2024
Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis
Hassab A, Hur D, Vallabhajosyula P, Tellides G, Assi R. Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis. JCI Insight 2024, 9: e172437. PMID: 38592807, PMCID: PMC11141924, DOI: 10.1172/jci.insight.172437.Peer-Reviewed Original ResearchConceptsDepartment of SurgerySmooth muscle cellsCellular response to injuryResponse to injuryImmunofluorescence confocal microscopyVessel wall repairPrimary lesionAscending aortaConduit functionAneurysmal diseaseDense fibrosisRadiological signsMural hematomaTear progressionMuscle cellsNon-hemorrhagicErythrocyte extravasationWall repairAortaTear completionInduce atherosclerosisHealed lesionsScattered leukocytesMinimal injuryConclusionThese findingsLiving in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis
Ram C, Yousef S, Ma W, Vallabhajosyula I, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Williams M, Geirsson A, Vallabhajosyula P. Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis. Scientific Reports 2024, 14: 4952. PMID: 38418864, PMCID: PMC10902341, DOI: 10.1038/s41598-024-52660-w.Peer-Reviewed Original ResearchConceptsAortic valve replacementSevere aortic stenosisAfrican American raceArea Deprivation IndexAortic stenosisSevere ASArea deprivation index rankAortic valve replacement ratesAmerican raceAortic valve interventionPresentation of sepsisDiagnosis of ASADI groupValve replacementValve interventionDeprived neighbourhoodsAV interventionDisadvantaged neighborhoodsPatientsFemale genderDeprivation indexHigh-ADI groupLow-ADI groupStenosisRace
2023
Aortic remodeling following hybrid arch repair with zone 0 to 5 thoracic endovascular aortic repairs for complex arch and descending thoracic aortic pathologies
Hameed I, Ahmed A, Pupovac S, Nassiri N, Assi R, Vallabhajosyula P. Aortic remodeling following hybrid arch repair with zone 0 to 5 thoracic endovascular aortic repairs for complex arch and descending thoracic aortic pathologies. JTCVS Open 2023, 17: 23-36. PMID: 38420535, PMCID: PMC10897673, DOI: 10.1016/j.xjon.2023.12.004.Peer-Reviewed Original ResearchHybrid aortic arch repairThoracic endovascular repairAortic arch repairAortic remodelingArch repairLuminal diameterZone 0Complete false lumen thrombosisLeft inferior pulmonary veinThoracic endovascular aortic repairComputed tomography angiography scansFalse lumen obliterationInferior left atriumFalse lumen thrombosisHigh-risk patientsHybrid arch repairAortic arch pathologiesCommon iliac arteryEndovascular aortic repairAdjunctive treatment strategyInferior pulmonary veinShort-term outcomesThoracic aortic pathologyTomography angiography scansAorta remodelingAortic Remodeling Following Hybrid Arch Repair for Complex Arch and Proximal Descending Thoracic Aortopathies
Hameed I, Ahmed A, Pupovac S, Komlo C, Amabile A, Nassiri N, Assi R, Vallabhajosyula P. Aortic Remodeling Following Hybrid Arch Repair for Complex Arch and Proximal Descending Thoracic Aortopathies. Journal Of Vascular Surgery 2023, 77: e255-e256. DOI: 10.1016/j.jvs.2023.03.361.Peer-Reviewed Original Research