A prokaryotic viral sequence is expressed and conserved in mammalian brain
Yeh YH, Gunasekharan V, Manuelidis L. A prokaryotic viral sequence is expressed and conserved in mammalian brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 7118-7123. PMID: 28630311, PMCID: PMC5502646, DOI: 10.1073/pnas.1706110114.Peer-Reviewed Original ResearchConceptsTissue-specific differentiationViral sequencesMammalian evolutionLimited proteinase K digestionMammalian sequencesHost prion proteinMaternal inheritanceProkaryotic virusesNeuronal cell lineDNA sequencesEssential functionsImperfect homologyEnvironmental microorganismsProteinase K digestionPhage virusesPrion proteinAmyloid formCytoplasmic particlesNeural cellsK digestionMammalian brainCell linesSPX1MammalsHomology