2023
Injury prevents Ras mutant cell expansion in mosaic skin
Gallini S, Annusver K, Rahman N, Gonzalez D, Yun S, Matte-Martone C, Xin T, Lathrop E, Suozzi K, Kasper M, Greco V. Injury prevents Ras mutant cell expansion in mosaic skin. Nature 2023, 619: 167-175. PMID: 37344586, PMCID: PMC10322723, DOI: 10.1038/s41586-023-06198-y.Peer-Reviewed Original ResearchConceptsWild-type cellsRas family proteinsCell cycle inhibitor p21Family proteinsOncogenic RasGenetic approachesMosaic tissuesInhibition of EGFRInhibitor p21EGFR ligandsEGFR pathwayCell expansionAberrant growthConstitutive lossDifferential activationParacrine secretionAbsence of injuryCellsCompetitive balanceInjury repairHealthy skinInjurySkinProteinPathway
2014
β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche
Deschene ER, Myung P, Rompolas P, Zito G, Sun TY, Taketo MM, Saotome I, Greco V. β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche. Science 2014, 343: 1353-1356. PMID: 24653033, PMCID: PMC4096864, DOI: 10.1126/science.1248373.Peer-Reviewed Original ResearchConceptsWild-type cellsWnt/β-catenin signalingΒ-catenin signalingΒ-catenin activationMouse hair follicle stem cellsΒ-cateninStem cell nicheHair follicle stem cellsFollicle stem cellsNiche signalsMutant cellsCell divisionCell nicheCoordinated regenerationHair growthWnt ligandsCellular displacementCell behaviorStem cellsHair regenerationTissue growthSignalingCellsTissue regenerationActivation