2018
Prokaryotic SPHINX 1.8 REP protein is tissue‐specific and expressed in human germline cells
Manuelidis L. Prokaryotic SPHINX 1.8 REP protein is tissue‐specific and expressed in human germline cells. Journal Of Cellular Biochemistry 2018, 120: 6198-6208. PMID: 30317668, DOI: 10.1002/jcb.27907.Peer-Reviewed Original ResearchConceptsOpen reading frameReplication initiation sequencesTissue-specific patternsHuman germline cellsSmall circular DNAREP peptidesGermline cellsMaternal inheritanceRep proteinSomatic cellsReading frameCell communicationEnvironmental infectious agentsMature spermDifferentiation functionPhage virusesCultured cellsCircular DNAInitiation sequenceSymbiotic elementsExocrine cellsFunctional differentiationSpinal cord synapsesMammalian brainDNA
2017
A prokaryotic viral sequence is expressed and conserved in mammalian brain
Yeh YH, Gunasekharan V, Manuelidis L. A prokaryotic viral sequence is expressed and conserved in mammalian brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 7118-7123. PMID: 28630311, PMCID: PMC5502646, DOI: 10.1073/pnas.1706110114.Peer-Reviewed Original ResearchConceptsTissue-specific differentiationViral sequencesMammalian evolutionLimited proteinase K digestionMammalian sequencesHost prion proteinMaternal inheritanceProkaryotic virusesNeuronal cell lineDNA sequencesEssential functionsImperfect homologyEnvironmental microorganismsProteinase K digestionPhage virusesPrion proteinAmyloid formCytoplasmic particlesNeural cellsK digestionMammalian brainCell linesSPX1MammalsHomology