2025
Relationship Between Total Parenteral Nutrition, Ventilation, and Hepatoblastoma: A Study of 258,929 Neonatal Intensive Care Unit Admissions
Hellmann Z, Rehman S, Brown L, Vasquez J, Solomon D, Christison‐Lagay E. Relationship Between Total Parenteral Nutrition, Ventilation, and Hepatoblastoma: A Study of 258,929 Neonatal Intensive Care Unit Admissions. Pediatric Blood & Cancer 2025, 72: e31741. PMID: 40275525, PMCID: PMC12209882, DOI: 10.1002/pbc.31741.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitPediatric Health Information SystemNeonatal intensive care unit admissionDays of TPNDiagnosis of hepatoblastomaMechanical ventilationGestational ageBirth weightNeonatal intensive care unit hospitalizationPediatric Health Information System hospitalsNICU interventionsDuration of TPNIntensive care unit admissionTotal parenteral nutritionLow birth weightDevelopment of hepatoblastomaIntensive care unitConditional logistic regressionParenteral nutritionUnit admissionClinical characteristicsHepatoblastomaOvergrowth syndromeVentilation exposureCare unitThe Natural History of Congenital Hepatic Hemangiomas
Ostertag-Hill C, Fevurly R, Kulungowski A, Christison-Lagay E, McGuire A, Rialon K, Duggan E, Murillo R, Zurakowski D, Staffa S, Alomari A, Kozakewich H, Al-Ibraheemi A, Fishman S, Dickie B. The Natural History of Congenital Hepatic Hemangiomas. The Journal Of Pediatrics 2025, 281: 114523. PMID: 40023218, DOI: 10.1016/j.jpeds.2025.114523.Peer-Reviewed Original ResearchCongenital hepatic hemangiomasCongenital HHHepatic hemangiomaMedical therapyRetrospective review of patientsNatural historyReview of patientsKaplan-Meier curvesMonths of ageCongenital hemangiomaRetrospective reviewClinical presentationRespiratory failureClinical behaviorHeart failureHH volumeHistological findingsEarly recognitionResidual volumeGeneralized estimating equationsIncorrect diagnosisHemangiomaPatientsNo differenceRate of involutionFunctional Outcomes for Patients With Congenital Anorectal Malformations: A Systematic Review and Evidence-based Guideline From the APSA Outcomes and Evidence Based Practice Committee
Rialon K, Smith C, Rentea R, Acker S, Baird R, Beres A, Chang H, Christison-Lagay E, Diesen D, Englum B, Gonzalez K, Gulack B, Ham P, Huerta C, Kulaylat A, Levene T, Lucas D, Mansfield S, Pennell C, Ricca R, Sulkowski J, Tashiro J, Wakeman D, Yousef Y, Kelley-Quon L, Kawaguchi A, Committee A. Functional Outcomes for Patients With Congenital Anorectal Malformations: A Systematic Review and Evidence-based Guideline From the APSA Outcomes and Evidence Based Practice Committee. Journal Of Pediatric Surgery 2025, 60: 162243. PMID: 40023107, DOI: 10.1016/j.jpedsurg.2025.162243.Peer-Reviewed Original ResearchQuality of lifeSystematic reviewStructured care planFunctional outcomesAnorectal malformationsOptimal patient counselingComplex patient populationTransitional careLevel of evidenceCare planningImprove carePatient transitionsPsychosocial issuesAdult careAmerican Pediatric Surgical Association OutcomesPsychosocial functioningCareConstipation ratePractice CommitteeAnorectal malformation patientsAssociated outcomesCongenital anorectal malformationsMulti-institutional registryPatient counselingLong-term outcomesA qualitative process evaluation of SBIRT implementation in pediatric trauma centers using the Science to Service Laboratory implementation strategy
Scott K, Mello M, Almonte G, Lemus E, Bromberg J, Baird J, Spirito A, Zonfrillo M, Lawson K, Lee L, Christison-Lagay E, Ruest S, Aidlen J, Kiragu A, Pruitt C, Nasr I, Maxson R, Ebel B, Becker S. A qualitative process evaluation of SBIRT implementation in pediatric trauma centers using the Science to Service Laboratory implementation strategy. Implementation Science Communications 2025, 6: 13. PMID: 39885597, PMCID: PMC11783764, DOI: 10.1186/s43058-025-00697-x.Peer-Reviewed Original ResearchQualitative process evaluationPediatric trauma centerReferral to treatmentSBIRT implementationTrauma centerBrief interventionProcess evaluationExit interviewsSite leadersConsolidated Framework for Implementation ResearchImplementation strategiesDidactic trainingAlcohol misuse screeningQualitative exit interviewsDirect care deliveryDirect care staffEvidence-based practicePediatric trauma careTrauma center staffAmerican College of SurgeonsPerformance feedbackStudy research teamSocial workersOrganizational level barriersDeliver SBIRT
