2017
Effect of the Diabetic State on Islet Engraftment and Function in a Large Animal Model of Islet–Kidney Transplantation
Vallabhajosyula P, Hirakata A, Weiss M, Griesemer A, Shimizu A, Hong H, Habertheuer A, Tchipashvili V, Yamada K, Sachs DH. Effect of the Diabetic State on Islet Engraftment and Function in a Large Animal Model of Islet–Kidney Transplantation. Cell Transplantation 2017, 26: 1755-1762. PMID: 29338381, PMCID: PMC5784526, DOI: 10.1177/0963689717732993.Peer-Reviewed Original ResearchConceptsDiabetic stateIslet transplantationLarge animal modelEngraftment periodIslet engraftmentControl donorsIslet equivalentsAnimal modelsLong-term islet functionSimilar glucose tolerance testsDonor animalsChronic diabetic stateEnd-organ injuryAutologous islet transplantationGlucose tolerance testMiniature swine modelNephrectomized recipientsTotal pancreatectomyDiabetic nephropathyRecipient weightGlycemic controlOrgan injuryTolerance inductionDonor weightIschemic factors
2015
Monitoring of Allogeneic Islet Grafts in Nonhuman Primates Using MRI
Wang P, Schuetz C, Vallabhajosyula P, Medarova Z, Tena A, Wei L, Yamada K, Deng S, Markmann JF, Sachs DH, Moore A. Monitoring of Allogeneic Islet Grafts in Nonhuman Primates Using MRI. Transplantation 2015, 99: 1574-1581. PMID: 25806407, PMCID: PMC4551574, DOI: 10.1097/tp.0000000000000682.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsBiomarkersBlood GlucoseContrast MediaDextransDisease Models, AnimalGraft RejectionImmunosuppressive AgentsIslets of LangerhansIslets of Langerhans TransplantationMagnetic Resonance ImagingMagnetite NanoparticlesMaleOrgan SizePapio hamadryasPredictive Value of TestsStreptozocinTime FactorsTransplantation, HomologousConceptsGraft volumeIslet graftsBlood glucosePancreatic isletsNonhuman primatesAcute graft lossAllogeneic immune rejectionAllogeneic islet graftsWithdrawal of immunosuppressionPancreatic islet graftsVivo MRIGraft lossAllogeneic isletsGraft monitoringTreatment optionsIslet lossIslet transplantationRenal capsuleAllogeneic modelAutologous modelImmune rejectionMRISecondary damageImmunosuppressionIslets
2013
Assessing the Effect of Immunosuppression on Engraftment of Pancreatic Islets
Vallabhajosyula P, Hirakata A, Shimizu A, Okumi M, Tchipashvili V, Hong H, Yamada K, Sachs DH. Assessing the Effect of Immunosuppression on Engraftment of Pancreatic Islets. Transplantation 2013, 96: 372-378. PMID: 23883972, PMCID: PMC3786704, DOI: 10.1097/tp.0b013e31829f7515.Peer-Reviewed Original ResearchConceptsTriple-drug immunosuppressionIslet functionAllogeneic islet cell transplantationExperimental animalsLong-term islet functionTriple-drug immunosuppressive regimenIntravenous glucose tolerance testEquivalent glycemic controlEffect of immunosuppressionGlucose tolerance testNormal glucose regulationIslet cell transplantationVivo large animal modelLong-term functionIslet equivalents/Large animal modelImmunosuppressive regimenIslet doseImmunologic factorsRecipient weightEngrafted isletsGlycemic controlMinor histocompatibilityImmunosuppressive drugsCell transplantation
2011
Composite Islet-Kidneys From Single Baboon Donors Cure Diabetes Across Fully Allogenic Barriers
Yamada K, Hirakata A, Tchipashvili V, Shimizu A, Iwaki H, Griesemer A, Vallabhajosyula P, Moran S, Sachs DH. Composite Islet-Kidneys From Single Baboon Donors Cure Diabetes Across Fully Allogenic Barriers. American Journal Of Transplantation 2011, 11: 2603-2612. PMID: 21929644, PMCID: PMC3226882, DOI: 10.1111/j.1600-6143.2011.03733.x.Peer-Reviewed Original ResearchConceptsInsulin therapyFree isletsRenal capsuleEnd-stage diabetic nephropathyNonhuman primate modelPotential clinical applicabilityImmunosuppressive regimenAllogeneic barriersTotal pancreatectomyDiabetic nephropathyFBS levelsDiabetic hyperglycemiaPrimate modelPartial pancreatectomyDonor isletsMiniature swineNormal rangePotential cureGlucose regulationClinical applicabilityIsletsPancreatectomyTherapyIKsRecipients