2017
Correction of aberrant growth preserves tissue homeostasis
Brown S, Pineda CM, Xin T, Boucher J, Suozzi KC, Park S, Matte-Martone C, Gonzalez DG, Rytlewski J, Beronja S, Greco V. Correction of aberrant growth preserves tissue homeostasis. Nature 2017, 548: 334-337. PMID: 28783732, PMCID: PMC5675114, DOI: 10.1038/nature23304.Peer-Reviewed Original Research
2014
β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche
Deschene ER, Myung P, Rompolas P, Zito G, Sun TY, Taketo MM, Saotome I, Greco V. β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche. Science 2014, 343: 1353-1356. PMID: 24653033, PMCID: PMC4096864, DOI: 10.1126/science.1248373.Peer-Reviewed Original ResearchConceptsWild-type cellsWnt/β-catenin signalingΒ-catenin signalingΒ-catenin activationMouse hair follicle stem cellsΒ-cateninStem cell nicheHair follicle stem cellsFollicle stem cellsNiche signalsMutant cellsCell divisionCell nicheCoordinated regenerationHair growthWnt ligandsCellular displacementCell behaviorStem cellsHair regenerationTissue growthSignalingCellsTissue regenerationActivation
2009
A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration
Greco V, Chen T, Rendl M, Schober M, Pasolli HA, Stokes N, dela Cruz-Racelis J, Fuchs E. A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration. Cell Stem Cell 2009, 4: 155-169. PMID: 19200804, PMCID: PMC2668200, DOI: 10.1016/j.stem.2008.12.009.Peer-Reviewed Original ResearchConceptsBMP inhibitorsHair germHG cellsStem cellsStem cell activationHair regenerationTransit-amplifying cellsBulge stem cellsDermal papillaCyclic boutsTranscriptional profilingElevated FGFPrecocious activityHair folliclesBulge cellsLate telogenWntCell clustersCell activationCellsTwo-step mechanismSmall cell clustersInitial stepRegenerationInhibitors