2024
Local Infrastructure and Economy Predicts Traffic Related Fatalities in Children
Hellmann Z, Graetz E, Rehman S, Moore M, Schneider E, Christison-Lagay E, Solomon D. Local Infrastructure and Economy Predicts Traffic Related Fatalities in Children. Journal Of Pediatric Surgery 2024, 60: 162109. PMID: 39753412, DOI: 10.1016/j.jpedsurg.2024.162109.Peer-Reviewed Original ResearchMotor vehicle collisionsSocial Vulnerability IndexFatality Analysis Reporting SystemPoisson regressionRelated mortality rateMortality rateAverage annual mortality rateMultivariable Poisson regressionPoisson regression modelsTraffic fatalitiesArea deprivationWalking IndexUnivariate Poisson regressionAnnual mortality rateUS CensusDecile increaseMacroeconomic forcesPoor walkabilityState policy changesInclusion criteriaVehicle collisionsCrash-specific informationTraffic related fatalitiesRegression modelsWalkabilityUnnecessary Scans Lead to Unnecessary Re-scans: Evaluating Clinical Management of Low and Intermediate Risk Pediatric Traumatic Brain Injuries
Rivero R, Curran I, Hellmann Z, Carroll M, Hornick M, Solomon D, DiLuna M, Morrell P, Christison-Lagay E. Unnecessary Scans Lead to Unnecessary Re-scans: Evaluating Clinical Management of Low and Intermediate Risk Pediatric Traumatic Brain Injuries. Journal Of Pediatric Surgery 2024, 60: 162097. PMID: 39693726, DOI: 10.1016/j.jpedsurg.2024.162097.Peer-Reviewed Original ResearchPediatric Emergency Care Applied Research NetworkPECARN guidelinesPediatric Emergency Care Applied Research Network criteriaClinically important traumatic brain injuryComputed tomographyRisk patientsCross-sectional imagingIntermediate risk group patientsHead traumaIntracranial injuryIntermediate risk patientsRisk group patientsLow-risk injuriesLow-risk patientsRetrospective cohort studyClinically significant progressionEvaluate clinical managementIncreased hospital costsMild head traumaPenetrating head traumaLength of stayTraumatic brain injuryNon-accidental traumaBrain injuryRetrospective reviewMassive thymic hyperplasia in a toddler masquerading as a loculated pleural effusion: A case report
Zolfaghari E, Shaughnessy M, Wu H, Caty M, Christison-Lagay E, Hornick M. Massive thymic hyperplasia in a toddler masquerading as a loculated pleural effusion: A case report. Journal Of Pediatric Surgery Case Reports 2024, 110: 102885. DOI: 10.1016/j.epsc.2024.102885.Peer-Reviewed Original ResearchMassive thymic hyperplasiaChest X-rayThymic hyperplasiaCase reportComputed tomographyDifferential diagnosis of pediatric patientsSurveillance chest x-raysDiagnosis of pediatric patientsTrue thymic hyperplasiaRecurrent respiratory distressPost-operative coursePercutaneous core biopsyLoculated pleural effusionHistory of multiple admissionsPersistent respiratory symptomsSurgical resectionCore biopsyParapneumonic effusionPediatric patientsAbnormal findingsPleural effusionRight thoracotomyRare conditionRight hemithoraxSuspected pneumoniaSurgical Incisions in Pediatric Surgical Oncology
Christison-Lagay E. Surgical Incisions in Pediatric Surgical Oncology. 2024, 45-52. DOI: 10.1007/978-3-031-65890-7_9.Peer-Reviewed Original ResearchMinimally invasive approachResection of Wilms' tumorTreatment of pediatric cancersPediatric surgical oncologyLymph node resectionLymph node yieldSuperior mesenteric artery rootLymph node samplingLaparoscopic resectionThoracoabdominal approachNode resectionUnder-stagingNode yieldWilms tumorOncologic resectionSurgical approachSurgical treatmentArterial rootsInvasive approachSurgical incisionDistal aortaPoor outcomeResectionSurgical oncologyNode samplingEvaluation and Surgical Management of Pediatric Cutaneous Melanoma and Atypical Spitz and Non-Spitz Melanocytic Tumors (Melanocytomas): A Report From Children's Oncology Group
