2017
Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease
Taguchi YV, Liu J, Ruan J, Pacheco J, Zhang X, Abbasi J, Keutzer J, Mistry PK, Chandra SS. Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease. Journal Of Neuroscience 2017, 37: 9617-9631. PMID: 28847804, PMCID: PMC5628407, DOI: 10.1523/jneurosci.1525-17.2017.Peer-Reviewed Original ResearchConceptsΑ-synuclein pathologyParkinson's diseaseCommon genetic risk factorGenetic risk factorsGaucher diseaseRisk factorsPD pathologyOligomeric α-synuclein speciesPD mouse brainPathological aggregationΑ-synuclein speciesHuman cellsAttractive therapeutic targetΑ-synuclein aggregationPrevalent neurodegenerative disorderGD patientsFunction mechanismPD riskMouse linesMutantsTherapeutic targetMutationsMouse brainNeurodegenerative disordersDisease
2014
Synucleins☆
Vargas K, Chandra S. Synucleins☆. 2014 DOI: 10.1016/b978-0-12-801238-3.04785-1.Peer-Reviewed Original ResearchVertebrate-specific gene familyHuman α-synuclein geneSynaptic vesicle cyclingGene familyNormal physiological functionFamilial Parkinson's diseaseVesicle cyclingΑ-synucleinKDa proteinPhysiological functionsΒ-synucleinΑ-synuclein geneNeurodegenerative disordersProteinΓ-synucleinPresynaptic terminalsSynuclein
2009
Synucleins
Chandra S. Synucleins. 2009, 833-837. DOI: 10.1016/b978-008045046-9.01354-1.Peer-Reviewed Original Research