingWell-beingPatient-reported physical well-beingPatient reportsMeta-analysisPsychosocial well-beingPatient-reported outcomesPatient-reported quality of lifeBreast augmentationQuality of lifeHigher QoLPairwise meta-analysisA systematic reviewPatients' QoLPatient satisfactionSystematic reviewEligibility criteriaPRISMA guidelinesPostoperative follow-up timeQoLQuantitative synthesisFollow-up timeSubgroup analysisSatisfactionUnderstanding Epidemiological Trends in Geriatric Burn Injuries: A National Multicenter Analysis from NEISS 2004-2022
Boroumand S, Katsnelson B, Dony A, Stögner V, Huelsboemer L, Parikh N, Oh S, Kauke-Navarro M, Savetamal A, Pomahac B. Understanding Epidemiological Trends in Geriatric Burn Injuries: A National Multicenter Analysis from NEISS 2004-2022. Journal Of Burn Care & Research 2024, irae102. PMID: 38842413, DOI: 10.1093/jbcr/irae102.Peer-Reviewed Original ResearchGeriatric patientsRisk of hospital admissionAwareness of preventive measuresBurn injuryAffected body partED mortalityBurn epidemiologyNEISS databaseAdult patientsHospital admissionVulnerable populationsPatient morbidity/mortalityEpidemiological trendsLower legBurn etiologyProportion Z testAge groupsInjury sourcesMulticenter samplePatients to datePreventive measuresIncident locationLower armZ-testMulticenter analysisFuture of autologous breast reconstruction: a review of novel technological innovations
Allam O, Foster C, Knoedler L, Knoedler S, Oh S, Pomahac B, Ayyala H. Future of autologous breast reconstruction: a review of novel technological innovations. Plastic And Aesthetic Research 2024, 11: n/a-n/a. DOI: 10.20517/2347-9264.2024.21.Peer-Reviewed Original ResearchP18. Development And Comparative Evaluation Of Computer-based Assessment Tools for Manual and Robotic Microsurgery
Stögner V, Wessel K, Yu C, Boroumand S, Xie M, Ji H, Shi A, Wong A, Huelsboemer L, Pomahac B, Hirsch T, Kueckelhaus M, Ayyala H. P18. Development And Comparative Evaluation Of Computer-based Assessment Tools for Manual and Robotic Microsurgery. Plastic & Reconstructive Surgery Global Open 2024, 12: 47-48. DOI: 10.1097/01.gox.0001018340.00626.9c.Peer-Reviewed Original ResearchD111. Ten year Follow up after Face Transplantation
Huelsboemer L, Kauke-Navarro M, Boroumand S, Parikh N, Hosseini H, Yu C, Stögner V, Ko C, Perry B, Formica R, Hung P, Mahajan A, Azzi J, Murphy G, Pomahac B. D111. Ten year Follow up after Face Transplantation. Plastic & Reconstructive Surgery Global Open 2024, 12: 120-121. DOI: 10.1097/01.gox.0001018916.83172.5e.Peer-Reviewed Original ResearchD41. Preclinical Performance Of The Combined Application Of Two Robotic Systems In Microsurgery - A Two-center Study
Ayyala H, Stögner V, Wessel K, Yu C, Pomahac B, Hirsch T, Kueckelhaus M. D41. Preclinical Performance Of The Combined Application Of Two Robotic Systems In Microsurgery - A Two-center Study. Plastic & Reconstructive Surgery Global Open 2024, 12: 88-88. DOI: 10.1097/01.gox.0001018660.23172.00.Peer-Reviewed Original ResearchPreclinical Performance of the Combined Application of Two Robotic Systems in Microsurgery: A Two-center Study
Wessel K, Stögner V, Yu C, Pomahac B, Hirsch T, Ayyala H, Kueckelhaus M. Preclinical Performance of the Combined Application of Two Robotic Systems in Microsurgery: A Two-center Study. Plastic & Reconstructive Surgery Global Open 2024, 12: e5775. PMID: 38689940, PMCID: PMC11057809, DOI: 10.1097/gox.0000000000005775.Peer-Reviewed Original ResearchRobotic systemRobotic setupMicrosurgery systemMicrosurgical robotRobotic devicesDevelopment of robotic devicesRobotSurgical timeRobotic microscopeRobotic approachRobotic assistanceSteep learning curveTwo-center studyAnastomosis qualityPerformanceTwo-center trialRobotic microsurgeryImproved precisionAccelerated skill acquisitionFrom standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases
