2017
A prokaryotic viral sequence is expressed and conserved in mammalian brain
Yeh YH, Gunasekharan V, Manuelidis L. A prokaryotic viral sequence is expressed and conserved in mammalian brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 7118-7123. PMID: 28630311, PMCID: PMC5502646, DOI: 10.1073/pnas.1706110114.Peer-Reviewed Original ResearchConceptsTissue-specific differentiationViral sequencesMammalian evolutionLimited proteinase K digestionMammalian sequencesHost prion proteinMaternal inheritanceProkaryotic virusesNeuronal cell lineDNA sequencesEssential functionsImperfect homologyEnvironmental microorganismsProteinase K digestionPhage virusesPrion proteinAmyloid formCytoplasmic particlesNeural cellsK digestionMammalian brainCell linesSPX1MammalsHomology
2010
Nuclease resistant circular DNAs copurify with infectivity in scrapie and CJD
Manuelidis L. Nuclease resistant circular DNAs copurify with infectivity in scrapie and CJD. Journal Of NeuroVirology 2010, 17: 131-145. PMID: 21165784, DOI: 10.1007/s13365-010-0007-0.Peer-Reviewed Original ResearchMeSH KeywordsAcinetobacterAmino Acid SequenceAnimalsBase SequenceBrainConserved SequenceCreutzfeldt-Jakob SyndromeCricetinaeDeoxyribonucleasesDNA HelicasesDNA, CircularDNA, MitochondrialDNA-Directed DNA PolymeraseElectrophoresis, Agar GelGenome, BacterialHumansMiceMolecular Sequence DataNeuroblastomaNeurodegenerative DiseasesPlasmidsPolymerase Chain ReactionPrionsScrapieTumor Cells, Cultured