Clarence Takashi Sasaki, MD, FACS

Charles W. Ohse Professor of Surgery (Otolaryngology)

Research Organizations

Surgery: Otolaryngology Surgery: Head & Neck Cancer Surgery Program; Larynx Lab

Yale Cancer Center: Developmental Therapeutics

Office of Cooperative Research

Selected Publications

  • In vivo short term topical application of BAY 11-7082 prevents the acidic bile-induced mRNA and miRNA oncogenic phenotypes, in exposed murine hypopharyngeal mucosa Sasaki C.T, Doukas S, Vageli D: In vivo short term topical application of BAY 11-7082 prevents the acidic bile-induced mRNA and miRNA oncogenic phenotypes, in exposed murine hypopharyngeal mucosa. Neoplasia 2018.
  • NF-κB inhibition reverses acidic bile-induced miR-21, miR-155, miR-192, miR-34a, miR-375 and miR-451a deregulations in human hypopharyngeal cells. Doukas S, Vageli D, Sasaki C.T: NF-κB inhibition reverses acidic bile-induced miR-21, miR-155, miR-192, miR-34a, miR-375 and miR-451a deregulations in human hypopharyngeal cells. J Cell Molecular Med 2018.
  • Inhibition of NFkB prevents the acidic bile-induced oncogenic mRNA phenotype in human hypopharyngeal cells. Vageli DP, Soukas SG, Sasaki C.T. (2017). Inhibition of NFkB prevents the acidic bile-induced oncogenic mRNA phenotype in human hypopharyngeal cells. Oncotarget 2017.
  • PDL1 expressing tumor cells (CTC’s) in patients with head and neck squamous cell carcinoma (HNSCC). Strati A, Koutsodontis G, Angelidis I, Sasaki C.T., Avgeris M, Lianidou E, Psyrri A: PDL1 expressing tumor cells (CTC’s) in patients with head and neck squamous cell carcinoma (HNSCC). Ann Oncol 2017.
  • Application of extended H plate to open reduction internal fixation of the mandibular condyle. Arronson NL, Sasaki C.T., Lowlicht RA: Application of extended H plate to open reduction internal fixation of the mandibular condyle. Oral Surg. 2017 May;10(2):112-116
  • Laryngeal Cancer Sasaki C.T., Pierce M: Laryngeal Cancer, Best Practice/Point of Care 2017, British Medical Journal
  • Treatment guidelines and patterns of care in oral cavity squamous cell carcinoma: Primary surgical resection vs. nonsurgical treatment. Fujiwara R, Burtness B, Husain Z, Judson B, Bhatia A, Sasaki C.T., Yarbrough W, Mehra S: Treatment guidelines and patterns of care in oral cavity squamous cell carcinoma: Primary surgical resection vs. nonsurgical treatment. Oral Oncology 2017 Aug; 71:129-137.
  • HPV positive oropharyngeal cancer via p16 immunohistochemistry in Japan. Toman J, Larson S, Umeno H, Kurita T, Furusaka T, Hasegawa H, Prasad ML, Sasaki C. T: HPV positive oropharyngeal cancer via p16 immunohistochemistry in Japan. Ann. Otol. Rhinol. Laryngol. 2017 Feb;126(2):152-158
  • A review of 30 years head and neck flap reconstruction at a single institution. Sun AH, Yu X, Sasaki C.T., Ariyan S, Steinbacher D: A review of 30 years head and neck flap reconstruction at a single institution. J Craniofacial Surg 2016.
  • In vitro effect of acidic-pepsin in NF-kB activation and its related oncogenic effect on normal human hypopharyngeal cells. Sasaki C. T; Toman J, Vageli D: In vitro effect of acidic-pepsin in NF-kB activation and its related oncogenic effect on normal human hypopharyngeal cells, PLOS ONE 2016 11(12).
  • Pedicle v. free flap reconstruction in patients receiving intraoperative brachytherapy. Geiger E, Basques BA, Chang C, Son Y, Sasaki C.T, McGregor A, Ariyan S, Narayan D; Pedicle v. free flap reconstruction in patients receiving intraoperative brachytherapy. J. Plastic Surg. And Hand Surg. 2016 Mar 50(4):227-232
  • miR-21, miR-155, miR-192, miR-375 Deregulations related to NFkB activation in gastro-duodenal fluid induced early preneoplastic lesions of laryngeal mucosa in vivo. Sasaki C.T, Vageli D. miR-21, miR-155, miR-192, miR-375 Deregulations related to NFkB activation in gastro-duodenal fluid induced early preneoplastic lesions of laryngeal mucosa in vivo. Neoplasia. 2016 18 (6) 329–338.
  • Gastroduodenal fluid induced nuclear factor-kappa B activation and early premalignant alterations in murine hypopharyngeal mucosa. Vageli DP, Prasad ML, Sasaki C.T. Gastroduodenal fluid induced nuclear factor-kappa B activation and early premalignant alterations in murine hypopharyngeal mucosa. Oncotarget, 2016.
