2013
Infectious particles, stress, and induced prion amyloids
Manuelidis L. Infectious particles, stress, and induced prion amyloids. Virulence 2013, 4: 373-383. PMID: 23633671, PMCID: PMC3714129, DOI: 10.4161/viru.24838.Peer-Reviewed Original ResearchConceptsDiverse organismsInfectious TSE agentEnvironmental metagenomesTransmissible encephalopathiesHost prion proteinProtein misfoldingInfectious amyloidProtein modelingSusceptible PrP genotypesPrion amyloidInnate immune responsePrion proteinNeuronal agingDifferent amyloid proteinsTSE agentsMicrobial agentsNeurodegenerative diseasesPublic health measuresOrganismsBiological characteristicsNucleic acidsInfectious particlesAmyloid proteinProteinEndemic scrapie
2011
High CJD infectivity remains after prion protein is destroyed
Miyazawa K, Emmerling K, Manuelidis L. High CJD infectivity remains after prion protein is destroyed. Journal Of Cellular Biochemistry 2011, 112: 3630-3637. PMID: 21793041, PMCID: PMC3202053, DOI: 10.1002/jcb.23286.Peer-Reviewed Original ResearchConceptsTransmissible spongiform encephalopathy agentsSpongiform encephalopathy agentInfectious particlesHost prion proteinPK digestionTotal PrPCJD infectivityInfectious homogenatesPrion proteinBrain resultsHigh titersTitersCell infectivityCell-based assaysCell culture assaysInfectivityProteinase K treatmentInfectious formPrPBrainCulture assaysAssaysProteinSensitive formK treatment
2001
The Stomach Divalent Ion-sensing Receptor SCAR Is a Modulator of Gastric Acid Secretion*
Geibel J, Wagner C, Caroppo R, Qureshi I, Gloeckner J, Manuelidis L, Kirchhoff P, Radebold K. The Stomach Divalent Ion-sensing Receptor SCAR Is a Modulator of Gastric Acid Secretion*. Journal Of Biological Chemistry 2001, 276: 39549-39552. PMID: 11507103, DOI: 10.1074/jbc.m107315200.Peer-Reviewed Original ResearchConceptsDivalent cation receptorsTransport proteinsPlasma membrane transport proteinsMembrane transport proteinsGastric acid secretionGastric parietal cellsParietal cellsExact functionNovel pathwayGastric glandsReceptor familySecretory cellsAcid secretionCalcium-sensing receptorBasolateral membranePathwayEndocrine pathwaysExtracellular cationsProteinNew insightsATPaseRat gastric glandsRegulationCellsDivalent cations