Sargen M, Barnhill R, Elder D, Swetter S, Prieto V, Ko J, Bahrami A, Gerami P, Karunamurthy A, Pappo A, Schuchter L, LeBoit P, Yeh I, Kirkwood J, Jen M, Dunkel I, Durham M, Christison-Lagay E, Austin M, Aldrink J, Mehrhoff C, Hawryluk E, Chu E, Busam K, Sondak V, Messina J, Puig S, Colebatch A, Coughlin C, Berrebi K, Laetsch T, Mitchell S, Seynnaeve B. Evaluation and Surgical Management of Pediatric Cutaneous Melanoma and Atypical Spitz and Non-Spitz Melanocytic Tumors (Melanocytomas): A Report From Children's Oncology Group. Journal Of Clinical Oncology 2024, 43: 1157-1167. PMID: 39365959, PMCID: PMC11908957, DOI: 10.1200/jco.24.01154.Peer-Reviewed Original ResearchSentinel lymph node biopsyAtypical Spitz tumorsCutaneous melanomaSpitz tumorsRe-excisionSurgical managementMelanocytic tumorsSurgical management of cutaneous melanomaManagement of cutaneous melanomaNational Comprehensive Cancer Network guidelinesLymph node biopsyDefinitive surgical treatmentProgression to CMChildren's Oncology GroupDiagnosis of CMNode biopsyExcisional biopsyOncology GroupMalignant potentialSurgical treatmentNetwork guidelinesBiopsyClinicopathological evaluationCohort studyMelanocytic neoplasmsFeasibility of a prospective pediatric melanocytic tumor clinical trial: A report of multidisciplinary clinician survey data from the Children's Oncology Group Rare Tumor Committee
Mitchell S, Christison‐Lagay E, Aldrink J, Sargen M, Laetsch T, Austin M, Jen M, Gartrell R, Karunamurthy A, Kirkwood J, Pappo A, Seynnaeve B. Feasibility of a prospective pediatric melanocytic tumor clinical trial: A report of multidisciplinary clinician survey data from the Children's Oncology Group Rare Tumor Committee. Pediatric Blood & Cancer 2024, 71: e31312. PMID: 39252525, PMCID: PMC11583290, DOI: 10.1002/pbc.31312.Peer-Reviewed Original ResearchAbstract B023: Multicenter histology image integration and multiscale deep learning for pediatric sarcoma subtype classification
Thiesen A, Domanskyi S, Foroughi pour A, Sheridan T, Neuhauser S, Stetson A, Dannheim K, Cameron D, Ahn S, Wu H, Christison-Lagay E, Bult C, Chuang J, Rubinstein J. Abstract B023: Multicenter histology image integration and multiscale deep learning for pediatric sarcoma subtype classification. Cancer Research 2024, 84: b023-b023. DOI: 10.1158/1538-7445.pediatric24-b023.Peer-Reviewed Original ResearchArtificial neural networkFeature extractionDeep learningTile sizeDeep learning feature extractionConvolutional artificial neural networksHistology datasetDeep learning backbonesTraining of artificial neural networksLearning feature extractionNon-overlapping tilesImage integrationImage format conversionFeature concatenationStain normalizationTiling parametersClassification performanceANN classifierClassification accuracyNeural networkAutomated classificationTraining modelDigitization of histology slidesFormat conversionDatasetSurgical management of rare tumors (Part 1)
Stetson A, Saluja S, Cameron D, Mansfield S, Polites S, Honeyman J, Dahl J, Austin M, Aldrink J, Christison‐Lagay E. Surgical management of rare tumors (Part 1). Pediatric Blood & Cancer 2024, 72: e31287. PMID: 39185712, DOI: 10.1002/pbc.31287.Peer-Reviewed Original ResearchOncology GroupManagement of rare tumorsEuropean Cooperative Study GroupDifferentiated thyroid cancerRare tumor typeRare pediatric cancerChildren's Oncology GroupCooperative Study GroupCooperative group effortsChildren aged 0Rare tumorAdult guidelinesSurgical managementThyroid cancerTumor typesRare cancersPediatric variantsTreatment strategiesStudy groupPediatric cancerCancer typesCancerTumorChildhood cancerAged 0Synoptic operative reports for pediatric surgical oncology
