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Karl Insogna, MD, FACP

Ensign Professor of Medicine (Endocrinology); Director, Yale Bone Center; Member, Medical Oncology; Attending Physician, Internal Medicine; Associate Director, Yale Center for X-Linked Hypophosphatemia, Endocrinology



Dr. Karl Insogna is a tenured Professor at Yale and an internationally recognized expert in the field of metabolic bone disease. He has published widely on the topic in the field's leading scientific journals, is quoted often in the lay press, and has frequently appeared on radio and television. He is a Fellow of the American Association for the Advancement of Science, and was a member of the National Institutes of Health Consensus Conference, which established new recommendations for the optimal level of calcium intake for all Americans - now adopted nationwide. He is a leading researcher in the causes of bone loss in such diseases as osteoporosis and primary hyperparathyroidism, and is currently conducting studies in, among other areas, the role of diet in the development of osteoporosis.

Education & Training

  • Chief Resident
    University of Rochester (1980)
  • Residency
    University of Rochester (1979)
  • MD
    University of Connecticut (1976)


  • Pediatric Grand Rounds: X-linked Hypophosphatemia: a Clinical Window into Phosphate Homeostasis with New Therapeutic Vistas
    San Francisco, United States 2019
  • Lankenau Grand Rounds: “What’s up with low phosphate?”
    Wynnewood, United States 2019
  • Wisconsin Endocrine Society: “Basic Bone Biology: Bewildering Babble from a Bombastic Bonehead or Really Relevant?”
    Brookfield, United States 2019
  • Endocrine Grand Rounds: “X-linked Hypophosphatemia: a clinical window into phosphate homeostasis with new therapeutic vistas”
    Milwaukee, United States 2019
  • FGF23
    Rio de Janeiro, Brazil 2019
  • X-linked Hypophosphatemia and Tumor-Induced Osteomalacia: Clinical Windows into Phosphate Homeostasis with New Therapeutic Vistas
    Kobe, Japan 2019
  • Skeletal Health Through the Lifespan
    Boston, United States 2019
  • What’s up with low phosphate? Diagnosing and treating hypophosphatemic disorders
    New York, United States 2019
  • "Osteoporosis for the Rheumatologist"
    Baltimore, United States 2018
  • Rare Bone Diseases
    New Orleans, United States 2018

Honors & Recognition

AwardAwarding OrganizationDate
Frederic C. Bartter AwardASBMR2021
Yale Medicine Distinguished Clinical Career AwardYale University School of Medicine2020
FellowAmerican College of Physicians2019
Champions of Hope, “RARE Champion of Hope –Medical Caregiver”The Global Genes Project2014

Professional Service

NIHOngoing2015 - Present
National Osteoporosis Foundation (NOF)Chair for the Audit Committee of the NOF2012 - Present
Raymond P. Wong Fellowship CommitteeThe Raymond P Wong Award honors the legacy of Raymond Wong, MD, who was one of the most dedicated primary care physicians in our community and a prominent contributor to the education of our students and house staff. Originally established by Yale New Haven Hospital, the Yale Medical Board and the New Haven County Medical Association in 2009, the Fellowship is now supported by Yale New Haven Hospital, the Yale Medical Board and the Department of Internal Medicine. The Wong Award is given to a graduating member or recent graduate of the Internal Medicine, Primary Care, or Medicine/Pediatric Residencies at Yale New Haven Hospital who accepts a practice position in an urban care setting in New Haven, preferably, but not exclusively, at the Cornell Scott Hill Health Center, for at least 3 years.2008 - Present
Women's Health Research at YaleMember of the Scientific Review Committee1997 - Present

Departments & Organizations