New Mechanical Circulatory Support Devices

Synopsis of My Clinical Research

As principal or co-investigator in several clinical trials and studies, Dr. Mangi has focused his research efforts on his specialty interests, including the surgical treatment of ischemic heart failure, cellular therapy to treat advanced heart damage and expanded roles for left ventricular assist devices (LVADs). He is also interested in quality of care in LVAD patients, and desensitization of recipients awaiting cardiac transplantation. He is involved with three clinical trials investigating catheter-based therapies for valvular heart disease in high risk patients. He has previously led an additional eight clinical trials looking at outcomes of patients supported on newer generation LVADs. Dr. Mangi’s group investigates important questions regarding variables that influence clinical outcomes for therapies for advanced heart failure. Large national databases such as the Interagency Registry for Mechanical Assisted Circulatory Support (INTERMACS), United Network for Organ Sharing (UNOS), Society for Thoracic Surgeons (STS) and the Nationwide Inpatient Sample (NIS) have been used to analyze cost and cost-effectiveness for such therapies, clinical prediction modeling, diversity and health equity issues, quality of life and access to care.

Tutorial on LVADs available at Yale

LVAD is an acronym for Left Ventricular Assist Device.  The left ventricle is the major pumping chamber of the heart and sends blood to the rest of the organs in the body.  When the left ventricle fails, it can no longer provide the blood supply that the other organs in the body need.  This can result in a state of shock, and death.  In the simplest terms, an LVAD is a device which assists the failing left ventricle by diverting the blood-flow from the ventricle into a small pump, which then propels the blood into the aorta and to the rest of the organs. There are two types of pumps which currently exist. One kind resides within the body and gets its power supply by batteries which are external to the body.  Patients can go home with this type of pump.  The second type of pump actually resides outside the body.  This is used in critically sick patients and these patients have to stay in the intensive care unit.