2009
Murine B Cell Response to TLR7 Ligands Depends on an IFN-β Feedback Loop
Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A. Murine B Cell Response to TLR7 Ligands Depends on an IFN-β Feedback Loop. The Journal Of Immunology 2009, 183: 1569-1576. PMID: 19587008, PMCID: PMC2929820, DOI: 10.4049/jimmunol.0803899.Peer-Reviewed Original Research
2006
Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus
Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ. Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus. Immunity 2006, 25: 417-428. PMID: 16973389, DOI: 10.1016/j.immuni.2006.07.013.Peer-Reviewed Original ResearchConceptsLupus-prone miceSystemic lupus erythematosusAutoimmune diseasesToll-like receptor 7Toll-like receptor 9Absence of TLR9TLR7-deficient miceDevelopment of lupusPlasmacytoid DCsLupus erythematosusSerum IgGSusceptible miceAutoantibody specificitiesReceptor 7Receptor 9DNA autoantibodiesClinical diseaseIFN-alphaMurine modelLymphocyte activationTLR7TLR9Regulatory roleDiseaseMice