2025
Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations
Hemalatha A, Li Z, Gonzalez D, Matte-Martone C, Tai K, Lathrop E, Gil D, Ganesan S, Gonzalez L, Skala M, Perry R, Greco V. Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations. Nature Cell Biology 2025, 27: 218-231. PMID: 39762578, PMCID: PMC11821535, DOI: 10.1038/s41556-024-01574-w.Peer-Reviewed Original ResearchConceptsWild-type cellsOxidative tricarboxylic acid cycleOncogenic mutationsTricarboxylic acid cycleSingle-cell resolutionMutant phenotypeMutant cellsMutant epidermisCell competitionMetabolic rewiringAcid cycleCellular redoxStem cellsMutant modelsSkin epithelial stem cellsEpidermal stem cellsContribution of glucoseEpithelial stem cellsCytosolic redoxRedox ratioMetabolic stateMutationsHrasG12VSkin epidermisCells
2024
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation
Xin T, Gallini S, Wei H, Gonzalez D, Matte-Martone C, Machida H, Fujiwara H, Pasolli H, Suozzi K, Gonzalez L, Regot S, Greco V. Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation. Nature Cell Biology 2024, 26: 859-867. PMID: 38689013, PMCID: PMC11519783, DOI: 10.1038/s41556-024-01413-y.Peer-Reviewed Original ResearchERK signalingStem cellsSquamous cell carcinomaHair folliclesOncogenic KRAS mutationsCell carcinomaKRAS mutationsSustained ERK activationERK signaling dynamicsOncogenic mutationsOncogenic KRASERK activationStem cell behaviorIntravital imagingAbnormal cell divisionModulates specific featuresKrasG12DTissue deformationSpatiotemporally specific mannerSustained ERK signalingMutationsLiving miceFolliclesTissue disruptionSingle-cell level
2019
Hair follicle regeneration suppresses Ras-driven oncogenic growth
Pineda CM, Gonzalez DG, Matte-Martone C, Boucher J, Lathrop E, Gallini S, Fons NR, Xin T, Tai K, Marsh E, Nguyen DX, Suozzi KC, Beronja S, Greco V. Hair follicle regeneration suppresses Ras-driven oncogenic growth. Journal Of Cell Biology 2019, 218: 3212-3222. PMID: 31488583, PMCID: PMC6781447, DOI: 10.1083/jcb.201907178.Peer-Reviewed Original ResearchConceptsHair folliclesHras mutationsOncogenic growthHair follicle stem cellsSkin hair folliclesTumor developmentFollicle stem cellsHair follicle regenerationSkin epitheliumSecondary mutationsBenign outgrowthFolliclesStem cellsTissueCertain tissuesFollicle regenerationCellsContinuous tissueWild-type neighborsDistinct mechanismsDifferent outcomesMutationsEnhanced capacityInjuryFlexibility sustains epithelial tissue homeostasis
Tai K, Cockburn K, Greco V. Flexibility sustains epithelial tissue homeostasis. Current Opinion In Cell Biology 2019, 60: 84-91. PMID: 31153058, PMCID: PMC6756930, DOI: 10.1016/j.ceb.2019.04.009.Peer-Reviewed Original ResearchConceptsEpithelial homeostasisEpithelial tissue homeostasisLive-imaging techniquesEpithelial cell interactionsIndividual epithelial cellsOrganism's lifetimeTissue homeostasisCell plasticityCell biologyMolecular mechanismsPathological settingsCell interactionsHomeostasisEpithelial cellsRecent advancesGeneticsBiologyMutationsImportant implicationsEpitheliumMechanismPlasticityCells
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