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The Yale School of Medicine was founded in 1810 at a time when a physician’s tools for treating illnesses were few. Today, with a full-time faculty of more than 2,000, including more than 500 research scientists, the school is one of the world’s leading institutions for biomedical research, education, and advanced clinical care.

Yale researchers have introduced countless medical and health advances over the last century, including the first success with antibiotics in the United States and the first use of chemotherapy to treat cancer. University scientists have been responsible for the identification of Lyme disease and the discovery of genes responsible for high blood pressure, osteoporosis, dyslexia, and Tourette's syndrome, among other disorders. Early work on the artificial heart and the creation of the first insulin pump took place at Yale, as did seminal discoveries about how the cell and its components function at the molecular level. Today, research activities take place in a wide range of departments, programs, and centers.

As of fiscal year 2013 Yale research has had 1,815 awards totaling $510.4 million, 416 U.S. and 704 worldwide active patents for Yale inventions, and 58 Yale-founded biotech companies.

The School of Medicine has extraordinary strength in the basic sciences and consistently ranks in the top handful of medical schools receiving funding from the National Institutes of Health.

There are currently hundreds of clinical research studies underway at Yale for a wide variety of conditions. There are also many trials that need healthy volunteers. Participants who are healthy are often needed to provide information that can be compared with people who have a specific illness or condition and to help establish the safety, dosage, and side effects of a new drug or treatment. All of these research studies are an important and necessary step in the process of making sure new treatments are safe and effective. They are also an opportunity for the volunteers who participate in them to try new experimental treatment options, help bring new medicine to patients who need it, and make a valuable contribution to the advancement of medical knowledge.