2025
Direct perfusion for mesenteric ischaemia in acute type A aortic dissection: a glimpse into the mist of uncertainties
Ma W, Gao X, Ni B, Vallabhajosyula P. Direct perfusion for mesenteric ischaemia in acute type A aortic dissection: a glimpse into the mist of uncertainties. European Journal Of Cardio-Thoracic Surgery 2025, 67: ezaf044. PMID: 39951261, DOI: 10.1093/ejcts/ezaf044.Peer-Reviewed Original ResearchThe healthcare burden of isolated aortic valve insufficiency
Sultan I, Ryan M, Gunnarsson C, Heidrich N, Vallabhajosyula P. The healthcare burden of isolated aortic valve insufficiency. Scientific Reports 2025, 15: 4771. PMID: 39922868, PMCID: PMC11807181, DOI: 10.1038/s41598-025-87179-1.Peer-Reviewed Original ResearchConceptsHealthcare utilizationSAI patientsAnnual healthcare utilizationHealth care databasesYears post-diagnosisEstimate healthcare utilizationHome healthBaseline periodCare databaseMonths of continuous enrollmentCox proportional modelsPost-diagnosisAAI patientsMeasured outcomesHealthcareAI claimEstimate mortalityHealthcare burdenContinuous enrollmentExclusion criteriaUS patientsDiagnosis of aortic stenosisAortic valve insufficiencyProportional modelAnnual costEndovascular Repair vs Medical Therapy for Uncomplicated Acute Type B Dissection: Aortic Remodeling
Higaki A, Hameed I, Erez E, Hu K, Asmelash S, Chatterjee D, Shou B, Zafar M, Assi R, Vallabhajosyula P. Endovascular Repair vs Medical Therapy for Uncomplicated Acute Type B Dissection: Aortic Remodeling. Annals Of Thoracic Surgery Short Reports 2025 DOI: 10.1016/j.atssr.2025.01.012.Peer-Reviewed Original ResearchUncomplicated acute type B aortic dissectionThoracic endovascular aortic repairOptimal medical therapyMedical therapyAortic remodelingAortic levelsClinical outcomesClinical outcomes of thoracic endovascular aortic repairLumen diameterPatients treated with thoracic endovascular aortic repairOutcomes of thoracic endovascular aortic repairUncomplicated acute type B dissectionAcute type B aortic dissectionOMT patientsAcute type B dissectionType B aortic dissectionFavorable aortic remodelingOptimal initial managementInitial treatment modalityMedian follow-upType B dissectionEndovascular aortic repairB aortic dissectionFalse lumen thrombosisLeft subclavian arteryMidterm Outcomes of thoracic endovascular aortic repair versus Optimal Medical Therapy for Uncomplicated Acute Type B Dissection
Hu K, Ma W, Pupovac S, Hameed I, Fereydooni S, Li E, Larson H, Zafar M, Tonnessen B, Cardella J, Aboian E, Guzman R, Chaar C, Strosberg D, Williams M, Nassiri N, Assi R, Vallabhajosyula P. Midterm Outcomes of thoracic endovascular aortic repair versus Optimal Medical Therapy for Uncomplicated Acute Type B Dissection. JTCVS Open 2025 DOI: 10.1016/j.xjon.2024.12.013.Peer-Reviewed Original ResearchThoracic endovascular aortic repairThoracic endovascular aortic repair groupOptimal medical therapyOptimal medical therapy groupMidterm outcomes of thoracic endovascular aortic repairOutcomes of thoracic endovascular aortic repairUncomplicated acute type B aortic dissectionEndovascular aortic repairAcute kidney injuryAortic repairMidterm outcomesMedical therapyUncomplicated acute type B dissectionAcute type B aortic dissectionAcute type B dissectionAssociated with improved survivalType B aortic dissectionThirty-day ratesType B dissectionB aortic dissectionPost-operative dataMidterm follow-upIn-hospital/30-day mortalityKaplan-Meier survivalB dissectionSex-Differences in the Patterns of Cardiovascular Referral in Patients with Marfan, Ehlers-Danlos, and Loeys-Dietz Syndromes