Baertschiger R, Polites S, Fusco J, Roach J, Christison‐Lagay E, Malek M, Gow K. Synoptic operative reports for pediatric surgical oncology. Pediatric Blood & Cancer 2024, 72: e31280. PMID: 39152638, DOI: 10.1002/pbc.31280.Peer-Reviewed Original ResearchImprove patient care outcomesElectronic medical record systemMultidisciplinary healthcare teamPatient care outcomesSurgical oncologySynoptic operative reportMedical record systemCare outcomesHealthcare teamPediatric surgical oncologyQuality assurance effortsDocumentation practicesData extractionDocumentation of surgical proceduresEffective communicationSynoptic reportingOperative notesRecording systemAssurance effortsEnhanced accessOncologyTumor characteristicsOperative reportsPediatric patientsResearch purposesEvaluation and Management of Biliary Dyskinesia in Children and Adolescents: A Systematic Review From the APSA Outcomes and Evidence-Based Committee
Kulaylat A, Lucas D, Chang H, Derderian S, Beres A, Ham P, Huerta C, Sulkowski J, Wakeman D, Englum B, Gulack B, Acker S, Gonzalez K, Levene T, Christison-Lagay E, Mansfield S, Yousef Y, Pennell C, Russell K, Rentea R, Tashiro J, Diesen D, Alemayehu H, Ricca R, Kelley-Quon L, Rialon K. Evaluation and Management of Biliary Dyskinesia in Children and Adolescents: A Systematic Review From the APSA Outcomes and Evidence-Based Committee. Journal Of Pediatric Surgery 2024, 59: 161678. PMID: 39227244, DOI: 10.1016/j.jpedsurg.2024.08.018.Peer-Reviewed Original ResearchSystematic reviewBiliary dyskinesiaOxford Levels of EvidencePreferred Reporting ItemsGrading of RecommendationsAmerican Pediatric Surgical Association OutcomesRisk of biasEvidence-based recommendationsDiagnostic criteriaPredictors of symptom reliefLevel of evidenceNon-operative managementResolution of symptomsPediatric-specific guidelinesOutcome of medical managementLong-term outcomesReporting ItemsNon-randomized studiesOxford LevelsMeta-analysesMethodological IndexAssociated outcomesClinical entityProspective studySymptom reliefCurrent surgical practice for central venous access to deliver chemotherapy and enteral access for nutritional support in pediatric patients with an oncological diagnosis
van den Bosch C, Grant C, Brown E, Morrison Z, Luques L, Christison‐Lagay E, Baertschiger R. Current surgical practice for central venous access to deliver chemotherapy and enteral access for nutritional support in pediatric patients with an oncological diagnosis. Pediatric Blood & Cancer 2024, 72: e31206. PMID: 39030929, DOI: 10.1002/pbc.31206.Peer-Reviewed Original ResearchCentral venous catheterCentral venous accessPediatric patientsEnteral accessVenous accessNutritional supportTunneled central venous cathetersParenteral nutrition deliveryAdministration of chemotherapyLong-term outcomesCurrent surgical practiceDeterminants of outcomeSurgical oncology patientsModern oncology practiceCentral venous catheter managementDeliver chemotherapyVenous cathetersNutrition deliveryNutritional assessmentAccess surgerySurgical perspectiveOncological diagnosisOncology patientsNutritional statusSurgical practiceImplementing Screening, Brief Interventions, and Referral to Treatment at Pediatric Trauma Centers: A Step Wedge Cluster Randomized Trial
Mello M, Baird J, Spirito A, Lee L, Kiragu A, Scott K, Zonfrillo M, Christison-Lagay E, Bromberg J, Ruest S, Pruitt C, Lawson K, Nasr I, Aidlen J, Maxson R, Becker S. Implementing Screening, Brief Interventions, and Referral to Treatment at Pediatric Trauma Centers: A Step Wedge Cluster Randomized Trial. Journal Of Pediatric Surgery 2024, 59: 161618. PMID: 39097494, PMCID: PMC11486576, DOI: 10.1016/j.jpedsurg.2024.07.003.Peer-Reviewed Original ResearchPediatric trauma centerElectronic health recordsReferral to treatmentBrief interventionTrauma centerImplementation strategiesPost-implementationAmerican College of Surgeons criteriaPrimary care providersCluster randomized trialStepped wedge cluster randomized trialCluster randomized designHigh-risk useTrauma patientsDeliver SBIRTLevel of Evidence Level IIAdolescent trauma patientsCare providersImplementation trialImplementing screeningAOD screeningHealth recordsSpecialty servicesPre-implementationEHR dataClassification and Surgical Management of Anorectal Malformations: A Systematic Review and Evidence-based Guideline From the APSA Outcomes and Evidence-based Practice Committee
