2011
Composite Islet-Kidneys From Single Baboon Donors Cure Diabetes Across Fully Allogenic Barriers
Yamada K, Hirakata A, Tchipashvili V, Shimizu A, Iwaki H, Griesemer A, Vallabhajosyula P, Moran S, Sachs DH. Composite Islet-Kidneys From Single Baboon Donors Cure Diabetes Across Fully Allogenic Barriers. American Journal Of Transplantation 2011, 11: 2603-2612. PMID: 21929644, PMCID: PMC3226882, DOI: 10.1111/j.1600-6143.2011.03733.x.Peer-Reviewed Original ResearchConceptsInsulin therapyFree isletsRenal capsuleEnd-stage diabetic nephropathyNonhuman primate modelPotential clinical applicabilityImmunosuppressive regimenAllogeneic barriersTotal pancreatectomyDiabetic nephropathyFBS levelsDiabetic hyperglycemiaPrimate modelPartial pancreatectomyDonor isletsMiniature swineNormal rangePotential cureGlucose regulationClinical applicabilityIsletsPancreatectomyTherapyIKsRecipients
2009
In Vivo Imaging of Autologous Islet Grafts in the Liver and Under the Kidney Capsule in Non-Human Primates
Medarova Z, Vallabhajosyula P, Tena A, Evgenov N, Pantazopoulos P, Tchipashvili V, Weir G, Sachs D, Moore A. In Vivo Imaging of Autologous Islet Grafts in the Liver and Under the Kidney Capsule in Non-Human Primates. Transplantation 2009, 87: 1659-1666. PMID: 19502957, PMCID: PMC2746764, DOI: 10.1097/tp.0b013e3181a5cbc0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisContrast MediaDextransFerrosoferric OxideInsulinInsulin SecretionIronIslets of Langerhans TransplantationKidneyLiver TransplantationMagnetic Resonance ImagingMagnetite NanoparticlesOxidesPancreatectomyPapioSubrenal Capsule AssayTransplantation, AutologousTransplantation, HeterologousConceptsMagnetic resonance imagingSuperparamagnetic iron oxide contrast agentIslet graftsIron oxide contrast agentNon-human primatesRenal subcapsular islet graftsNon-human primate modelIslet graft survivalVivo magnetic resonance imagingIntrahepatic graftsGraft survivalPosttransplantation periodKidney capsuleIslet transplantationPrimate modelRenal capsulePartial pancreatectomyLiver parenchymaContrast agentsDay 1Drug AdministrationIslet labelingClinical situationsHuman isletsResonance imaging