2013
Infectious particles, stress, and induced prion amyloids
Manuelidis L. Infectious particles, stress, and induced prion amyloids. Virulence 2013, 4: 373-383. PMID: 23633671, PMCID: PMC3714129, DOI: 10.4161/viru.24838.Peer-Reviewed Original ResearchMeSH KeywordsAmyloidAnimalsHumansImmunity, InnatePrion DiseasesPrionsProtein FoldingStress, PhysiologicalConceptsDiverse organismsInfectious TSE agentEnvironmental metagenomesTransmissible encephalopathiesHost prion proteinProtein misfoldingInfectious amyloidProtein modelingSusceptible PrP genotypesPrion amyloidInnate immune responsePrion proteinNeuronal agingDifferent amyloid proteinsTSE agentsMicrobial agentsNeurodegenerative diseasesPublic health measuresOrganismsBiological characteristicsNucleic acidsInfectious particlesAmyloid proteinProteinEndemic scrapie
2011
Replication and spread of CJD, kuru and scrapie agents in vivo and in cell culture
Miyazawa K, Emmerling K, Manuelidis L. Replication and spread of CJD, kuru and scrapie agents in vivo and in cell culture. Virulence 2011, 2: 188-199. PMID: 21527829, PMCID: PMC3149681, DOI: 10.4161/viru.2.3.15880.Peer-Reviewed Original ResearchConceptsGT1 cellsSporadic CJDTSE agentsScrapie agentAgent-specific patternsTransmissible spongiform encephalopathy agentsComplex innate immune responseSpongiform encephalopathy agentInnate immune responseHost prion proteinK scrapie agentHuman CJDCJD agentNeuropathological sequelaeBrain titersImmune responseHuman kuruClearance mechanismsCJDInhibitory effectEnvironmental agentsCell-based assaysKuruInfectious formDistinct incubation times