Smith C, Rialon K, Kawaguchi A, Dellinger M, Goldin A, Acker S, Kulaylat A, Chang H, Russell K, Wakeman D, Derderian S, Englum B, Polites S, Lucas D, Ricca R, Levene T, Sulkowski J, Kelley-Quon L, Tashiro J, Christison-Lagay E, Mansfield S, Beres A, Huerta C, Ham P, Yousef Y, Rentea R, Committee T. Classification and Surgical Management of Anorectal Malformations: A Systematic Review and Evidence-based Guideline From the APSA Outcomes and Evidence-based Practice Committee. Journal Of Pediatric Surgery 2024, 59: 161598. PMID: 38997855, DOI: 10.1016/j.jpedsurg.2024.06.007.Peer-Reviewed Original ResearchSystematic reviewAnorectal malformationsEvidence-based best practicesSurgical managementConsensus-based questionsComprehensive search strategyPreferred Reporting ItemsComplex patient populationLevel of evidenceAmerican Pediatric Surgical Association OutcomesImprove careDiagnosis of anorectal malformationsGroup of anorectal malformationsTiming of surgical managementManagement of anorectal malformationsReporting ItemsLate repair groupMethod of fecal diversionTreatment of neonatesSurgical careOptimal surgical approachRate of prolapseMulti-institutional registryManagement of childrenSurgical management of anorectal malformationsScreening and Prophylaxis for Venous Thromboembolism in Pediatric Surgery: A Systematic Review
Kelley-Quon L, Acker S, St Peter S, Goldin A, Yousef Y, Ricca R, Mansfield S, Sulkowski J, Huerta C, Lucas D, Rialon K, Christison-Lagay E, Ham P, Rentea R, Beres A, Kulaylat A, Chang H, Polites S, Diesen D, Gonzalez K, Wakeman D, Baird R. Screening and Prophylaxis for Venous Thromboembolism in Pediatric Surgery: A Systematic Review. Journal Of Pediatric Surgery 2024, 59: 161585. PMID: 38964986, DOI: 10.1016/j.jpedsurg.2024.05.015.Peer-Reviewed Original ResearchIncidence of venous thromboembolismVenous thromboembolismPharmacological prophylaxisSystematic reviewUltrasound screeningEpidemiology of venous thromboembolismAmerican Pediatric Surgical Association OutcomesPreferred Reporting ItemsStudy systematically reviewsLow-molecular-weight heparinRoutine ultrasound screeningCongenital heart diseasePediatric trauma populationPediatric surgical populationBody mass indexPediatric surgical patientsMolecular weight heparinSequential compression devicesInjury Severity ScoreCentral line placementSpinal cord injuryInflammatory bowel diseaseWeb of Science databasesLength of stayReporting ItemsManagement and Outcomes of Pediatric Lymphatic Malformations: A Systematic Review From the APSA Outcomes and Evidence-Based Practice Committee
Huerta C, Beres A, Englum B, Gonzalez K, Levene T, Wakeman D, Yousef Y, Gulack B, Chang H, Christison-Lagay E, Ham P, Mansfield S, Kulaylat A, Lucas D, Rentea R, Pennell C, Sulkowski J, Russell K, Ricca R, Kelley-Quon L, Tashiro J, Rialon K, Committee T. Management and Outcomes of Pediatric Lymphatic Malformations: A Systematic Review From the APSA Outcomes and Evidence-Based Practice Committee. Journal Of Pediatric Surgery 2024, 59: 161589. PMID: 38914511, DOI: 10.1016/j.jpedsurg.2024.05.019.Peer-Reviewed Original ResearchSystematic reviewLymphatic malformationsConsensus statement of recommendationsPreferred Reporting ItemsEvidence-based recommendationsMedical therapyStatements of recommendationsLevel of Evidence 4Reporting ItemsModerate qualityPediatric lymphatic malformationsMulti-modality treatmentType of LMExtraction of dataConsensus statementOptimal individualized treatmentMacrocystic lesionsComplete responsePercutaneous treatmentMultidisciplinary approachSurgeryMalformationsOutcomesPatientsIndividualized treatmentA Unique Presentation of Nodular Masses in Infancy.
Velagala S, Heiden E, Lisse S, Wu H, Prior D, Chen G, Christison-Lagay E, Provini L, Antaya R, Spencer-Manzon M, Johnston L. A Unique Presentation of Nodular Masses in Infancy. NeoReviews 2024, 25: e370-e374. PMID: 38821908, DOI: 10.1542/neo.25-6-e370.Peer-Reviewed Original Research
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