Waldron C, Nasir A, Wang K, Chou A, Erez E, Vallabhajosyula P, Assi R. Sex-Differences in the Patterns of Cardiovascular Referral in Patients with Marfan, Ehlers-Danlos, and Loeys-Dietz Syndromes. JTCVS Open 2025 DOI: 10.1016/j.xjon.2025.01.002.Peer-Reviewed Original ResearchCardiothoracic surgeryConnective tissue diseaseFemale patientsEhlers-DanlosAortic pathologyLoeys-DietzCardiovascular medicineMale patientsTissue diseaseRetrospective review of patientsReview of patientsLoeys-Dietz syndromeDiagnosis of MFSReferral ratesSex differencesMFS patientsRetrospective reviewAortic diseaseRate of referralSurgeryPatientsMedical recordsClinical diagnosisElectronic medical recordsObjective diagnosis
2024
Successful Investigational Phage Therapy for Pan-Resistant Bacterial Mediastinitis Following Type II Hybrid Aortic Arch Replacement
Hameed I, Ahmed A, Gandhi S, Nassiri N, Steinbacher D, Vallabhajosyula P. Successful Investigational Phage Therapy for Pan-Resistant Bacterial Mediastinitis Following Type II Hybrid Aortic Arch Replacement. JACC Case Reports 2024, 29: 102816. PMID: 39691337, PMCID: PMC11646902, DOI: 10.1016/j.jaccas.2024.102816.Peer-Reviewed Original ResearchSternal wound infectionWound infectionPhage therapyStanford type B aortic dissectionThoracic endovascular aortic repairType B aortic dissectionMediastinal wound infectionsAortic arch surgeryAortic arch replacementDelayed sternal closureEndovascular aortic repairHybrid arch repairB aortic dissectionHybrid aortic arch replacementBacterial mediastinitisArch repairArch replacementArch surgeryAortic repairCardiac surgeryMediastinal drainsIntraoperative courseFlap reconstructionMorbid complicationSternal closureClinical Effectiveness of Genetic Testing Guidelines in Patients with Thoracic Aortic Aneurysms
Erez E, Acuna Higaki A, Cupo M, Phu T, Verma S, Assi R, Vallabhajosyula P. Clinical Effectiveness of Genetic Testing Guidelines in Patients with Thoracic Aortic Aneurysms. Journal Of Thoracic And Cardiovascular Surgery 2024 PMID: 39321868, DOI: 10.1016/j.jtcvs.2024.09.026.Peer-Reviewed Original ResearchFeatures of connective tissue diseaseThoracic aortic diseaseConnective tissue diseaseThoracic aortic aneurysmGenetic testing guidelinesSyndromic featuresMutation rateFamily historyVUS rateAortic aneurysmPrimary genesGenetic testingAssociated with thoracic aortic diseaseThoracic aorta diameterTesting guidelinesAorta diameterPathogen mutation rateAortic diseaseRisk stratificationSecondary genesPathogenic mutationsTissue diseaseClinical effectsVUSGenesRisk Scores (Risk Stratification)
Singh S, Vallabhajosyula P. Risk Scores (Risk Stratification). 2024, 50-55. DOI: 10.1201/9781003384779-6.Peer-Reviewed Original ResearchAge Is Just a Number: Complex Hybrid Arch Repair in a Nonagenarian
Hameed I, Ahmed A, Vallabhajosyula P. Age Is Just a Number: Complex Hybrid Arch Repair in a Nonagenarian. Canadian Journal Of Cardiology 2024, 40: 2246-2248. PMID: 39033813, DOI: 10.1016/j.cjca.2024.07.013.Peer-Reviewed Original ResearchThe role of hybrid arch repair with thoracic endovascular repair for contemporary management of complex arch and descending thoracoabdominal aortopathies