  • Is the external branch of the superior laryngeal nerve dispensable in thyroid surgery? Folk D, Wahba B, Sasaki C.T. Is the external branch of the superior laryngeal nerve dispensable in thyroid surgery? Thyroid 2016 Jan;26(1):169-73.
  • External branch of the superior laryngeal nerve mediated glottic closing force in the porcine model. Folk D, Paskhover B, Wadie M, Wahba B, Sasaki C.T. External branch of the superior laryngeal nerve mediated glottic closing force in the porcine model. Ann Otol Rhinol Laryngol 2016 May;125(5):421-4.
  • Evaluation of PD-L1 expression and associated tumor infiltrating lymphocytes in laryngeal squamous cell carcinoma. Vasilakopoulou, M., Velcheti, V, Rampias, T., Sasaki, C.T., Rimm, D., Fountzillas, G., Psyrri, A. Evaluation of PD-L1 expression and associated tumor infiltrating lymphocytes in laryngeal squamous cell carcinoma. Clinical Cancer Research 2016 Feb 1;22(3):704-13.
  • An in vitro model for gastroduodenal reflux-induced nuclear factor-kappaB activation and its role in hypopharyngeal carcinogenesis. Sasaki, C.T., Issaeva, N., Vageli, D. An in vitro model for gastroduodenal reflux-induced nuclear factor-kappaB activation and its role in hypopharyngeal carcinogenesis. Head & Neck 2016, 38 (S1): E1381–E1391.
  • An unusual morphology of a pleomorphic adenoma. Aaronson, N., C.A. Schutt and C.T. Sasaki. An unusual morphology of a pleomorphic adenoma. Connecticut Medicine 2015, 79(1):27-9.
  • Is partial laryngectomy safe forever? Bagwell, K., S. Leder and C.T. Sasaki. Is partial laryngectomy safe forever? American Journal of Otolaryngology 2015, 36(3):437-41.
  • Carotid stent extrusion following carotid blowout. Aaronson, N., M. Johnson and C.T. Sasaki. Carotid stent extrusion following carotid blowout. Auris, Nasus, Larynx 2015, 42(2):176-8.
  • Delayed myocutaneous turnover flap for repair of pharyngocutaneous fistula. Neubauer, P., K. Canadas and C.T. Sasaki. Delayed myocutaneous turnover flap for repair of pharyngocutaneous fistula. American Journal Otolaryngology 2015, 36:93.96.
  • Molecular mechanisms of HPV induced carcinogenesis in head and neck. Rampias T, C.T. Sasaki, Psyrri A. Molecular mechanisms of HPV induced carcinogenesis in head and neck. Oral Oncology, 2014, 50, 356-363.
  • Markers of epithelial to mesenchymal transition in association with survival in head and neck squamous cell carcinoma (HNSCC) Pectasides E, Rampias T, C.T. Sasaki, Perisanidis C, Kouloulias V, Burtness B, Zaramboukas T, Rimm D, Fountzilas G, Psyrri A. Markers of epithelial to mesenchymal transition in association with survival in head and neck squamous cell carcinoma (HNSCC). PloS One. 2014, 9. e94273, doi:10.1371/journal.pone.0094273.
  • RAS/P13K crosstalk and cetuximab resistance in head and neck squamous cell carcinoma. Rampias T, Giagini A, Siolos S, Matsuzaki H, C. T. Sasaki, Scorilas A, Psyrri A. RAS/P13K crosstalk and cetuximab resistance in head and neck squamous cell carcinoma. Clinical Cancer Research. 2014, 20(11), pp. 2933-2946.
  • Pharyngeal plexus mediated glottic closure response and other associated neural connections of the plexus. Paskhover, B., M. Wadie and C.T. Sasaki. Pharyngeal plexus mediated glottic closure response and other associated neural connections of the plexus. JAMA Otolaryngology-Head and Neck Surgery 2014, 140(11):1056-60.
  • Laryngeal Cancer Larson, S., H. Deshpande and C.T. Sasaki. Laryngeal Cancer. British Medical Journal 2014.
  • Thyroarytenoid Cross Innervation by the External Branch of the Superior Laryngeal Nerve in the Porcine Model. Paskhover, B., M. Wadie and C.T. Sasaki. Thyroarytenoid Cross Innervation by the External Branch of the Superior Laryngeal Nerve in the Porcine Model. Laryngoscope 2014, 125(1):177-9.
  • A histological examination of the quadrangular membrane. Young, N. and C.T. Sasaki. Hajek revisited: A histological examination of the quadrangular membrane. Annals of Otology, Rhinology & Laryngology 2014, 123(11):765-8.
  • Impact of Dairy Consumption on Salivary Inoculum. Schutt, C., P. Neubauer, B. Paskhover, F. Li and C.T. Sasaki. Impact of Dairy Consumption on Salivary Inoculum. Dysphagia 2014, 29: 277-83.
  • Contribution of Pharyngeal Plexus to Vocal Cord Adduction. Matsuzaki, H., B. Paskhover, C.T. Sasaki. Contribution of Pharyngeal Plexus to Vocal Cord Adduction. Laryngoscope 2014, 124 (2):516-21.