Knoedler L, Huelsboemer L, Hollmann K, Alfertshofer M, Herfeld K, Hosseini H, Boroumand S, Stoegner V, Safi A, Perl M, Knoedler S, Pomahac B, Kauke-Navarro M. From standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases. Frontiers In Immunology 2024, 15: 1276306. PMID: 38715609, PMCID: PMC11074450, DOI: 10.3389/fimmu.2024.1276306.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsHead and neck cancerBreast cancerMonoclonal antibodiesCheckpoint inhibitorsSkin cancerReconstructive surgeryNon-surgical treatment strategiesProlonged progression-free survivalSuboptimal treatment plansProgression-free survivalNon-surgical therapySurgical tumor resectionImpaired patient outcomeStandardized treatment algorithmSurgical therapy planningAnti-cancer strategyUnresectable tumorsConventional chemotherapyRemission rateTumor resectionCurative therapyTargeted therapyNeck cancerOncology cases12. Functional Long-Term Outcome Of Eight Face Transplant Patients - A Single Center Study
Huelsboemer L, Stoegner V, Boroumand S, Parikh N, Hosseini H, Perry B, Formica R, Kauke-Navarro M, Pomahac B. 12. Functional Long-Term Outcome Of Eight Face Transplant Patients - A Single Center Study. Plastic & Reconstructive Surgery Global Open 2024, 12: 8-9. PMCID: PMC11041197, DOI: 10.1097/01.gox.0001015140.10439.0d.Peer-Reviewed Original ResearchCellular therapeutics and immunotherapies in wound healing – on the pulse of time?
Huelsboemer L, Knoedler L, Kochen A, Yu C, Hosseini H, Hollmann K, Choi A, Stögner V, Knoedler S, Hsia H, Pomahac B, Kauke-Navarro M. Cellular therapeutics and immunotherapies in wound healing – on the pulse of time? Military Medical Research 2024, 11: 23. PMID: 38637905, PMCID: PMC11025282, DOI: 10.1186/s40779-024-00528-5.Peer-Reviewed Original ResearchConceptsStandard of careChronic wound healing disordersLocal wound irrigationWound healingChronic inflammatory microenvironmentFree flap techniqueWound healing disordersChronic woundsGenetic risk profilesPhysiological wound healingAdequate blood supplySurgical debridementFlap techniqueCellular therapyCurrent therapiesHealing disordersInflammatory microenvironmentWound irrigationNon-healing woundsCellular therapeuticsGeneral anesthesiaFormation of biofilmsWound debridementSkin graftsImmunotherapyImmune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions
Knoedler L, Dean J, Diatta F, Thompson N, Knoedler S, Rhys R, Sherwani K, Ettl T, Mayer S, Falkner F, Kilian K, Panayi A, Iske J, Safi A, Tullius S, Haykal S, Pomahac B, Kauke-Navarro M. Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions. Frontiers In Immunology 2024, 15: 1372862. PMID: 38650942, PMCID: PMC11033354, DOI: 10.3389/fimmu.2024.1372862.Peer-Reviewed Original ResearchConceptsRegulatory myeloid cellsSolid organ transplantationVascularized composite allotransplantationMesenchymal stromal cellsT cellsTransplant patientsCellular therapyChimeric antigen receptor T cellsTransplant surgerySide effectsIncreased risk of malignancyProgression to chronic rejectionAcute rejection ratesPerioperative treatment strategiesRegulatory T cellsPromote immune toleranceRisk of malignancySystemic side effectsRelated side effectsCell typesImprove transplant survivalCAR-TCell therapy applicationsImmunosuppressive regimensChronic rejectionGynecomastia Surgery in 4996 Male Patients Over 14 Years: A Retrospective Analysis of Surgical Trends, Predictive Risk Factors, and Short-Term Outcomes