Ahmed A, Hameed I, Vallabhajosyula P. The role of hybrid arch repair with thoracic endovascular repair for contemporary management of complex arch and descending thoracoabdominal aortopathies. Journal Of Clinical Anesthesia And Intensive Care 2024, 4: 6-7. DOI: 10.46439/anesthesia.4.019.Peer-Reviewed Original ResearchThoracic endovascular aneurysm repair of a ruptured zone 0 mycotic thoracic aortic aneurysm
Kostiuk V, Vallabhajosyula P, Nassiri N, Tonnessen B. Thoracic endovascular aneurysm repair of a ruptured zone 0 mycotic thoracic aortic aneurysm. Annals Of Vascular Surgery - Brief Reports And Innovations 2024, 4: 100302. DOI: 10.1016/j.avsurg.2024.100302.Peer-Reviewed Original ResearchThoracic endovascular aneurysm repairEndovascular aneurysm repairAneurysm repairAcute type B aortic dissectionAcute onset chest painWeeks of antibiotic treatmentType B aortic dissectionAnti-impulse therapyExclusion of hemorrhageOnset chest painAortic arch debranchingPost-operative courseB aortic dissectionComputed tomography angiogramThoracic aortic aneurysmZone 0 TEVARArch debranchingMediastinal infectionChest painContrast extravasationBack painAntibiotic treatmentAortic aneurysmPost-operativelyFollow-upPeripheral Blood Extracellular Vesicle RNA Profiling: The Next Step in Cancer Liquid Biopsies
Hu R, Korutla L, Vallabhajosyula P. Peripheral Blood Extracellular Vesicle RNA Profiling: The Next Step in Cancer Liquid Biopsies. Annals Of Surgical Oncology 2024, 31: 4179-4181. PMID: 38755337, DOI: 10.1245/s10434-024-15400-y.Peer-Reviewed Original ResearchEfficacy and Safety of Botulinum Toxin Type A for the Prevention of Postoperative Atrial Fibrillation
Piccini J, Ahlsson A, Dorian P, Gillinov A, Kowey P, Mack M, Milano C, Noiseux N, Perrault L, Ryan W, Steinberg J, Voisine P, Waldron N, Gleason K, Titanji W, Leaback R, O’Sullivan A, Ferguson W, Benussi S, Investigators N, Akhter S, Andreas M, Benussi S, Castella M, Dalrymple-Hay M, El-Eshmawi A, Groh M, Hanke T, Jeanmart H, Katz M, McCullough J, Melby S, Miller J, Noiseux N, Romano M, Perrault L, Piccini J, Podgoreanu M, Ryan W, Sharma V, Shults C, Teman N, Voisine P, Whitson B, Wickbom A, Vallabhajosyula P, Yau T. Efficacy and Safety of Botulinum Toxin Type A for the Prevention of Postoperative Atrial Fibrillation. JACC Clinical Electrophysiology 2024, 10: 930-940. PMID: 38661602, DOI: 10.1016/j.jacep.2024.01.020.Peer-Reviewed Original ResearchPrevention of postoperative atrial fibrillationPostoperative atrial fibrillationCoronary artery bypass graftingRate of postoperative atrial fibrillationSafety of botulinum toxin type ACardiac surgeryPrimary endpointBotulinum toxin type AToxin type AAtrial fibrillationAssociated with increased morbidityRate of adverse eventsDose-ranging studyPlacebo-controlled trialOpen-chest cardiac surgeryType of surgeryEpicardial fat padsInjection of botulinum toxinArtery bypass graftingRandomized clinical trialsPlacebo-ControlledValve surgeryDouble-blindPlacebo groupContinuous AFIntimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis
Hassab A, Hur D, Vallabhajosyula P, Tellides G, Assi R. Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis. JCI Insight 2024, 9: e172437. PMID: 38592807, PMCID: PMC11141924, DOI: 10.1172/jci.insight.172437.Peer-Reviewed Original ResearchConceptsDepartment of SurgerySmooth muscle cellsCellular response to injuryResponse to injuryImmunofluorescence confocal microscopyVessel wall repairPrimary lesionAscending aortaConduit functionAneurysmal diseaseDense fibrosisRadiological signsMural hematomaTear progressionMuscle cellsNon-hemorrhagicErythrocyte extravasationWall repairAortaTear completionInduce atherosclerosisHealed lesionsScattered leukocytesMinimal injuryConclusionThese findingsLiving in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis
