2025
Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations
Hemalatha A, Li Z, Gonzalez D, Matte-Martone C, Tai K, Lathrop E, Gil D, Ganesan S, Gonzalez L, Skala M, Perry R, Greco V. Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations. Nature Cell Biology 2025, 27: 218-231. PMID: 39762578, PMCID: PMC11821535, DOI: 10.1038/s41556-024-01574-w.Peer-Reviewed Original ResearchConceptsWild-type cellsOxidative tricarboxylic acid cycleOncogenic mutationsTricarboxylic acid cycleSingle-cell resolutionMutant phenotypeMutant cellsMutant epidermisCell competitionMetabolic rewiringAcid cycleCellular redoxStem cellsMutant modelsSkin epithelial stem cellsEpidermal stem cellsContribution of glucoseEpithelial stem cellsCytosolic redoxRedox ratioMetabolic stateMutationsHrasG12VSkin epidermisCells
2023
Injury prevents Ras mutant cell expansion in mosaic skin
Gallini S, Annusver K, Rahman N, Gonzalez D, Yun S, Matte-Martone C, Xin T, Lathrop E, Suozzi K, Kasper M, Greco V. Injury prevents Ras mutant cell expansion in mosaic skin. Nature 2023, 619: 167-175. PMID: 37344586, PMCID: PMC10322723, DOI: 10.1038/s41586-023-06198-y.Peer-Reviewed Original ResearchConceptsWild-type cellsRas family proteinsCell cycle inhibitor p21Family proteinsOncogenic RasGenetic approachesMosaic tissuesInhibition of EGFRInhibitor p21EGFR ligandsEGFR pathwayCell expansionAberrant growthConstitutive lossDifferential activationParacrine secretionAbsence of injuryCellsCompetitive balanceInjury repairHealthy skinInjurySkinProteinPathway
2019
Flexibility sustains epithelial tissue homeostasis
Tai K, Cockburn K, Greco V. Flexibility sustains epithelial tissue homeostasis. Current Opinion In Cell Biology 2019, 60: 84-91. PMID: 31153058, PMCID: PMC6756930, DOI: 10.1016/j.ceb.2019.04.009.Peer-Reviewed Original ResearchConceptsEpithelial homeostasisEpithelial tissue homeostasisLive-imaging techniquesEpithelial cell interactionsIndividual epithelial cellsOrganism's lifetimeTissue homeostasisCell plasticityCell biologyMolecular mechanismsPathological settingsCell interactionsHomeostasisEpithelial cellsRecent advancesGeneticsBiologyMutationsImportant implicationsEpitheliumMechanismPlasticityCells
2017
Correction of aberrant growth preserves tissue homeostasis
Brown S, Pineda CM, Xin T, Boucher J, Suozzi KC, Park S, Matte-Martone C, Gonzalez DG, Rytlewski J, Beronja S, Greco V. Correction of aberrant growth preserves tissue homeostasis. Nature 2017, 548: 334-337. PMID: 28783732, PMCID: PMC5675114, DOI: 10.1038/nature23304.Peer-Reviewed Original Research
2014
β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche
Deschene ER, Myung P, Rompolas P, Zito G, Sun TY, Taketo MM, Saotome I, Greco V. β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche. Science 2014, 343: 1353-1356. PMID: 24653033, PMCID: PMC4096864, DOI: 10.1126/science.1248373.Peer-Reviewed Original ResearchConceptsWild-type cellsWnt/β-catenin signalingΒ-catenin signalingΒ-catenin activationMouse hair follicle stem cellsΒ-cateninStem cell nicheHair follicle stem cellsFollicle stem cellsNiche signalsMutant cellsCell divisionCell nicheCoordinated regenerationHair growthWnt ligandsCellular displacementCell behaviorStem cellsHair regenerationTissue growthSignalingCellsTissue regenerationActivation
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