  • Multi-drug Resistance in Mucoepidermoid Carcinoma of the Parotid Gland-Immunohistochemical Investigations of P-Glycoprotein Expression. Furusaka, T., C.T. Sasaki, A. Matsuda, Y. Sasaki, H. Matsuda and M. Ikeda. Multi-drug Resistance in Mucoepidermoid Carcinoma of the Parotid Gland-Immunohistochemical Investigations of P-Glycoprotein Expression. Acta Otolaryngologica 2013, 133:552-7.
  • Tall Cell Variant of Tall Cell Thyroid Microcarcinoma: Clinical Features and BRAF mutation Berstein, J., R. Virk, W. Westra, G. Tallini, P. Hui, A. Adeniran, R. Udelsman and C.T. Sasaki, S. Roman, J. Sosa, A. Prasad and M. Prasad. Tall Cell Variant of Tall Cell Thyroid Microcarcinoma: Clinical Features and BRAF mutation. Thyroid 2013, 23:1525-31.
  • CO2 laser fiber for the excision of oral leukoplakia: A randomized clinical trial Chee, M. and C.T. Sasaki. CO2 laser fiber for the excision of oral leukoplakia: A randomized clinical trial. Annals of Otology, Rhinology & Laryngology 2013, 172 (9):547-9.
  • Molecular Profile of Head & Neck Squamous Cell Carcinomas bearing p16 high phenotype. Rampias, T., E. Pectasides, M. Prasad, C.T. Sasaki, P. Gouveris, A. Dimou, P. Kountourakis, C. Perisanidis, B. Burtness, T. Zaramboukas, D. Rimm, D. Fountzilas and A. Psyrri. Molecular Profile of Head & Neck Squamous Cell Carcinomas bearing p16 high phenotype. Annals of Oncology 2013, 24 (8):2124-31.
  • Revision of Zenkers Diverticulum: Laser vs. Stapler Outcomes following initial endoscopic failure. Adam, S.I., B. Paskhover and C.T. Sasaki. Revision of Zenkers Diverticulum: Laser vs. Stapler Outcomes following initial endoscopic failure. Annals of Otology, Rhinology & Laryngology 2013, 122 (4):247-53.
  • Laryngeal Cancer, Best Practice/Point of Care Update Deshpande, H. and C.T. Sasaki. Laryngeal Cancer, Best Practice/Point of Care Update 2012. British Medical Journal, 2012.
  • Laser vs. Stapler: Outcomes in Endoscopic Repair of Zenkers Diverticulum. Adam SI, Pashkover B, Sasaki CT: Laser vs. Stapler: Outcomes in Endoscopic Repair of Zenkers Diverticulum, Laryngoscope, 122:1961-6, 2012.
  • Future Directions in Research, treatment, and Prevention of HPV-related SCC of the Head & Neck. Psyrri, A., C.T. Sasaki, M. Vasilakopoulou, S. Dimitriadis, and T. Rampias. Future Directions in Research, treatment, and Prevention of HPV-related SCC of the Head & Neck. Head & Neck Pathology 2012, 6:121-128.
  • Sequence-Specific biosensors report drug induced changes in epigenetic silencing Huang, X., R. Narayanaswamy, K. Fenn, C.T. Sasaki, J. Costa, P. Blancafort and P.M. Lizardi. Sequence-Specific biosensors report drug induced changes in epigenetic silencing. DNA and Cell Biology. 2012, 31: (S1):S-2 – S-10.
  • An Evaluation of the Routine use of Contrast Radiography as a Screening Test for Cervical Anastomatic Integrity after Esophagectomy. Solomon, D., C.T. Sasaki and R.R. Salem. An Evaluation of the Routine use of Contrast Radiography as a Screening Test for Cervical Anastomatic Integrity after Esophagectomy. American Journal of Surgery 2012, 203(4):467-471.
  • A Neuromuscular Basis for Ventricular Fold Function. Young, N., M. Wadie and C.T. Sasaki. A Neuromuscular Basis for Ventricular Fold Function, Annals of Otology, Rhinology & Laryngology 2012, 121:317-21.
  • Effect of Altered Core Body Temperature on Glottic Closing Force. Wadie, M., J. Li and C.T. Sasaki. Effect of Altered Core Body Temperature on Glottic Closing Force. Annals of Otology, Rhinology & Laryngology 2011, 120(10):669-673.
  • Response of Cricopharyngeus Muscle to Esophageal Stimulation by Mechanical Distension, Acid and Bile Perfusion. Chernichenko, N., J.S. Woo, J. Hundal, C.T. Sasaki. Response of Cricopharyngeus Muscle to Esophageal Stimulation by Mechanical Distension, Acid and Bile Perfusion. Annals of Otology, Rhinology & Laryngology 2011, 120(2): 137-143.
  • Comparative prognostic value of epidermal growth factor quantitative protein expression compared with FISH for head and neck squamous cell carcinoma. Pectasides E, Rampias T, Kountourakis P, C. T. Sasaki, Kowalski D, Fountzilas G, Zaramboukas T, Rimm D, Burtness B, Psyrri A. Comparative prognostic value of epidermal growth factor quantitative protein expression compared with FISH for head and neck squamous cell carcinoma. Clin Cancer Res. 2011,9:2947-54.
  • Preoperative endoscopic airway examination (PEAE) provides superior airway information and may reduce the use of unnecessary awake intubation.