Ram C, Yousef S, Ma W, Vallabhajosyula I, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Williams M, Geirsson A, Vallabhajosyula P. Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis. Scientific Reports 2024, 14: 4952. PMID: 38418864, PMCID: PMC10902341, DOI: 10.1038/s41598-024-52660-w.Peer-Reviewed Original ResearchConceptsAortic valve replacementSevere aortic stenosisAfrican American raceArea Deprivation IndexAortic stenosisSevere ASArea deprivation index rankAortic valve replacement ratesAmerican raceAortic valve interventionPresentation of sepsisDiagnosis of ASADI groupValve replacementValve interventionDeprived neighbourhoodsAV interventionDisadvantaged neighborhoodsPatientsFemale genderDeprivation indexHigh-ADI groupLow-ADI groupStenosisRaceBicuspid Aortic Valve: Current Therapeutic Strategies
Usman Bin Mahmood S, Vallabhajosyula P, Milewski R. Bicuspid Aortic Valve: Current Therapeutic Strategies. Cardiology And Cardiovascular Medicine 2024, 1 DOI: 10.5772/intechopen.113315.Peer-Reviewed Original ResearchBicuspid aortic valveAortic valveTherapeutic strategiesValve-sparing root reimplantationBicuspid aortic valve patientsBAV syndromeSurgical therapeutic strategiesAortic valve replacementAortic valve patientsAortic valve stenosisAortic valve repairLong-term outcomesCurrent therapeutic strategiesBAV populationAorta replacementBentall procedureValve patientsValve replacementValve stenosisRoot reimplantationValve repairValvular pathologySurgical proceduresGeneral populationIndividualized approachContributors to Volume 2
Abouljoud M, Abu-Gazala S, Akbulut S, Al Harakeh H, Aleassa E, Alqahtani S, Ascher N, Asolati M, Aucejo F, Bababekov Y, Baker T, Barth R, Bayer J, Benedetti E, Benedetti C, Bhati C, Bizzaro D, Bond G, Braun H, Broelsch C, Broering D, Bromberg J, Brown R, Brucker S, Bui J, Burra P, Cagliani J, Carr-Boyd P, Cascalho M, Cattral M, Chan S, Chen C, Cherqui D, Ciria R, Crane A, Cravedi P, Kwon C, de Magnee C, Delmonico F, De Prisco G, Di Bella C, Di Cocco P, di Sabato D, Diaz G, Dudkowski M, Eagle E, Eisenson D, Emond J, Emre S, Ericzon B, Florman S, Freise C, Fronek J, Fung J, Furian L, Ganoza A, Genedy L, Giacomo G, Giglio M, Gorrell D, Gruessner R, Gruessner A, Hashimoto K, Heffron N, Heffron T, Heimbach J, Hester J, Hibi T, Hirao H, Humar A, Hwang S, Iesari S, Ince V, Isik B, Issa F, Jacobs C, Järvholm S, Jeon H, Johannesson L, Kalis A, Kaplan A, Khan K, Khanna A, Kim K, Kim W, Kittle H, Knechtle S, Koppe S, Kord A, Kristek J, Kumar S, Kupiec-Weglinski J, Lake J, LaMattina J, Lee S, Lerut J, Lin T, Bianco E, Lo C, Malago M, Malik S, Maluf D, Marique L, Martin D, Mazariegos G, Mazariegos G, McCallion O, McGraw L, Meier R, Merola J, Miller C, Moon D, Moore H, Muller Y, Nadalin S, Nada A, Nakamura K, Ogle B, Ogura Y, Olausson M, Olthoff K, Ong A, Paci P, Piedrahita J, Pinna A, Pirotte T, Pita A, Platt J, Pomfret E, Pomposelli J, Quintini C, Reding R, Renz J, Rizzari M, Roberts J, Roggen F, Roll G, Sachs D, Salerno D, Samstein B, Schmitz R, Selzner N, Senzolo M, Sonmez T, Stock P, Tabrizian P, Tambucci R, Tanaka K, Testa G, Thaker S, Thomson M, Tranäng M, Troisi R, Tulla K, Tully M, Tumeh J, Tzvetanov I, Umman V, Unver U, Vallabhajosyula P, Wahid N, Wilczek H, Williams N, Xie J, Yamada K, Yilmaz S, Zanetto A, Zaza G, Zeytunlu M. Contributors to Volume 2. 2024, xiii-xviii. DOI: 10.1016/b978-0-443-23571-9.01004-5.Peer-Reviewed Original Research