Knoedler L, Knoedler S, Alfertshofer M, Hansen F, Schenck T, Sofo G, Obed D, Hollmann K, Siegwart L, Vollbach F, Bigdeli A, Kauke-Navarro M, Pomahac B. Gynecomastia Surgery in 4996 Male Patients Over 14 Years: A Retrospective Analysis of Surgical Trends, Predictive Risk Factors, and Short-Term Outcomes. Aesthetic Plastic Surgery 2024, 1-9. PMID: 38528130, DOI: 10.1007/s00266-024-03927-0.Peer-Reviewed Original ResearchACS-NSQIP databaseGynecomastia surgeryRisk factorsGS patientsACS-NSQIPBleeding disordersAmerican College of Surgeons National Surgical Quality Improvement ProgramSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramLevel of Evidence IIIThis journalSurgical Quality Improvement ProgramPreoperative risk factorsEvidence-Based Medicine ratingsInvestigate postoperative outcomesIndependent risk factorPredictive risk factorsShort-term outcomesMale adult patientsEvidence IIIThis journalPostoperative time periodLevel of evidencePredicting adverse eventsQuality Improvement ProgramGS casesGynecomastia casesImmunosuppressive strategies in face and hand transplantation: a comprehensive systematic review of current therapy regimens and outcomes
Huelsboemer L, Boroumand S, Kochen A, Dony A, Moscarelli J, Hauc S, Stögner V, Formica R, Pomahac B, Kauke-Navarro M. Immunosuppressive strategies in face and hand transplantation: a comprehensive systematic review of current therapy regimens and outcomes. Frontiers In Transplantation 2024, 3: 1366243. PMID: 38993787, PMCID: PMC11235358, DOI: 10.3389/frtra.2024.1366243.Peer-Reviewed Original ResearchCMV infectionImmunosuppressive regimensImmunosuppressive strategiesTransplant recipientsIncidence of rejection episodesClinical CMV infectionTriple maintenance therapyIncidence of rejectionEpisodes of rejectionIndividualized immunosuppressive regimensEffective immunosuppressive therapySystematic reviewFace transplant patientsHand transplant recipientsHand transplantationFacial graftImmunosuppressive therapyMaintenance therapyRejection episodesFacial mucosaGraft lossGraft rejectionTherapy regimensTransplant patientsRenal failureLymphadenopathy and lymph node rejection following facial vascularized composite allotransplantation
Kauke-Navarro M, Sadigh S, Lee C, Panayi A, Knoedler L, Knoedler S, Stoegner V, Huelsboemer L, Jamil A, Ko C, Lian C, Murphy G, Pomahac B. Lymphadenopathy and lymph node rejection following facial vascularized composite allotransplantation. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 91: 268-275. PMID: 38430863, DOI: 10.1016/j.bjps.2024.02.024.Peer-Reviewed Original ResearchLymph nodesVascularized composite allograftsGranzyme BDonor-derived immune cellsFacial vascularized composite allograftMedian time of presentationFacial vascularized composite allotransplantationImmunological processesGranzyme B expressionCytotoxic T cellsNecrotizing histiocytic lymphadenitisHead and neckRetrospective cohort studyTime of presentationStages of follow-upCoexistence of donorFace transplant patientsBilateral adenopathyIncreased histiocytesSuperficial lymph nodesVascularized composite allotransplantationBilateral lymphadenopathyAllograft rejectionTransplant patientsDendritic cellsIsolated and combined breast augmentation in transgender patients: Multi-institutional insights into early outcomes and risk factors
Knoedler S, Knoedler L, Geldner B, Ghanad I, Kim B, Alfertshofer M, Machens H, Broer P, Pomahac B, Kauke-Navarro M, Paik A. Isolated and combined breast augmentation in transgender patients: Multi-institutional insights into early outcomes and risk factors. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 90: 149-160. PMID: 38367411, DOI: 10.1016/j.bjps.2024.01.026.Peer-Reviewed Original ResearchBreast augmentation surgeryNational Surgical Quality Improvement ProgramBody mass indexGender-affirming surgeryAmerican College of SurgeonsAdverse eventsAmerican Society of Anesthesiology class 1Advanced ageEvaluate 30-day outcomesRisk factorsSurgical Quality Improvement ProgramPositive safety profileSurgical decision-makingNo adverse eventsIncidence of mortalityIdentified risk factorsCombined surgeryQuality Improvement ProgramGenitourinary proceduresGenitourinary surgeryNicotine abuseAugmentation surgeryBreast augmentationComplication ratePostoperative outcomes