    Rosenblatt, W., A. Ianus, W. Sukhupragarn, A. Fickenscher and C.T. Sasaki. Preoperative Endoscopic Airway Examination (PEAE) Provides Superior Airway Information and Reduces the Use of Unnecessary Awake Intubation. Anesthesia and Analgesia 2011, 112(3):602-607.

  • From Virtual Reality to the Operating Room: The Endoscopic Sinus Surgery Simulator Experiment.

    Fried, M.D., B. Sadoughi, M.J. Gibber, J.B. Jacobs, R.A. Lebowitz, D.A. Ross, J.P. Bent III, S.R. Parikh, C.T. Sasaki and S.D. Schaefer. From Virtual Reality to the Operating Room: The Endoscopic Sinus Surgery Simulator Experiment. Otolaryngology - Head and Neck Surgery 2010, 142(2):202-207.

  • Pectasides E, Egloff A, Sasaki CT, Burtness B, Fountzilas G, Dafni V, Zaramboukas T, Rimm D, Grandis J, Psyrri A: Nuclear Localization of Signal Transducer of Transcription 3 (STAT3) in Head and Neck Squamous Cell Carcinoma is Associated with a Better Prognosis, accepted Clin Can Res, 2010
  • Prasad S, Cody V, Hanlon J, Sawyer J, Sasaki CT, Edelson R, Birchall M, Saltzman MW: Polymer Nanoparticles Containing Tumor Lysates as Antigen Delivery Vehicles for Dendritic Cell-Based Antitumor Immunotherapy, accepted J. Nanomedicine, 2010
  • Chernichenko N, Woo JS, Hundal J, Sasaki CT: Response of Cricopharyngeus Muscle to Esophageal Stimulation by Mechanical Distension, Acid and Bile Perfusion, accepted Ann Otol Rhinol Laryngol, 2010
  • Rampias T, Boutati E, Pectasides E, Sasaki CT, Panteleimon K, Weinberger P, Psyrri A: Activation of Wnt Signaling Pathway by Human Papilloma Virus (HPV) E6 and E7 Oncogenes in HPV16 Oropharyngeal Squamous Cells, Accepted Mol Can Res, 2010
  • Weinberger PM, Merkley M, Lee JR, Bao-Ling A, Gourin CG, Podolsky RH, Haffty BG, Papadavid E, Sasaki CT, Psyrri A, Dynan WS: Use of Combination Proteomic Analysis to Demonstrate Molecular Similarity of Head and Neck Squamous Cell Carcinoma Arising From Different Subsites, Arch Otolaryngol Head and Neck Surg. 135(7):694-703, 2009
  • Szpakowski S, Sun X, Lage J, Dyer A, Rubenstein J, Kowalski D, Sasaki CT, Costa J, Lizardi P: Loss of Epigenetic Silencing in Tumor Preferentially Affects Primate-Specific Retroelements, Gene. 448(2):151-67, 2009

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Contact Info

Clarence Takashi Sasaki, MD, FACS
Patient Care Locations
Yale Head & Neck Cancer ProgramYale Physicians Building
800 Howard Avenue, Ste 4th Floor

New Haven, CT 06519
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Yale Cancer CenterYale New Haven Hospital
20 York Street, Ste North Pavilion

New Haven, CT 06510
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Mailing Address
Otolaryngology Surgery330 Cedar Street
PO Box 208062

New Haven, CT 06520-8062

Curriculum Vitae

Yale Larynx Lab