2023
Aortic remodeling following hybrid arch repair with zone 0 to 5 thoracic endovascular aortic repairs for complex arch and descending thoracic aortic pathologies
Hameed I, Ahmed A, Pupovac S, Nassiri N, Assi R, Vallabhajosyula P. Aortic remodeling following hybrid arch repair with zone 0 to 5 thoracic endovascular aortic repairs for complex arch and descending thoracic aortic pathologies. JTCVS Open 2023, 17: 23-36. PMID: 38420535, PMCID: PMC10897673, DOI: 10.1016/j.xjon.2023.12.004.Peer-Reviewed Original ResearchHybrid aortic arch repairThoracic endovascular repairAortic arch repairAortic remodelingArch repairLuminal diameterZone 0Complete false lumen thrombosisLeft inferior pulmonary veinThoracic endovascular aortic repairComputed tomography angiography scansFalse lumen obliterationInferior left atriumFalse lumen thrombosisHigh-risk patientsHybrid arch repairAortic arch pathologiesCommon iliac arteryEndovascular aortic repairAdjunctive treatment strategyInferior pulmonary veinShort-term outcomesThoracic aortic pathologyTomography angiography scansAorta remodelingCirculating T cell specific extracellular vesicle profiles in cardiac allograft acute cellular rejection
Korutla L, Hoffman J, Rostami S, Hu R, Korutla V, Markmann C, Mullan C, Sotolongo A, Habertheuer A, Romano C, Acker M, Sen S, Agarwal D, Jayaraman A, Li B, Davis M, Naji A, Vallabhajosyula P. Circulating T cell specific extracellular vesicle profiles in cardiac allograft acute cellular rejection. American Journal Of Transplantation 2023, 24: 419-435. PMID: 38295008, DOI: 10.1016/j.ajt.2023.10.021.Peer-Reviewed Original ResearchAcute cellular rejectionAllogeneic transplant recipientsTransplant recipientsCellular rejectionHeart transplantationAlloreactive T cell activationEarly acute cellular rejectionT-cell receptor sequencingSyngeneic transplant recipientsCell receptor sequencingClinical heart transplantationT cell clonesNovel candidate biomarkersT cell activationQuantitative RT-PCRRecipient circulationOrgan transplantationT cellsVesicle profilesNoninvasive biomarkersCandidate biomarkersCell activationRegulatory markersDonor cardiomyocytesTransplantationOne-Year Results of a Low-Profile Endograft in Acute, Complicated Type B Aortic Dissection
Rossi P, Desai N, Malaisrie S, Lyden S, Nassiri N, Reece T, Adams J, Moanie S, Shults C, Investigators R, Vallabhajosyula P, Panneton J, Kumins N, Sharafuddin M, Toursavadkohi S, Ullery B, Duwayri Y, Han S, Rahimi S, Meisner R, Dryjski M, Starnes B, Fukuhara S, Cheema M. One-Year Results of a Low-Profile Endograft in Acute, Complicated Type B Aortic Dissection. The Annals Of Thoracic Surgery 2023, 117: 336-343. PMID: 37769702, DOI: 10.1016/j.athoracsur.2023.08.035.Peer-Reviewed Original ResearchConceptsType B aortic dissectionComplicated type B aortic dissectionMajor adverse eventsB aortic dissectionAdverse eventsCause mortalityAortic dissectionTechnical successEnd pointAortic diameter growthFalse lumen perfusionPrimary end pointSecondary end pointsKaplan-Meier analysisOne-year resultsParaplegia/paraparesisLong-term outcomesUnited States CentersMedian hospitalizationAortic expansionPatency lossRenal failurePivotal trialsRetrograde dissectionIliac artery
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